Featured Research

from universities, journals, and other organizations

Increased mortality in HIV-positive South African men versus women is unrelated to HIV/AIDS

Date:
September 4, 2012
Source:
Public Library of Science
Summary:
In South Africa, HIV-infected men who are receiving treatment with anti-HIV drugs (antiretroviral therapy) are almost a third more likely to die than HIV-positive women who are receiving similar treatment: however, these differences are likely to be due to gender differences in death rates in the general population rather than related to HIV, according to a study by a team of international researchers.

In South Africa, HIV-infected men who are receiving treatment with anti-HIV drugs (antiretroviral therapy) are almost a third more likely to die than HIV-positive women who are receiving similar treatment: however, these differences are likely to be due to gender differences in death rates in the general population rather than related to HIV, according to a study by a team of international researchers published in this week's PLOS Medicine.

Related Articles


An international research collaboration, led by Morna Cornell from the University of Cape Town, analyzed data collected from 46,201 adults who started taking antiretroviral therapy between 2002 and 2009 in eight HIV treatment programs in South Africa.

They found that at the start of treatment, men generally had a lower CD4 count (a biomarker of HIV activity -- a lower count indicates increased infection) and were more likely to have advanced HIV disease than women. But even after allowing for these factors, the researchers found that HIV-positive men on antiretroviral therapy were almost a third (31%) more likely to die than HIV-positive women on similar treatment.

The researchers also found that men were more likely to be lost to follow up than women, but men and women who were lost to follow-up were equally likely to die. Furthermore, women had a slightly better immunological response to antiretroviral therapy than men but suppression of the HIV virus was similar in both genders.

However, importantly, the researchers found that, the gender differences in the deaths rates they observed in this study were smaller than the gender differences in death rates (standardized by age) in the general (HIV-negative) South African population -- a situation that may explain their results

The researchers say: "HIV-infected men have higher mortality on antiretroviral therapy than women in South African programmes, but these differences are only partly explained by more advanced HIV disease at the time of antiretroviral therapy initiation, differential loss-to-follow-up and subsequent mortality, and differences in responses to treatment."

They conclude: "The observed differences in mortality on antiretroviral therapy may be best explained by background differences in mortality between men and women in the South African population unrelated to the HIV/AIDS epidemic."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Morna Cornell, Michael Schomaker, Daniela Belen Garone, Janet Giddy, Christopher J. Hoffmann, Richard Lessells, Mhairi Maskew, Hans Prozesky, Robin Wood, Leigh F. Johnson, Matthias Egger, Andrew Boulle, Landon Myer. Gender Differences in Survival among Adult Patients Starting Antiretroviral Therapy in South Africa: A Multicentre Cohort Study. PLoS Medicine, 2012; 9 (9): e1001304 DOI: 10.1371/journal.pmed.1001304

Cite This Page:

Public Library of Science. "Increased mortality in HIV-positive South African men versus women is unrelated to HIV/AIDS." ScienceDaily. ScienceDaily, 4 September 2012. <www.sciencedaily.com/releases/2012/09/120904170920.htm>.
Public Library of Science. (2012, September 4). Increased mortality in HIV-positive South African men versus women is unrelated to HIV/AIDS. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2012/09/120904170920.htm
Public Library of Science. "Increased mortality in HIV-positive South African men versus women is unrelated to HIV/AIDS." ScienceDaily. www.sciencedaily.com/releases/2012/09/120904170920.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins