Featured Research

from universities, journals, and other organizations

Cells surf through a microfluidic chip on fluid streamlines created by an oscillating plate

Date:
September 12, 2012
Source:
American Institute of Physics (AIP)
Summary:
Scientists who study tissue engineering and test new drugs often need to sort, rotate, move, and otherwise manipulate individual cells. They can do this by prodding the cells into place with a mechanical probe or coaxing them in the desired direction with acoustic waves, electric fields, or flowing fluids. Techniques that rely on direct physical contact can position individual cells with a high level of precision while non-contact techniques are often faster for sorting large numbers of cells. An international team of researchers has now developed a way to manipulate cells that combines some of the benefits of both contact and non-contact methods.

Scientists who study tissue engineering and test new drugs often need to sort, rotate, move, and otherwise manipulate individual cells. They can do this by prodding the cells into place with a mechanical probe or coaxing them in the desired direction with acoustic waves, electric fields, or flowing fluids. Techniques that rely on direct physical contact can position individual cells with a high level of precision while non-contact techniques are often faster for sorting large numbers of cells.

Related Articles


An international team of researchers has now developed a way to manipulate cells that combines some of the benefits of both contact and non-contact methods.

The researchers suspended a tiny plate in a microfluidic channel and used magnetic controls to move the plate up and down and back and forth. The movements generated fluid flow patterns that varied depending on characteristics of the oscillations such as frequency, magnitude, and phase, and the relative position of the plate and the channel wall. Changing these parameters allowed the researchers to create different streamlines that either pulled or pushed a cell toward or away from the plate, as well as vortices that rotated the cell. When the cell reached the plate the researchers could also use the plate for precise, direct-contact manipulations.

The researchers demonstrated the technique, which they describe in a paper published in the American Institute of Physics' journal Applied Physics Letters, by manipulating a single bovine egg cell. As a next step, the team plans to demonstrate control of multiple cells simultaneously.


Story Source:

The above story is based on materials provided by American Institute of Physics (AIP). Note: Materials may be edited for content and length.


Journal Reference:

  1. Masaya Hagiwara, Tomohiro Kawahara, Fumihito Arai. Local streamline generation by mechanical oscillation in a microfluidic chip for noncontact cell manipulations. Applied Physics Letters, 2012; 101 (7): 074102 DOI: 10.1063/1.4746247

Cite This Page:

American Institute of Physics (AIP). "Cells surf through a microfluidic chip on fluid streamlines created by an oscillating plate." ScienceDaily. ScienceDaily, 12 September 2012. <www.sciencedaily.com/releases/2012/09/120912093208.htm>.
American Institute of Physics (AIP). (2012, September 12). Cells surf through a microfluidic chip on fluid streamlines created by an oscillating plate. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2012/09/120912093208.htm
American Institute of Physics (AIP). "Cells surf through a microfluidic chip on fluid streamlines created by an oscillating plate." ScienceDaily. www.sciencedaily.com/releases/2012/09/120912093208.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins