Featured Research

from universities, journals, and other organizations

Insulin: Charting the SH2 pool

Date:
September 13, 2012
Source:
BioMed Central Limited
Summary:
New research describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with SH2 domains underlying insulin (Ins), insulin-like growth factor-1 (IGF-1) and fibroblast growth factor (FGF) signaling pathways.

New research published in BioMed Central's open access journal Cell Communication and Signaling describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with SH2 domains underlying insulin (Ins), insulin-like growth factor-1 (IGF-1) and fibroblast growth factor (FGF) signaling pathways.

In the control of cell signaling pathways SH2 domains can be thought of as a master connector and tyrosine kinases the switch. SH2 domains interact with phosphorylated tyrosine containing peptides on receptors and other signaling molecules and couple the kinase to the next protein in the signaling chain.

The human genome contains 111 SH2 domain containing proteins which bind to activated protein tyrosine kinases (PTK). These cell signaling pathways are involved in embryonic development and their mis-regulation is implicated in a wide range of cancers, immunodeficiences and even diabetes.

A panel of 50 SH2 domains was screened for binding against a set of 192 human phosphotyrosine peptides from the FGF and Ins/IGF-1 pathways and found an extensive interactome consisting of over 500 interactions, most of which are novel.

The pool also highlighted the selectivity of individual SH2 domains. Six general classes of SH2 domain specificity were found which demonstrate not only the evolutionary similarities between SH2 domains in the same family of proteins but across families as well. The study also found subtle differences which could potentially control specificity.

Dr Piers Nash, from The University of Chicago, who led this study observed, "Our study of pTyr binding by SH2 domains is a valuable insight into the selectivity that underpins complex signaling networks. Understanding these signaling systems is a vitally important step towards explaining pathologies such as diabetes and cancer, as well as normal physiology and development."

He continued, "Every cell in our body is an immensely powerful computational device capable of integrating millions of factors and responding with remarkable fidelity. What lies beneath this computational power is not static wires, but dynamic interactions that leverage a finite number of genes to generate an almost infinite number of combinatorial interactions between the protein components that are at the heart of cellular signaling. Mapping the immensely complex set of interactions between the parts laid out by the genetic code represents a next frontier for biomedical science."


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bernard A Liu, Brett W Engelmann, Karl Jablonowski, Katherine Higginbotham, Andrew B Stergachis and Piers D Nash. SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. Cell Communication and Signaling, 2012 DOI: 10.1186/1478-811X-10-27

Cite This Page:

BioMed Central Limited. "Insulin: Charting the SH2 pool." ScienceDaily. ScienceDaily, 13 September 2012. <www.sciencedaily.com/releases/2012/09/120913203655.htm>.
BioMed Central Limited. (2012, September 13). Insulin: Charting the SH2 pool. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2012/09/120913203655.htm
BioMed Central Limited. "Insulin: Charting the SH2 pool." ScienceDaily. www.sciencedaily.com/releases/2012/09/120913203655.htm (accessed July 29, 2014).

Share This




More Plants & Animals News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
Asteroid's Timing Was 'Colossal Bad Luck' For The Dinosaurs

Asteroid's Timing Was 'Colossal Bad Luck' For The Dinosaurs

Newsy (July 28, 2014) The asteroid that killed the dinosaurs struck at the worst time for them. A new study says that if it hit earlier or later, they might've survived. Video provided by Newsy
Powered by NewsLook.com
Raw: Sea Turtle Hatchlings Emerge from Nest

Raw: Sea Turtle Hatchlings Emerge from Nest

AP (July 27, 2014) A live-streaming webcam catches loggerhead sea turtle hatchlings emerging from a nest in the Florida Keys. (July 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins