Featured Research

from universities, journals, and other organizations

Insulin: Charting the SH2 pool

Date:
September 13, 2012
Source:
BioMed Central Limited
Summary:
New research describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with SH2 domains underlying insulin (Ins), insulin-like growth factor-1 (IGF-1) and fibroblast growth factor (FGF) signaling pathways.

New research published in BioMed Central's open access journal Cell Communication and Signaling describes a large set of interactions (interactome) which maps the range of phosphotyrosine (pTyr)-dependent interactions with SH2 domains underlying insulin (Ins), insulin-like growth factor-1 (IGF-1) and fibroblast growth factor (FGF) signaling pathways.

In the control of cell signaling pathways SH2 domains can be thought of as a master connector and tyrosine kinases the switch. SH2 domains interact with phosphorylated tyrosine containing peptides on receptors and other signaling molecules and couple the kinase to the next protein in the signaling chain.

The human genome contains 111 SH2 domain containing proteins which bind to activated protein tyrosine kinases (PTK). These cell signaling pathways are involved in embryonic development and their mis-regulation is implicated in a wide range of cancers, immunodeficiences and even diabetes.

A panel of 50 SH2 domains was screened for binding against a set of 192 human phosphotyrosine peptides from the FGF and Ins/IGF-1 pathways and found an extensive interactome consisting of over 500 interactions, most of which are novel.

The pool also highlighted the selectivity of individual SH2 domains. Six general classes of SH2 domain specificity were found which demonstrate not only the evolutionary similarities between SH2 domains in the same family of proteins but across families as well. The study also found subtle differences which could potentially control specificity.

Dr Piers Nash, from The University of Chicago, who led this study observed, "Our study of pTyr binding by SH2 domains is a valuable insight into the selectivity that underpins complex signaling networks. Understanding these signaling systems is a vitally important step towards explaining pathologies such as diabetes and cancer, as well as normal physiology and development."

He continued, "Every cell in our body is an immensely powerful computational device capable of integrating millions of factors and responding with remarkable fidelity. What lies beneath this computational power is not static wires, but dynamic interactions that leverage a finite number of genes to generate an almost infinite number of combinatorial interactions between the protein components that are at the heart of cellular signaling. Mapping the immensely complex set of interactions between the parts laid out by the genetic code represents a next frontier for biomedical science."


Story Source:

The above story is based on materials provided by BioMed Central Limited. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bernard A Liu, Brett W Engelmann, Karl Jablonowski, Katherine Higginbotham, Andrew B Stergachis and Piers D Nash. SRC Homology 2 Domain Binding Sites in Insulin, IGF-1 and FGF receptor mediated signaling networks reveal an extensive potential interactome. Cell Communication and Signaling, 2012 DOI: 10.1186/1478-811X-10-27

Cite This Page:

BioMed Central Limited. "Insulin: Charting the SH2 pool." ScienceDaily. ScienceDaily, 13 September 2012. <www.sciencedaily.com/releases/2012/09/120913203655.htm>.
BioMed Central Limited. (2012, September 13). Insulin: Charting the SH2 pool. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2012/09/120913203655.htm
BioMed Central Limited. "Insulin: Charting the SH2 pool." ScienceDaily. www.sciencedaily.com/releases/2012/09/120913203655.htm (accessed August 23, 2014).

Share This




More Plants & Animals News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Endangered Red Wolves Face Uncertain Future

Endangered Red Wolves Face Uncertain Future

AP (Aug. 22, 2014) A federal judge temporarily banned coyote hunting to save endangered red wolves, but local hunters say that the wolf preservation program does more harm than good. Meanwhile federal officials are reviewing its wolf program in North Carolina. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Farm Resurgence Grows With Younger Crowd

Farm Resurgence Grows With Younger Crowd

AP (Aug. 22, 2014) New England farms are seeing a surge in younger farm hands as the 'buy local' food movement grows across the country. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins