Featured Research

from universities, journals, and other organizations

Bone marrow holds secrets for treating colitis and Crohn's

Date:
September 24, 2012
Source:
Michigan State University
Summary:
Researchers have unlocked secrets in bone marrow that could lead to improved treatments for colitis and Crohn's disease. The results show that the havoc inflammatory bowel diseases wreaks on the digestive tract is mirrored in bone marrow. Early indications also show that the disorders of the gut could potentially be treated through the bone marrow.

Michigan State University researchers have unlocked secrets in bone marrow that could lead to improved treatments for colitis and Crohn's disease.

The results, featured in the current issue of Proceedings of the National Academy of the Sciences, show that the havoc inflammatory bowel diseases wreaks on the digestive tract is mirrored in bone marrow. Early indications also show that the disorders of the gut could potentially be treated through the bone marrow, said Pam Fraker, MSU University Distinguished Professor of biochemistry and molecular biology.

"It's possible that if we could reduce bone marrow's ability to produce inflammatory cells that we could reduce the severity of colitis and Crohn's disease," said Fraker, who co-authored the study with MSU colleagues Laura McCabe, professor of physiology and radiology, and Mark Trottier, research specialist. "This could limit the damage that the disease causes and reduce the number of patients needing surgery."

Colitis and Crohn's affect more than a million people in the United States, including a growing number of children. There are no preventive treatments; however, steroids are often prescribed to reduce the diseases' pain and inflammation. The side effect of this course is tissue damage, which could lead to surgery and additional complications.

Watching a young patient suffer through the pain of severe colitis bolstered Fraker's need to research this devastating disease.

"She was very frail, sick, addicted to narcotics to numb her pain and had several intestinal surgeries to no avail," Fraker said. "This became a huge motivator for me as it drove home how little real help is available to these patients."

Fraker focused on bone marrow, which is a large, highly active and responsive tissue. When colitis was induced in mice, she was surprised by the significant and swift changes that occurred in their bone marrow. The symptoms of colitis, such as swelling, anemia and unhealthy increases in monocytes and neutrophils, (cells that fight infection but exacerbate the excessive swelling in intestines) were reflected in the bone marrow.

The bone marrow's reactions actually fan the flames of the inflammatory bowel diseases rather than help cure it. When bone marrow amps up production of monocytes and neutrophils, it does it at the expense of making lymphocytes and red blood cells, keys to immune defense.

The research was funded in part by the Crohn's and Colitis Foundation.


Story Source:

The above story is based on materials provided by Michigan State University. Note: Materials may be edited for content and length.


Cite This Page:

Michigan State University. "Bone marrow holds secrets for treating colitis and Crohn's." ScienceDaily. ScienceDaily, 24 September 2012. <www.sciencedaily.com/releases/2012/09/120924152547.htm>.
Michigan State University. (2012, September 24). Bone marrow holds secrets for treating colitis and Crohn's. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2012/09/120924152547.htm
Michigan State University. "Bone marrow holds secrets for treating colitis and Crohn's." ScienceDaily. www.sciencedaily.com/releases/2012/09/120924152547.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins