Featured Research

from universities, journals, and other organizations

Implant-based breast reconstruction following radiation has high patient satisfaction rate despite complications

Date:
October 2, 2012
Source:
Wolters Kluwer Health: Lippincott Williams & Wilkins
Summary:
Breast cancer patients who have received radiation therapy after mastectomy have more problems related to the use of implants for breast reconstruction, according to a new review.

Breast cancer patients who have received radiation therapy after mastectomy have more problems related to the use of implants for breast reconstruction, according to a review in the October issue of Plastic and Reconstructive Surgeryฎ, the official medical journal of the American Society of Plastic Surgeons (ASPS).

Although women should be aware of these increased risks, implant-based breast reconstruction after radiation therapy is still successful in most cases, according to the paper by Dr. Steven J. Kronowitz of The University of Texas MD Anderson Cancer Center, Houston.

Breast Implants after Radiation Carry Increased Risks

Dr. Kronowitz reviews and synthesizes recent research on breast reconstruction using implants for patients receiving radiation therapy. To reduce the risk of recurrent breast cancer, increasing numbers of women are being treated with radiation therapy after mastectomy (postmastectomy radiation therapy, or PMRT). Radiation has toxic effects on tissues that can cause problems with healing.

Reconstructive surgeons agree that breast reconstruction results after radiation therapy tend to be better when the patient's own (autologous) tissue is used. However, in some situations implants may be the preferred option for reconstruction, or the only choice. The goal of the review was to analyze the best available evidence on the use of breast implants after radiation therapy.

Dr. Kronowitz identified 19 studies, of varying quality, evaluating the results of implant-based reconstruction in patients receiving PMRT. He writes, "In general, radiation increases the risk of complications and poor aesthetic outcomes of implant-based reconstruction."

In one of the largest studies performed to date, the risk of major complications was about 45 percent for women receiving implants with radiation therapy, compared to 24 percent in patients not exposed to radiation. Complications were more common when radiation was given before versus after implant-based reconstruction: 64 versus 58 percent.

The highest-quality study found that, among women undergoing implant reconstruction, patient satisfaction scores were lower for those receiving radiation therapy. Another study reported that women receiving implants after radiation therapy were more likely to need major corrective surgery.

Newer Techniques May Lead to Improved Results

One paper suggested that radiation-related skin damage predicted higher complication rates and poorer aesthetic outcomes after implant-based reconstruction. Some recent research indicated that the results of implant reconstruction after PMRT could be improved by the addition of autologous fat transfer -- using the patient's own fat tissue to enhance the results.

"Despite advances in reconstructive devices and materials, PMRT still appears to have an adverse impact on outcomes of implant-based breast reconstruction," Dr. Kronowitz writes. "However," he adds," the majority of patients who undergo implant-based reconstruction and PMRT ultimately keep the implant-based reconstruction." Outcomes appear better with two-stage reconstruction, where the implant is placed after PMRT, rather than immediately after mastectomy.

Autologous fat grafting and other new approaches hold promise for improving the results of implant-based reconstruction after radiation therapy for breast cancer, Dr. Kronowitz believes. "In the meantime, patients who will receive or have received radiation should be advised of the risks of implant-based breast reconstruction." In an upcoming article, Dr. Kronowitz will review recent data on the results of autologous tissue-based breast reconstruction after radiation therapy.


Story Source:

The above story is based on materials provided by Wolters Kluwer Health: Lippincott Williams & Wilkins. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kronowitz, Steven J. Current Status of Implant-Based Breast Reconstruction in Patients Receiving Postmastectomy Radiation Therapy. Plastic & Reconstructive Surgery, October 2012 - Volume 130 - Issue 4 - p 513e%u2013524e DOI: 10.1097/PRS.0b013e318262f059

Cite This Page:

Wolters Kluwer Health: Lippincott Williams & Wilkins. "Implant-based breast reconstruction following radiation has high patient satisfaction rate despite complications." ScienceDaily. ScienceDaily, 2 October 2012. <www.sciencedaily.com/releases/2012/10/121002143451.htm>.
Wolters Kluwer Health: Lippincott Williams & Wilkins. (2012, October 2). Implant-based breast reconstruction following radiation has high patient satisfaction rate despite complications. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2012/10/121002143451.htm
Wolters Kluwer Health: Lippincott Williams & Wilkins. "Implant-based breast reconstruction following radiation has high patient satisfaction rate despite complications." ScienceDaily. www.sciencedaily.com/releases/2012/10/121002143451.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) — New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) — Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) — Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) — Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins