Featured Research

from universities, journals, and other organizations

Liquorice offers clue to cleaner medical implants

Date:
October 8, 2012
Source:
Elsevier
Summary:
A new coating utilizing nanotechnology will allow surgeons to sterilize medical devices that contain biological components. A nanotech material containing an extract from liquorice can be used to sterilize and protect medical devices and implants which include biological components, and protects these functional bio-components during the sterilization process.

A new coating utilizing nanotechnology will allow surgeons to sterilize medical devices that contain biological components.

A nanotech material containing an extract from liquorice can be used to sterilize and protect medical devices and implants which include biological components, and protects these functional bio-components during the sterilization process.

Publishing their findings in the latest issue of Materials Today, a team of researchers from Germany and Austria explain how conventional sterilization techniques based on a blast of radiation, or exposure to toxic gas can damage the functional biological components of the device. The coating, containing a component found in liquorice and developed by German biotech company LEUKOCARE AG, protects these sensitive components.

Joachim Koch of the Georg-Speyer Haus, Institute for Biomedical Research in Frankfurt am Main in Germany and colleagues explain how medical devices and implants are increasingly functionalized using pharmacologically active proteins, antibodies and other biomolecules. Harsh sterilization procedures, including beta and gamma irradiation or exposure to toxic ethylene oxide can damage these sensitive molecules and render the device useless. However, without sterilization the patient is at risk of infection when the device is used or implanted.

The team has now successfully evaluated the nano-coating; a technology which employs a composition of stabilizing nano-molecules. One important ingredient is a compound known as glycyrrhizic acid, a natural, sweet-tasting chemical found in liquorice. Unlike other stabilizing approaches used in biopharmaceutical formulations, the nano-coating contains no sugars, sugar-alcohol compounds or proteins that might otherwise interfere with the biological activity of the device.

The team has tested the nano-coating by coupling and stabilizing an anti-inflammatory antibody to a porous polyurethane surface. This carrier acts as a surrogate for a medical device. Such a system might be used as a therapeutic implant to reduce inflammation caused by an overactive immune system in severely ill patients. The researchers found that even if the test device is blasted with radiation to sterilize it entirely, neither the nano-coating nor the proteins are damaged by the radiation and the activity of the device is maintained.

"This nano-coating formulation can now be applied for the production of improved biofunctionalized medical devices such as bone implants, vascular stents, and wound dressings and will ease the application of biomedical combination products," Koch explains.


Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rupert Tscheliessnig, Martin Zörnig, Eva M. Herzig, Katharina Lückerath, Jens Altrichter, Kristina Kemter, Adnana Paunel-Görgülü, Tim Lögters, Joachim Windolf, Silvia Pabisch, Jindrich Cinatl, Holger F. Rabenau, Alois Jungbauer, Peter Müller-Buschbaum, Martin Scholz, Joachim Koch. Nano-coating protects biofunctional materials. Materials Today, 2012; 15 (9): 394 DOI: 10.1016/S1369-7021(12)70166-9

Cite This Page:

Elsevier. "Liquorice offers clue to cleaner medical implants." ScienceDaily. ScienceDaily, 8 October 2012. <www.sciencedaily.com/releases/2012/10/121008091554.htm>.
Elsevier. (2012, October 8). Liquorice offers clue to cleaner medical implants. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2012/10/121008091554.htm
Elsevier. "Liquorice offers clue to cleaner medical implants." ScienceDaily. www.sciencedaily.com/releases/2012/10/121008091554.htm (accessed September 16, 2014).

Share This



More Matter & Energy News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Manufacturer Prints 3-D Car In Record Time

Manufacturer Prints 3-D Car In Record Time

Newsy (Sep. 15, 2014) — Automobile manufacturer Local Motors created a drivable electric car using a 3-D printer. Printing the body only took 44 hours. Video provided by Newsy
Powered by NewsLook.com
Refurbished New York Subway Tunnel Unveiled After Sandy Damage

Refurbished New York Subway Tunnel Unveiled After Sandy Damage

Reuters - US Online Video (Sep. 15, 2014) — New York officials unveil subway tunnels that were refurbished after Superstorm Sandy. Nathan Frandino reports. Video provided by Reuters
Powered by NewsLook.com
Frustration As Drone Industry Outpaces Regulation In U.S.

Frustration As Drone Industry Outpaces Regulation In U.S.

Newsy (Sep. 14, 2014) — U.S. firms worry they’re falling behind in the marketplace as the FAA considers how to regulate commercial drones. Video provided by Newsy
Powered by NewsLook.com
Smart Gun Innovators Fear Backlash From Gun Rights Advocates

Smart Gun Innovators Fear Backlash From Gun Rights Advocates

Newsy (Sep. 14, 2014) — Winners of a contest for smart gun design are asking not to be named after others in the industry received threats for marketing similar products. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins