Featured Research

from universities, journals, and other organizations

Chaperone protein subverts removal of glaucoma-causing protein

Date:
October 9, 2012
Source:
University of South Florida (USF Health)
Summary:
The chaperone protein Grp94 can interfere with the clearance of another protein known to cause the glaucoma when mutated, a new study has found. The researchers also demonstrated that a new specific inhibitor of Grp94 facilitates clearance of the genetically-defective protein, called myocilin, from cells.

The chaperone protein Grp94 can interfere with the clearance of another protein known to cause the glaucoma when mutated, a new study led by researchers at the University of South Florida has found. Using a cell model, the researchers also demonstrated that a new specific inhibitor of Grp94 facilitates clearance of the genetically-defective protein, called myocilin, from cells.

Reported online this month in JBC (The Journal of Biological Chemistry), the discoveries could lead to a new treatment for some hereditary cases of glaucoma, an eye disease that is a leading cause of blindness, said prinicipal investigator Chad Dickey, PhD, associate professor of molecular medicine at the USF Health Byrd Alzheimer's Institute.

"When mutated, the glaucoma-causing protein becomes toxic to a cell network known as the trabecular meshwork cells that regulate pressure within the eye," Dickey said. "Once these cells die, the ocular pressure increases, causing glaucoma."

Genetic defects of myocilin account for approximately 8 to 36 percent of hereditary juvenile-onset glaucoma and 5 to 10 percent of adult-onset hereditary glaucoma.

The researchers suggest that mutant myocilin, triggered by an interaction with the chaperone Grp94, is highly resistant to degradation, thus clogging the protein quality control pathway and subverting efficient removal of the glaucoma-causing protein. So, the development of targeted therapies to inhibit Grp94 may be beneficial for patients suffering from myocilin glaucoma.

USF researchers from the Department of Molecular Medicine and College of Pharmacy worked on the study, which was supported by the National Institutes of Health and the American Health Assistance Foundation. They collaborated with scientists from the National Eye Institute, Georgia Institute of Technology and University of Kansas.


Story Source:

The above story is based on materials provided by University of South Florida (USF Health). The original article was written by Anne DeLotto Baier. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. Suntharalingam, J. F. Abisambra, J. C. O'Leary, J. Koren, B. Zhang, M. K. Joe, L. J. Blair, S. E. Hill, U. K. Jinwal, M. Cockman, A. S. Duerfeldt, S. Tomarev, B. S. J. Blagg, R. L. Lieberman, C. A. Dickey. Grp94 triage of mutant myocilin through ERAD subverts a more efficient autophagic clearance mechanism. Journal of Biological Chemistry, 2012; DOI: 10.1074/jbc.M112.384800

Cite This Page:

University of South Florida (USF Health). "Chaperone protein subverts removal of glaucoma-causing protein." ScienceDaily. ScienceDaily, 9 October 2012. <www.sciencedaily.com/releases/2012/10/121009121605.htm>.
University of South Florida (USF Health). (2012, October 9). Chaperone protein subverts removal of glaucoma-causing protein. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2012/10/121009121605.htm
University of South Florida (USF Health). "Chaperone protein subverts removal of glaucoma-causing protein." ScienceDaily. www.sciencedaily.com/releases/2012/10/121009121605.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins