Featured Research

from universities, journals, and other organizations

Cause of high cholesterol discovered

Date:
October 28, 2012
Source:
Heart and Stroke Foundation of Canada
Summary:
A protein called resistin, secreted by fat tissue, causes high levels of "bad" cholesterol, increasing the risk of heart disease.

Canadian scientists have discovered that a protein called resistin, secreted by fat tissue, causes high levels of "bad" cholesterol (low-density lipoprotein or LDL), increasing the risk of heart disease.

The research, presented October 28 at the Canadian Cardiovascular Congress, proves that resistin increases the production of LDL in human liver cells and also degrades LDL receptors in the liver. As a result, the liver is less able to clear "bad" cholesterol from the body. Resistin accelerates the accumulation of LDL in arteries, increasing the risk of heart disease.

The research also shows that resistin adversely impacts the effects of statins, the main cholesterol-reducing drug used in the treatment and prevention of cardiovascular disease.

Dr. Shirya Rashid -- senior author of the study and assistant professor in the department of medicine at McMaster University -- notes that a staggering 40 per cent of people taking statins are resistant to their impact on lowering blood LDL.

"The bigger implication of our results is that high blood resistin levels may be the cause of the inability of statins to lower patients' LDL cholesterol," says Dr. Rashid.

She believes the discovery could lead to revolutionary new therapeutic drugs, especially those that target and inhibit resistin and thereby increase the effectiveness of statins.

"The possibilities for improved therapy for the causes of cardiovascular disease are very important," says Heart and Stroke Foundation spokesperson Dr. Beth Abramson. "About 40 per cent of Canadians have high blood cholesterol levels: it's a significant health concern in Canada."

Dr. Abramson notes that the research reconfirms the importance of maintaining a healthy weight and cholesterol level, two critical factors in the prevention of heart disease.

High blood cholesterol is a major risk factor for heart disease and stroke. It can lead to a buildup of plaque in the artery walls and narrowing of the arteries, causing a condition called atherosclerosis which can make it more difficult for blood to flow through the heart and body.

Being overweight also increases the likelihood of high blood pressure and diabetes, compounding the risks of heart disease and stroke.

"Fortunately, we know a great deal about heart disease prevention and how to reverse some of the risks," says Dr. Abramson. She urges Canadians to maintain their heart health through regular visits to their doctor, monitoring their weight and waist size, eating a variety of nutritious, low-fat foods and being physically active. "It's equally important to take your medications as directed by your physician to help further reduce risks."


Story Source:

The above story is based on materials provided by Heart and Stroke Foundation of Canada. Note: Materials may be edited for content and length.


Cite This Page:

Heart and Stroke Foundation of Canada. "Cause of high cholesterol discovered." ScienceDaily. ScienceDaily, 28 October 2012. <www.sciencedaily.com/releases/2012/10/121028141717.htm>.
Heart and Stroke Foundation of Canada. (2012, October 28). Cause of high cholesterol discovered. ScienceDaily. Retrieved April 20, 2014 from www.sciencedaily.com/releases/2012/10/121028141717.htm
Heart and Stroke Foundation of Canada. "Cause of high cholesterol discovered." ScienceDaily. www.sciencedaily.com/releases/2012/10/121028141717.htm (accessed April 20, 2014).

Share This



More Health & Medicine News

Sunday, April 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) — Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) — In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) — A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) — The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins