Featured Research

from universities, journals, and other organizations

Capturing living cells in micro pyramids

Date:
November 21, 2012
Source:
University of Twente
Summary:
Imagine a field full of pyramids, but on a micro scale. Each of the pyramids hides a living cell. Thanks to 3-D micro- and nano-scale fabrication, this is possible and there are promising new applications in the offing. One of them is applying the micro pyramids for cell research: thanks to the open 'walls' of the pyramids, the cells can interact.

3-D nanofabrication of fluidic components by corner lithography.
Credit: Image courtesy of University of Twente

Imagine a field full of pyramids, but on a micro scale. Each of the pyramids hides a living cell. Thanks to 3-D micro- and nano-scale fabrication, this is possible and there are promising new applications in the offing. One of them is applying the micro pyramids for cell research: thanks to the open 'walls' of the pyramids, the cells can interact.

Scientists of the research institutes MESA+ and MIRA of the University of Twente in The Netherlands present this new technology and first applications in the journal Small.

Most cell studies take place in 2-D: this is not a natural situation, because cells organize themselves in differently in the human body. If you give the cells room to move in three dimensions, the set-up is closer to what we find in nature. This is possible in the 'open pyramids' fabricated in the NanoLab of the MESA+ Institute for Nanotechnology of the University of Twente.

Tiny corner remains filled

If you join a number of flat silicon surfaces to form a sharp corner, it is possible to deposit another material on them. After having removed the the bulk of the material, however, a small amount of material remains in the corner. This tiny tip can be used for an Atomic Force Microscope, or, in this case, for forming a micro pyramid.

Catching cells

In cooperation with UT's MIRA Institute for Biomedical Technology and Technical Medicine, the nanoscientists have explored the possibilities of applying the pyramids as 'cages' for cells. First experiments with polystyrene balls worked out well. The next experiments involved capturing chondrocytes, cells forming cartilage. Moved by capillary fluid flow, these cells automatically 'fall' into the pyramid through a hole at the bottom. Soon after they settle in their 3-D cage, cells begin to interact with cells in adjacent pyramids. Changes in the phenotype of the cell can now be studied in a better way than in the usual 2-D situation. It is therefore a promising tool to be used in tissue regeneration research.

The Dutch scientists expect to develop extensions to this technology: the edges of the pyramid can be made hollow and function as fluid channels. Between the pyramids, it is also possible to create nanofluidic channels, which could be used to feed the cells.


Story Source:

The above story is based on materials provided by University of Twente. Note: Materials may be edited for content and length.


Journal Reference:

  1. Erwin J. W. Berenschot, Narges Burouni, Bart Schurink, Joost W. van Honschoten, Remco G. P. Sanders, Roman Truckenmuller, Henri V. Jansen, Miko C. Elwenspoek, Aart A. van Apeldoorn, Niels R. Tas. 3D Nanofabrication of Fluidic Components by Corner Lithography. Small, 2012; DOI: 10.1002/smll.201201446

Cite This Page:

University of Twente. "Capturing living cells in micro pyramids." ScienceDaily. ScienceDaily, 21 November 2012. <www.sciencedaily.com/releases/2012/11/121121130701.htm>.
University of Twente. (2012, November 21). Capturing living cells in micro pyramids. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2012/11/121121130701.htm
University of Twente. "Capturing living cells in micro pyramids." ScienceDaily. www.sciencedaily.com/releases/2012/11/121121130701.htm (accessed July 25, 2014).

Share This




More Plants & Animals News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How to Make Single Serving Smoothies: Howdini Hacks

How to Make Single Serving Smoothies: Howdini Hacks

Howdini (July 24, 2014) Smoothies are a great way to get in lots of healthy ingredients, plus they taste great! Howdini has a trick for making the perfect single-size smoothie that will save you time on cleanup too! All you need is a blender and a mason jar. Video provided by Howdini
Powered by NewsLook.com
Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Newsy (July 24, 2014) A new study claims a set of prehistoric T-Rex footprints supports the theory that the giant predators hunted in packs instead of alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

    Health News

      Environment News

        Technology News



          Save/Print:
          Share:

          Free Subscriptions


          Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

          Get Social & Mobile


          Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

          Have Feedback?


          Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
          Mobile: iPhone Android Web
          Follow: Facebook Twitter Google+
          Subscribe: RSS Feeds Email Newsletters
          Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins