Featured Research

from universities, journals, and other organizations

Better blood transfusions for preterm babies

Date:
November 23, 2012
Source:
University of Adelaide
Summary:
Results of new research are a promising step forward in helping to improve the quality of life-saving blood transfusions for preterm babies, by reducing the likelihood of adverse inflammatory responses to the blood.

Results of new research from the University of Adelaide are a promising step forward in helping to improve the quality of life-saving blood transfusions for preterm babies, by reducing the likelihood of adverse inflammatory responses to the blood.

Blood transfusions are among the most common medical procedures experienced by preterm babies, who are often anemic and suffer blood loss.

Researchers from the University of Adelaide's Robinson Institute studied 28 preterm babies (at 28 weeks' gestation or less) who were given packed red blood cell transfusions. The results of this study are now published in the journal Pediatric Research.

"Blood transfusions are a safe and life-saving medical procedure -- they are an important part of modern-day medical care," says the lead author, Dr Michael Stark from the University of Adelaide's Robinson Institute.

"It has been suggested that blood transfusions themselves may be associated with medical complications that are unrelated to the reason for which the transfusion is given, and we don't really know why that is.

"These associations include bronchopulmonary dysplasia and necrotizing entercolitis, inflammatory conditions that affect the lungs and gut of very preterm babies."

The researchers have found a potential mechanism associated with the inflammatory response in the body.

"Within two to four hours of preterm babies receiving a blood transfusion, we have seen elevated levels of cytokines and chemokines -- signaling cells -- that stimulate inflammatory responses in the body," Dr Stark says.

"We believe that the bioactive components of packed red blood cell transfusions are initiating or amplifying these inflammatory processes in the body.

"We hope that by better understanding how the body responds to the blood, we can make improvements to blood transfusions that will reduce the likelihood of inflammatory responses. In this way, the patient will benefit from a life-saving procedure and also experience less complications as a result of that procedure.

"More research is now needed to determine exactly how this response is triggered, and how we might be able to prevent it," he says.


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amy K. Keir, Andrew J. McPhee, Chad C. Andersen, Michael J. Stark. Plasma cytokines and markers of endothelial activation increase after packed red blood cell transfusion in the preterm infant. Pediatric Research, 2012; DOI: 10.1038/pr.2012.144

Cite This Page:

University of Adelaide. "Better blood transfusions for preterm babies." ScienceDaily. ScienceDaily, 23 November 2012. <www.sciencedaily.com/releases/2012/11/121123132635.htm>.
University of Adelaide. (2012, November 23). Better blood transfusions for preterm babies. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2012/11/121123132635.htm
University of Adelaide. "Better blood transfusions for preterm babies." ScienceDaily. www.sciencedaily.com/releases/2012/11/121123132635.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins