Featured Research

from universities, journals, and other organizations

Gene therapy as a new option for bone defects

Date:
December 7, 2012
Source:
Medical University of Vienna
Summary:
Gene therapy involving modified stem cells obtained from fatty tissue and bone marrow could represent a new option for the treatment of severe orthopaedic injuries to the extremities. The treatment could in future prevent threatened amputations or massive shortenings of bones.

Martina Hauser-Schinhan.
Credit: Image courtesy of Medical University of Vienna

Gene therapy involving modified stem cells obtained from fatty tissue and bone marrow could represent a new option for the treatment of severe orthopaedic injuries to the extremities. This treatment has been developed by Martina Hauser-Schinhan from the University Department of Orthopaedics at the MedUni Vienna during a research fellowship at the Center for Advanced Orthopedic Studies at the Harvard Medical School. The treatment could in future prevent threatened amputations or massive shortenings of bones.

The new method involves altering the body's own stem cells, obtained from fat or bone marrow, with BMP-2 genes which are known to promote bone healing. The autologous stem cells that are genetically modified with ad.BMP-2 are embedded in a fibrin gel which is applied between the two broken parts of the bone. The stem cells continuously produce BMP-2, like a power plant. The stem cells and the BMP-2 cause the bones to heal. "Until now, in cases of severe injury that we would be able to treat with this method, amputations or bone shortening surgery were often necessary," says Hauser-Schinhan.

The new treatment option has been used in in vivo trials and clinical studies are set to follow. The results so far invite the conclusion that healing occurs within a few weeks. Says Hauser-Schinhan: "Even with normal bone fractures, it takes six weeks." Its use even after the removal of bony tumours, which involves taking away large portions of bone, appears to be possible according to the MedUni researcher.

Hauser-Schinhan carried out research at Harvard between April 2011 and April 2012. The local Center for Orthopedics, led by Christopher Evans, who has collaborated closely for many years with the Head of Department in Vienna Reinhard Windhager, is renowned for its work on gene therapy and its use in the healing of bone defects.


Story Source:

The above story is based on materials provided by Medical University of Vienna. Note: Materials may be edited for content and length.


Cite This Page:

Medical University of Vienna. "Gene therapy as a new option for bone defects." ScienceDaily. ScienceDaily, 7 December 2012. <www.sciencedaily.com/releases/2012/12/121207090428.htm>.
Medical University of Vienna. (2012, December 7). Gene therapy as a new option for bone defects. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2012/12/121207090428.htm
Medical University of Vienna. "Gene therapy as a new option for bone defects." ScienceDaily. www.sciencedaily.com/releases/2012/12/121207090428.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins