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From fish to human: Research reveals how fins became legs

Date:
December 10, 2012
Source:
Cell Press
Summary:
Vertebrates' transition to living on land, instead of only in water, represented a major event in the history of life. Now, researchers provide new evidence that the development of hands and feet occurred through the gain of new DNA elements that activate particular genes.

This zebrafish embryo developed a limb that looks more like a leg than a fin, after being engineered to produce the HoxD13 protein within the cells at the tip of the developing fin. Changes in HoxD13 production likely contributed to the transition from fin to leg development, during animal evolution.
Credit: Freitas et al., Developmental Cell

Vertebrates' transition to living on land, instead of only in water, represented a major event in the history of life. Now, researchers reporting in the December issue of the Cell Press journal Developmental Cell provide new evidence that the development of hands and feet occurred through the gain of new DNA elements that activate particular genes.

"First, and foremost, this finding helps us to understand the power that the modification of gene expression has on shaping our bodies," says Dr. José Luis Gómez-Skarmeta of the CSIC-Universidad Pablo de Olavide-Junta de Andalucía, in Seville, Spain. "Second, many genetic diseases are associated with a 'misshaping' of our organs during development. In the case of genes involved in limb formation, their abnormal function is associated with diseases such as synpolydactyly and hand-foot-genital syndrome."

In order to understand how fins may have evolved into limbs, researchers led by Dr. Gómez-Skarmeta and his colleague Dr. Fernando Casares at the same institute introduced extra Hoxd13, a gene known to play a role in distinguishing body parts, at the tip of a zebrafish embryo's fin. Surprisingly, this led to the generation of new cartilage tissue and the reduction of fin tissue -- changes that strikingly recapitulate key aspects of land-animal limb development. The researchers wondered whether novel Hoxd13 control elements may have increased Hoxd13 gene expression in the past to cause similar effects during limb evolution. They turned to a DNA control element that is known to regulate the activation of Hoxd13 in mouse embryonic limbs and that is absent in fish.

"We found that in the zebrafish, the mouse Hoxd13 control element was capable of driving gene expression in the distal fin rudiment. This result indicates that molecular machinery capable of activating this control element was also present in the last common ancestor of finned and legged animals and is proven by its remnants in zebrafish," says Dr. Casares.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Renata Freitas, Carlos Gómez-Marín, Jonathan Mark Wilson, Fernando Casares, José Luis Gómez-Skarmeta. Hoxd13 Contribution to the Evolution of Vertebrate Appendages. Developmental Cell, 2012; 23 (6): 1219 DOI: 10.1016/j.devcel.2012.10.015

Cite This Page:

Cell Press. "From fish to human: Research reveals how fins became legs." ScienceDaily. ScienceDaily, 10 December 2012. <www.sciencedaily.com/releases/2012/12/121210124521.htm>.
Cell Press. (2012, December 10). From fish to human: Research reveals how fins became legs. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2012/12/121210124521.htm
Cell Press. "From fish to human: Research reveals how fins became legs." ScienceDaily. www.sciencedaily.com/releases/2012/12/121210124521.htm (accessed September 17, 2014).

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