Featured Research

from universities, journals, and other organizations

How airway cells regenerate after chlorine gas injury

Date:
December 19, 2012
Source:
University of Louisville
Summary:
Scientists have uncovered new clues in understanding how epithelial cells -- the cells that line the trachea, bronchi and other airways that carry air in and out of the lung -- repair themselves after chlorine gas exposure.

Scarring of the airways can lead to long-term breathing problems for some people exposed to high levels of chlorine gas from events such as an industrial accident, chemical spill following a train derailment or terroristic chemical warfare. Household mishaps from mixing bleach with acidic cleaning products also can cause release of chlorine gas; if this occurs in a poorly ventilated space, chlorine levels could be high enough to cause lung injury.

University of Louisville scientist Gary Hoyle, Ph.D., School of Public Health and Information Sciences Department of Environmental and Occupational Health Sciences, and his team have uncovered new clues in understanding how epithelial cells -- the cells that line the trachea, bronchi and other airways that carry air in and out of the lung -- repair themselves after chlorine gas exposure. The findings were recently published in the American Journal of Physiology -- Lung Cellular and Molecular Physiology in the article, Differential Susceptibility of Inbred Mouse Strains to Chlorine-Induced Airway Fibrosis. The research is funded by the National Institutes of Health (NIH) CounterACT program.

"The repair of injured epithelial cells is necessary to restore normal lung structure and function," Hoyle said. "The goal is to prevent scarring or fibrosis in the airways. It is a race between new epithelial cell growth and scar tissue development, and it takes about five to seven days after chlorine exposure for that to begin."

Following chlorine-related injury, Hoyle found that a type of epithelial cells called basal cells initiated the repair and served as progenitor cells -- early descendants of stem cells that can differentiate to form one or more cell types. The progenitor cells helped restore new tissue in the airways.

"Structural changes in the respiratory system are difficult to reverse, so understanding how cells function and multiply can help us develop treatments to prevent scarring and subsequent asthma-like breathing problems that affect for a life time some people who've experienced high levels of chlorine exposure," Hoyle said.

This type of lung injury also can be caused by other types of industrial chemicals including ammonia, methylisocyanate and sulfur dioxide.


Story Source:

The above story is based on materials provided by University of Louisville. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y. Mo, J. Chen, C. F. Schlueter, G. W. Hoyle. Differential Susceptibility of Inbred Mouse Strains to Chlorine-Induced Airway Fibrosis. AJP: Lung Cellular and Molecular Physiology, 2012; DOI: 10.1152/ajplung.00272.2012

Cite This Page:

University of Louisville. "How airway cells regenerate after chlorine gas injury." ScienceDaily. ScienceDaily, 19 December 2012. <www.sciencedaily.com/releases/2012/12/121219084223.htm>.
University of Louisville. (2012, December 19). How airway cells regenerate after chlorine gas injury. ScienceDaily. Retrieved August 20, 2014 from www.sciencedaily.com/releases/2012/12/121219084223.htm
University of Louisville. "How airway cells regenerate after chlorine gas injury." ScienceDaily. www.sciencedaily.com/releases/2012/12/121219084223.htm (accessed August 20, 2014).

Share This




More Health & Medicine News

Wednesday, August 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com
101-Year-Old Working Man Has All The Advice You Need

101-Year-Old Working Man Has All The Advice You Need

Newsy (Aug. 19, 2014) Herman Goldman has worked at the same lighting store for almost 75 years. Find out his secrets to a happy, productive life. Video provided by Newsy
Powered by NewsLook.com
Researcher Testing on-Field Concussion Scanners

Researcher Testing on-Field Concussion Scanners

AP (Aug. 19, 2014) Four Texas high school football programs are trying out an experimental system designed to diagnose concussions on the field. The technology is in response to growing concern over head trauma in America's most watched sport. (Aug. 19) Video provided by AP
Powered by NewsLook.com
American Ebola Patient Apparently Improving, Outbreak Is Not

American Ebola Patient Apparently Improving, Outbreak Is Not

Newsy (Aug. 19, 2014) Nancy Writebol, an American missionary who contracted Ebola, is apparently getting better, according to her husband. The outbreak, however, is not. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins