Featured Research

from universities, journals, and other organizations

Lower thresholds for blood transfusion found to have no adverse effects on patients' health

Date:
January 2, 2013
Source:
Robert Wood Johnson Medical School
Summary:
A systematic review of 19 clinical trials comparing higher versus lower hemoglobin thresholds in red blood cell transfusion concludes that there is no significant difference in patient outcomes with red blood cell transfusions using lower threshold levels.

The level at which red blood cells are transfused, a common treatment in clinical practice, is often deliberated among physicians. Guidelines for blood transfusion levels were only recently issued in March 2012 diminishing some of the debate. Today, in a new section called JAMA Clinical Evidence Synopsis, the Journal of the American Medical Association (JAMA), published a summary of the systematic review of the 19 clinical trials that compare higher versus lower hemoglobin thresholds in red blood cell transfusion. The comprehensive review concludes that there is no significant difference in patient outcomes with red blood cell transfusions using lower threshold levels.

"Our systematic review of these clinical trials resolves that the use of a restrictive approach to blood transfusions is safe for most patients," said Jeffrey L. Carson, MD, the Richard C. Reynolds Professor of Medicine at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and lead author of the JAMA manuscript. "The evidence provided in the synopsis can be used to treat anemic patients in both critical and acute care settings without concern of causing undue harm."

More than 6,000 patients with a mean age of 63 years old were part of the 19 studies included in the systematic review, which showed that death did not increase in patients given a lower threshold blood transfusion. Nor was there a significant difference in major complications such as pneumonia, stroke, infection or pulmonary edema.

"Outcomes Using Lower vs. Higher Hemoglobin Thresholds for Red Blood Cell Transfusion" is the inaugural article in JAMA's Clinical Evidence Synopsis section, which will include summaries of large-scale systematic reviews of similar studies. The briefs provide physicians with access to evidence-based information that can be quickly used to improve patient care.

Dr. Carson developed the blood transfusion guidelines along with specialists in cardiology, pediatrics, critical care medicine, trauma and anesthesia that were issued last March by the AABB (formerly the American Association of Blood Banks). He was lead author on two of the clinical trials included in this Clinical Evidence Synopsis.


Story Source:

The above story is based on materials provided by Robert Wood Johnson Medical School. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carson JL, Carless PA, Hιbert PC. Outcomes Using Lower vs Higher Hemoglobin Thresholds for Red Blood Cell Transfusion. JAMA, 2013; 309 (1): 83-84 DOI: 10.1001/jama.2012.50429

Cite This Page:

Robert Wood Johnson Medical School. "Lower thresholds for blood transfusion found to have no adverse effects on patients' health." ScienceDaily. ScienceDaily, 2 January 2013. <www.sciencedaily.com/releases/2013/01/130102161113.htm>.
Robert Wood Johnson Medical School. (2013, January 2). Lower thresholds for blood transfusion found to have no adverse effects on patients' health. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2013/01/130102161113.htm
Robert Wood Johnson Medical School. "Lower thresholds for blood transfusion found to have no adverse effects on patients' health." ScienceDaily. www.sciencedaily.com/releases/2013/01/130102161113.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) — Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins