Featured Research

from universities, journals, and other organizations

Lower thresholds for blood transfusion found to have no adverse effects on patients' health

Date:
January 2, 2013
Source:
Robert Wood Johnson Medical School
Summary:
A systematic review of 19 clinical trials comparing higher versus lower hemoglobin thresholds in red blood cell transfusion concludes that there is no significant difference in patient outcomes with red blood cell transfusions using lower threshold levels.

The level at which red blood cells are transfused, a common treatment in clinical practice, is often deliberated among physicians. Guidelines for blood transfusion levels were only recently issued in March 2012 diminishing some of the debate. Today, in a new section called JAMA Clinical Evidence Synopsis, the Journal of the American Medical Association (JAMA), published a summary of the systematic review of the 19 clinical trials that compare higher versus lower hemoglobin thresholds in red blood cell transfusion. The comprehensive review concludes that there is no significant difference in patient outcomes with red blood cell transfusions using lower threshold levels.

Related Articles


"Our systematic review of these clinical trials resolves that the use of a restrictive approach to blood transfusions is safe for most patients," said Jeffrey L. Carson, MD, the Richard C. Reynolds Professor of Medicine at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and lead author of the JAMA manuscript. "The evidence provided in the synopsis can be used to treat anemic patients in both critical and acute care settings without concern of causing undue harm."

More than 6,000 patients with a mean age of 63 years old were part of the 19 studies included in the systematic review, which showed that death did not increase in patients given a lower threshold blood transfusion. Nor was there a significant difference in major complications such as pneumonia, stroke, infection or pulmonary edema.

"Outcomes Using Lower vs. Higher Hemoglobin Thresholds for Red Blood Cell Transfusion" is the inaugural article in JAMA's Clinical Evidence Synopsis section, which will include summaries of large-scale systematic reviews of similar studies. The briefs provide physicians with access to evidence-based information that can be quickly used to improve patient care.

Dr. Carson developed the blood transfusion guidelines along with specialists in cardiology, pediatrics, critical care medicine, trauma and anesthesia that were issued last March by the AABB (formerly the American Association of Blood Banks). He was lead author on two of the clinical trials included in this Clinical Evidence Synopsis.


Story Source:

The above story is based on materials provided by Robert Wood Johnson Medical School. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carson JL, Carless PA, Hιbert PC. Outcomes Using Lower vs Higher Hemoglobin Thresholds for Red Blood Cell Transfusion. JAMA, 2013; 309 (1): 83-84 DOI: 10.1001/jama.2012.50429

Cite This Page:

Robert Wood Johnson Medical School. "Lower thresholds for blood transfusion found to have no adverse effects on patients' health." ScienceDaily. ScienceDaily, 2 January 2013. <www.sciencedaily.com/releases/2013/01/130102161113.htm>.
Robert Wood Johnson Medical School. (2013, January 2). Lower thresholds for blood transfusion found to have no adverse effects on patients' health. ScienceDaily. Retrieved November 21, 2014 from www.sciencedaily.com/releases/2013/01/130102161113.htm
Robert Wood Johnson Medical School. "Lower thresholds for blood transfusion found to have no adverse effects on patients' health." ScienceDaily. www.sciencedaily.com/releases/2013/01/130102161113.htm (accessed November 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) — Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com
Ebola: Life Without School in Guinea

Ebola: Life Without School in Guinea

AFP (Nov. 21, 2014) — Following the closure of schools and universities in Guinea because of the Ebola virus, students look for temporary work or gather in makeshift classrooms to catch up on their syllabus. Duration: 02:14 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins