Featured Research

from universities, journals, and other organizations

Genes and obesity: Fast food isn't only culprit in expanding waistlines -- DNA is also to blame

Date:
January 8, 2013
Source:
University of California, Los Angeles (UCLA), Health Sciences
Summary:
Researchers say it's not just what you eat that makes those pants tighter -- it's also genetics. In a new study, scientists discovered that body-fat responses to a typical fast-food diet are determined in large part by genetic factors, and they have identified several genes they say may control those responses.

Researchers at UCLA say it's not just what you eat that makes those pants tighter — it's also genetics. In a new study, scientists discovered that body-fat responses to a typical fast-food diet are determined in large part by genetic factors, and they have identified several genes they say may control those responses.

Related Articles


The study is the first of its kind to detail metabolic responses to a high-fat, high-sugar diet in a large and diverse mouse population under defined environmental conditions, modeling closely what is likely to occur in human populations. The researchers found that the amount of food consumed contributed only modestly to the degree of obesity.

The findings are published Jan. 8 in the online edition of the journal Cell Metabolism and will appear Jan. 9 in the print version.

"Our research demonstrates that body-fat responses to high-fat, high-sugar diets have a very strong genetic component, and we have identified several genetic factors potentially regulating these responses," said first author Dr. Brian Parks, a postdoctoral researcher at the David Geffen School of Medicine at UCLA. "We found that obesity has similar genetic signatures in mice and humans, indicating the mice are a highly relevant model system to study obesity. Overall, our work has broad implications concerning the genetic nature of obesity and weight gain."

The dramatic increase in obesity over the past few decades has been tightly associated with an increase in obesity-related conditions such as type 2 diabetes, heart disease and cancer. And while high-calorie diets containing high levels of fat and sugar, along with sedentary lifestyles, have been considered the most significant environmental factors contributing to this epidemic, the new UCLA research demonstrates that body-fat responses to food are strongly inherited and linked to our DNA.

During the two-year study, researchers measured obesity traits, adipose (fat) tissue, global gene expression and intestinal flora (normal intestinal bacteria) in response to a high-fat, high-sugar diet in more than 100 inbred strains of mice. They identified 11 genome-wide "regions" associated with obesity and fat gain due to high-fat, high-sugar intake. Several identified regions overlap with genes identified in human studies.

For the study, the mice were placed on a normal diet for the first eight weeks of life and were subsequently switched to a high-fat, high-sugar diet for eight weeks.

"We measured the change in fat dynamically, at five different points following a high-fat, high-sugar feeding, providing strong evidence for a genetically controlled body-fat set-point," Parks said. "Our use of inbred mice strains also enabled detailed analysis of the relationship between obesity traits, gene expression, intestinal flora and diet."

Dietary responses, as assessed by the body-fat percentage increase during high-fat, high-sugar feeding, varied widely among the strains, with increases in body-fat percentage ranging from 0 to more than 600 percent in the various strains of mice. Most strains responded during the first four weeks of the high-fat, high-sugar feeding and did not accumulate additional fat during the remainder of the study. This suggests an upper body-fat set-point whereby continued gain in body fat is resisted by genetic mechanisms, the researchers said.

Additionally, "We observed high heritability of about 80 percent for body-fat percentage across the study timeline," said principal investigator Dr. Jake Lusis, a professor of medicine and human genetics and of microbiology, immunology and molecular genetics at the Geffen School of Medicine. "Changes in body-fat percentage after high-fat, high-sugar feeding were also highly heritable, suggesting that dietary responses are strongly controlled by genetics."

The results are consistent with the inheritance of body mass index (BMI) and obesity in humans and emphasize the importance of genetics in controlling obesity, the study authors said.

The researchers note that overconsumption of high-calorie, high-sugar food is an important factor contributing to the obesity epidemic but stress that food consumption is only one of many environmental factors that affect obesity.

"Our results emphasize the importance of gene-by-environment interactions, with important implications for an understanding of the overall genetic architecture of obesity," Lusis said. "In particular, it will be of interest to examine behavioral and neurological differences among the strains as they relate to obesity traits."

The researchers noted that mice strains with extremely fast and extremely slow metabolisms must be further studied to understand the effect of energy expenditure on body-fat percentage and the likelihood of obesity.

"Our future studies will investigate the development of metabolic syndrome and diabetes after high-fat, high-sugar feeding," Parks said. "We will also begin to focus on specific, identified genetic factors and their role in dietary interactions and obesity."

The researchers conclude that, based on their data, there appears to be a strong link between DNA and the amount of fat gained when a high-calorie, high-sugar diet is consumed.

The study was funded by the National Institutes of Health (grant HL028481) and a Howard Hughes Medical Institute Early Career Scientist award. Additional funders are listed in the manuscript.

Additional authors include Elizabeth Nam, Elin Org, Emrah Kostem, Frode Norheim, Simon T. Hui, Calvin Pan, Mete Civelek, Christoph D. Rau, Brian J. Bennett, Margarete Mehrabian, Luke K. Ursell, Aiqing He, Lawrence W. Castellani, Bradley Zinker, Mark Kirby, Thomas A. Drake, Christian A. Drevon, Rob Knight, Peter Gargalovic, Todd Kirchgessner and Eleazar Eskin.


Story Source:

The above story is based on materials provided by University of California, Los Angeles (UCLA), Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Brian W. Parks, Elizabeth Nam, Elin Org, Emrah Kostem, Frode Norheim, Simon T. Hui, Calvin Pan, Mete Civelek, Christoph D. Rau, Brian J. Bennett, Margarete Mehrabian, Luke K. Ursell, Aiqing He, Lawrence W. Castellani, Bradley Zinker, Mark Kirby, Thomas A. Drake, Christian A. Drevon, Rob Knight, Peter Gargalovic, Todd Kirchgessner, Eleazar Eskin, Aldons J. Lusis. Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice. Cell Metabolism, 2013; 17 (1): 141-152 DOI: 10.1016/j.cmet.2012.12.007

Cite This Page:

University of California, Los Angeles (UCLA), Health Sciences. "Genes and obesity: Fast food isn't only culprit in expanding waistlines -- DNA is also to blame." ScienceDaily. ScienceDaily, 8 January 2013. <www.sciencedaily.com/releases/2013/01/130108122436.htm>.
University of California, Los Angeles (UCLA), Health Sciences. (2013, January 8). Genes and obesity: Fast food isn't only culprit in expanding waistlines -- DNA is also to blame. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/01/130108122436.htm
University of California, Los Angeles (UCLA), Health Sciences. "Genes and obesity: Fast food isn't only culprit in expanding waistlines -- DNA is also to blame." ScienceDaily. www.sciencedaily.com/releases/2013/01/130108122436.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins