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New protein to treat damaged bones uncovered

Date:
January 9, 2013
Source:
UNIST(Ulsan National Institute of Science and Technology)
Summary:
Researchers believe that the 'DJ-1 protein' can be used to promote the formation of new bone tissue in patients suffering from osteoporosis by improving communication between bone making cells (osteoblasts) and blood vessel (endothelial) cells.
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Osteoblasts actively synthesizing new bone.
Credit: Robert M. Hunt / CC 3.0

Korean researchers believe that the 'DJ-1 protein' can be used to promote the formation of new bone tissue in patients suffering from osteoporosis by improving communication between bone making cells (osteoblasts) and blood vessel (endothelial) cells. The research was published in Nature Communications.

Professor Pann-Gill Suh and Dr. Jung-Min Kim at the School of Nano-Bioscience and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST) identified DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells by screening molecules secreted from as yet undifferentiated human skeletal cells. These skeletal cells, also known as mesenchymal stem cells, have the ability to develop into fully fledged bone cells (osteoblasts).

The researchers showed that DJ-1 stimulates the differentiation of the yet undifferentiated skeletal cells into bone cells by activating fibroblasts, cells which in turn ensure connective tissue growth. Working with rodents, they were able to uncover previously undefined extracellular roles of DJ-1, to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration.


Story Source:

The above post is reprinted from materials provided by UNIST(Ulsan National Institute of Science and Technology). Note: Materials may be edited for content and length.


Journal Reference:

  1. Jung-Min Kim, Hong-In Shin, Sun-Shin Cha, Chang Sup Lee, Bok Sil Hong, Seyoung Lim, Hyun-Jun Jang, Jaeyoon Kim, Yong Ryoul Yang, Yun-Hee Kim, Sanguk Yun, Girdhari Rijal, Whaseon Lee-Kwon, Jeong Kon Seo, Yong Song Gho, Sung Ho Ryu, Eun-Mi Hur, Pann-Ghill Suh. DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. Nature Communications, 2012; 3: 1296 DOI: 10.1038/ncomms2313

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UNIST(Ulsan National Institute of Science and Technology). "New protein to treat damaged bones uncovered." ScienceDaily. ScienceDaily, 9 January 2013. <www.sciencedaily.com/releases/2013/01/130109215312.htm>.
UNIST(Ulsan National Institute of Science and Technology). (2013, January 9). New protein to treat damaged bones uncovered. ScienceDaily. Retrieved September 4, 2015 from www.sciencedaily.com/releases/2013/01/130109215312.htm
UNIST(Ulsan National Institute of Science and Technology). "New protein to treat damaged bones uncovered." ScienceDaily. www.sciencedaily.com/releases/2013/01/130109215312.htm (accessed September 4, 2015).

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