Featured Research

from universities, journals, and other organizations

New protein to treat damaged bones uncovered

Date:
January 9, 2013
Source:
UNIST(Ulsan National Institute of Science and Technology)
Summary:
Researchers believe that the 'DJ-1 protein' can be used to promote the formation of new bone tissue in patients suffering from osteoporosis by improving communication between bone making cells (osteoblasts) and blood vessel (endothelial) cells.

Osteoblasts actively synthesizing new bone.
Credit: Robert M. Hunt / CC 3.0

Korean researchers believe that the 'DJ-1 protein' can be used to promote the formation of new bone tissue in patients suffering from osteoporosis by improving communication between bone making cells (osteoblasts) and blood vessel (endothelial) cells. The research was published in Nature Communications.

Professor Pann-Gill Suh and Dr. Jung-Min Kim at the School of Nano-Bioscience and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST) identified DJ-1 as a novel mediator of the cross-talk between osteoblasts and endothelial cells by screening molecules secreted from as yet undifferentiated human skeletal cells. These skeletal cells, also known as mesenchymal stem cells, have the ability to develop into fully fledged bone cells (osteoblasts).

The researchers showed that DJ-1 stimulates the differentiation of the yet undifferentiated skeletal cells into bone cells by activating fibroblasts, cells which in turn ensure connective tissue growth. Working with rodents, they were able to uncover previously undefined extracellular roles of DJ-1, to promote angiogenesis and osteogenesis, suggesting DJ-1 may have therapeutic potential to stimulate bone regeneration.


Story Source:

The above story is based on materials provided by UNIST(Ulsan National Institute of Science and Technology). Note: Materials may be edited for content and length.


Journal Reference:

  1. Jung-Min Kim, Hong-In Shin, Sun-Shin Cha, Chang Sup Lee, Bok Sil Hong, Seyoung Lim, Hyun-Jun Jang, Jaeyoon Kim, Yong Ryoul Yang, Yun-Hee Kim, Sanguk Yun, Girdhari Rijal, Whaseon Lee-Kwon, Jeong Kon Seo, Yong Song Gho, Sung Ho Ryu, Eun-Mi Hur, Pann-Ghill Suh. DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling. Nature Communications, 2012; 3: 1296 DOI: 10.1038/ncomms2313

Cite This Page:

UNIST(Ulsan National Institute of Science and Technology). "New protein to treat damaged bones uncovered." ScienceDaily. ScienceDaily, 9 January 2013. <www.sciencedaily.com/releases/2013/01/130109215312.htm>.
UNIST(Ulsan National Institute of Science and Technology). (2013, January 9). New protein to treat damaged bones uncovered. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2013/01/130109215312.htm
UNIST(Ulsan National Institute of Science and Technology). "New protein to treat damaged bones uncovered." ScienceDaily. www.sciencedaily.com/releases/2013/01/130109215312.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins