Featured Research

from universities, journals, and other organizations

Injecting botox into stomach does not promote weight loss

Date:
January 28, 2013
Source:
American Gastroenterological Association
Summary:
Despite conflicting data in support of the practice, some overweight Americans looking for an easy fix have turned to gastric botox injections to help them lose weight. Medical researchers have published a definitive study finding that Botox doesn't promote weight loss.

Sixteen weeks after the injections, mean body weights were reduced by 2.2, 0.2, 2.3, and 3.0 kg in these groups, respectively—not a statistically significant difference.
Credit: Image courtesy of American Gastroenterological Association

Gastric injections of botulinum toxin A (BTA) can delay gastric emptying but do not make obese individuals feel more full, alter their eating behaviors, or cause them to lose weight, according to the February issue of Clinical Gastroenterology and Hepatology.

In attempts to help people lose weight, researchers have tested ways to slow gastric emptying (movement of food from the stomach to the small intestine) and increase satiation (feeling full). Gastric injections of BTA have been reported to delay gastric emptying, increase satiation, and reduce body weight, but with inconsistent results.

Botulinum toxin -- a protein and neurotoxin produced by the bacterium Clostridium botulinum -- reduces muscle activity by blocking the release of acetylcholine from neurons.

Mark Topazian et al. compared the effects of injecting different doses of BTA into the stomachs of 60 individuals with mild-to-moderate obesity.

Study participants were each given 1 injection of BTA (100, 300, or 500 U), or placebo, in the gastric antral muscularis propria, guided by endoscopic ultrasound. Gastric emptying of solids was measured by scintigraphy. Topazian et al. also measured participants' body weights every 2 weeks, along with satiation (based on maximum tolerated volume in a caloric liquid drink test), calorie intake (based on a questionnaire), gastrointestinal symptoms, and psychological aspects of eating.

Two weeks after the injections, the mean half-time for gastric emptying of solids increased by 0.8, 14, 24, and 14 minutes among subjects given placebo, 100, 300, or 500 U BTA, respectively.

Sixteen weeks after the injections, mean body weights were reduced by 2.2, 0.2, 2.3, and 3.0 kg in these groups, respectively -- not a statistically significant difference.

Nor were there significant differences among groups in satiation volume, caloric intake, gastrointestinal symptoms, or psychological aspects of eating among groups.

So, although stomach injection of BTA slows gastric emptying, it does not increase the feeling of fullness or lead to loss of body weight. The authors say is unlikely that higher doses of BTA than those tested would induce additional delays in gastric emptying or weight loss.

Previous studies have associated gastrointestinal symptoms with eating behaviors. Topazian et al. did observe that a higher maximum tolerated volume, a physiological measure of satiation, correlated with less control over eating. They propose that educating obese patients about physiological differences in stomach volume might help them improve their ability to control how much they eat.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark Topazian, Michael Camilleri, Felicity T. Enders, Jonathan E. Clain, Ferga C. Gleeson, Michael J. Levy, Elizabeth Rajan, Vandana Nehra, Ross A. Dierkhising, Maria L. Collazo–Clavell, Nicholas J. Talley, Matthew M. Clark. Gastric Antral Injections of Botulinum Toxin Delay Gastric Emptying but Do Not Reduce Body Weight. Clinical Gastroenterology and Hepatology, 2013; 11 (2): 145 DOI: 10.1016/j.cgh.2012.09.029

Cite This Page:

American Gastroenterological Association. "Injecting botox into stomach does not promote weight loss." ScienceDaily. ScienceDaily, 28 January 2013. <www.sciencedaily.com/releases/2013/01/130128163405.htm>.
American Gastroenterological Association. (2013, January 28). Injecting botox into stomach does not promote weight loss. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2013/01/130128163405.htm
American Gastroenterological Association. "Injecting botox into stomach does not promote weight loss." ScienceDaily. www.sciencedaily.com/releases/2013/01/130128163405.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins