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Injecting botox into stomach does not promote weight loss

Date:
January 28, 2013
Source:
American Gastroenterological Association
Summary:
Despite conflicting data in support of the practice, some overweight Americans looking for an easy fix have turned to gastric botox injections to help them lose weight. Medical researchers have published a definitive study finding that Botox doesn't promote weight loss.

Sixteen weeks after the injections, mean body weights were reduced by 2.2, 0.2, 2.3, and 3.0 kg in these groups, respectively—not a statistically significant difference.
Credit: Image courtesy of American Gastroenterological Association

Gastric injections of botulinum toxin A (BTA) can delay gastric emptying but do not make obese individuals feel more full, alter their eating behaviors, or cause them to lose weight, according to the February issue of Clinical Gastroenterology and Hepatology.

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In attempts to help people lose weight, researchers have tested ways to slow gastric emptying (movement of food from the stomach to the small intestine) and increase satiation (feeling full). Gastric injections of BTA have been reported to delay gastric emptying, increase satiation, and reduce body weight, but with inconsistent results.

Botulinum toxin -- a protein and neurotoxin produced by the bacterium Clostridium botulinum -- reduces muscle activity by blocking the release of acetylcholine from neurons.

Mark Topazian et al. compared the effects of injecting different doses of BTA into the stomachs of 60 individuals with mild-to-moderate obesity.

Study participants were each given 1 injection of BTA (100, 300, or 500 U), or placebo, in the gastric antral muscularis propria, guided by endoscopic ultrasound. Gastric emptying of solids was measured by scintigraphy. Topazian et al. also measured participants' body weights every 2 weeks, along with satiation (based on maximum tolerated volume in a caloric liquid drink test), calorie intake (based on a questionnaire), gastrointestinal symptoms, and psychological aspects of eating.

Two weeks after the injections, the mean half-time for gastric emptying of solids increased by 0.8, 14, 24, and 14 minutes among subjects given placebo, 100, 300, or 500 U BTA, respectively.

Sixteen weeks after the injections, mean body weights were reduced by 2.2, 0.2, 2.3, and 3.0 kg in these groups, respectively -- not a statistically significant difference.

Nor were there significant differences among groups in satiation volume, caloric intake, gastrointestinal symptoms, or psychological aspects of eating among groups.

So, although stomach injection of BTA slows gastric emptying, it does not increase the feeling of fullness or lead to loss of body weight. The authors say is unlikely that higher doses of BTA than those tested would induce additional delays in gastric emptying or weight loss.

Previous studies have associated gastrointestinal symptoms with eating behaviors. Topazian et al. did observe that a higher maximum tolerated volume, a physiological measure of satiation, correlated with less control over eating. They propose that educating obese patients about physiological differences in stomach volume might help them improve their ability to control how much they eat.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark Topazian, Michael Camilleri, Felicity T. Enders, Jonathan E. Clain, Ferga C. Gleeson, Michael J. Levy, Elizabeth Rajan, Vandana Nehra, Ross A. Dierkhising, Maria L. Collazo–Clavell, Nicholas J. Talley, Matthew M. Clark. Gastric Antral Injections of Botulinum Toxin Delay Gastric Emptying but Do Not Reduce Body Weight. Clinical Gastroenterology and Hepatology, 2013; 11 (2): 145 DOI: 10.1016/j.cgh.2012.09.029

Cite This Page:

American Gastroenterological Association. "Injecting botox into stomach does not promote weight loss." ScienceDaily. ScienceDaily, 28 January 2013. <www.sciencedaily.com/releases/2013/01/130128163405.htm>.
American Gastroenterological Association. (2013, January 28). Injecting botox into stomach does not promote weight loss. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2013/01/130128163405.htm
American Gastroenterological Association. "Injecting botox into stomach does not promote weight loss." ScienceDaily. www.sciencedaily.com/releases/2013/01/130128163405.htm (accessed December 19, 2014).

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