Featured Research

from universities, journals, and other organizations

Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury

Date:
March 4, 2013
Source:
University of Central Florida
Summary:
Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a new study.

Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.

Related Articles


Alvaro Estevez, an associate professor at the University of Central Florida's College of Medicine, led the multi-university team that made the discovery, which could eventually help scientists develop new therapies to combat a host of conditions from stroke to Lou Gehrig's disease.

Researchers have long known that oxidative stress damages cells and results in neurodegeneration, inflammation and aging. It was commonly believed that oxidation made a "crude," demolition-like attack on cells, causing them to crumble like a building in an earthquake, Estevez said. However, the latest findings show that oxidation results in a much more targeted attack to specific parts of the cell. Oxidative stress damages a specific "chaperone" cell protein called Hsp90. It plays a role in up to 200 different cell functions. But when a form of oxidative stress called tyrosine nitration modifies that protein, it turns into the cell "executioner" shutting it down.

"The concept that a protein that is normally protective and indispensable for cell survival and growth can turn into a killing machine, and just because of one specific oxidative modification, is amazing," said Maria C. Franco, a postdoctoral associate at UCF's Burnett School of Biomedical Sciences. She co-wrote the study. "Considering that this modified protein is present in a vast number of pathologies, it gives us hopes on finding new therapeutics approaches for several different diseases."

For example, researchers could devise a drug that stroke patients could take at the onset of their symptoms to prevent more healthy cells from dying, thus limiting the damage of the stroke. Because oxidation is linked to inflammation, researchers believe tyrosine nitration could also be related to other health problems including heart disease, cancer, aging and chronic pain.

"These are very exciting results and could begin a major shift in medicine," said Joseph Beckman, from Oregon State University Environmental Health Sciences Center, a collaborator on the study. "Preventing this process of tyrosine nitration may protect against a wide range of degenerative diseases."

"Most people think of things like heart disease, cancer, aging, liver disease, even the damage from spinal injury as completely different medical issues," Beckman said. "To the extent they can often be traced back to inflammatory processes that are caused by oxidative attack and cellular damage, they can be more similar than different. It could be possible to develop therapies with value against many seemingly different health problems."

Other contributors to the study include: Nicklaus A. Sparrow from UCF, Yaozu Ye from the University of Alabama at Birmingham, Christian A. Refakis, Jessica L. Feldman and Audrey L. Stokes from Franklin and Marshall College, Manuela Basso and Thong C. Ma from the Burke Medical Research Institute, Raquel M. Melero Fernández de Mera from Universidad de Castilla-La Mancha, Noel Y. Calingasan, Mahmoud Kiaei and M. Flint Beal from Weill Cornell Medical College, Timothy W. Rhoads, and Ryan Mehl from Oregon State University and Martin Grumet from Rutgers State University of New Jersey.

The National Institutes of Health, the Burke Medical Research Institute, the ALS Association and other agencies financially supported this study.

Estevez joined the UCF College of Medicine in 2010. Previously he worked as a postdoctoral investigator at the University of Alabama at Birmingham and then as an assistant professor. In 2005 Estevez joined the Burke Cornell Medical Research Institute a part of the Weill Cornell Medical College in New York. Estevez has several degrees including a doctorate in philosophy, biology and cell biology from the Instituto Clemente Estable in Montevideo Uruguay.


Story Source:

The above story is based on materials provided by University of Central Florida. The original article was written by Wendy Sarubbi. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maria Clara Franco, Yaozu Ye, Christian A. Refakis, Jessica L. Feldman, Audrey L. Stokes, Manuela Basso, Raquel M. Melero Fernández de Mera, Nicklaus A. Sparrow, Noel Y. Calingasan, Mahmoud Kiaei, Timothy W. Rhoads, Thong C. Ma, Martin Grumet, Stephen Barnes, M. Flint Beal, Joseph S. Beckman, Ryan Mehl, and Alvaro G. Estévez. Nitration of Hsp90 induces cell death. PNAS, 2013 DOI: 10.1073/pnas.1215177110

Cite This Page:

University of Central Florida. "Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury." ScienceDaily. ScienceDaily, 4 March 2013. <www.sciencedaily.com/releases/2013/03/130304151850.htm>.
University of Central Florida. (2013, March 4). Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/03/130304151850.htm
University of Central Florida. "Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury." ScienceDaily. www.sciencedaily.com/releases/2013/03/130304151850.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) — Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) — Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) — A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) — Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

More Coverage


Discovery Opens Door to New Drug Options for Serious Diseases

Mar. 4, 2013 — Researchers have discovered how oxidative stress can turn to the dark side a cellular protein that's usually benign, and make it become a powerful, unwanted accomplice in neuronal death. This ... read more

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins