Featured Research

from universities, journals, and other organizations

Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury

Date:
March 4, 2013
Source:
University of Central Florida
Summary:
Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a new study.

Oxidative stress turns a protein that normally protects healthy cells into their executioner, according to a study released today in the Proceedings of the National Academy of Sciences journal.

Alvaro Estevez, an associate professor at the University of Central Florida's College of Medicine, led the multi-university team that made the discovery, which could eventually help scientists develop new therapies to combat a host of conditions from stroke to Lou Gehrig's disease.

Researchers have long known that oxidative stress damages cells and results in neurodegeneration, inflammation and aging. It was commonly believed that oxidation made a "crude," demolition-like attack on cells, causing them to crumble like a building in an earthquake, Estevez said. However, the latest findings show that oxidation results in a much more targeted attack to specific parts of the cell. Oxidative stress damages a specific "chaperone" cell protein called Hsp90. It plays a role in up to 200 different cell functions. But when a form of oxidative stress called tyrosine nitration modifies that protein, it turns into the cell "executioner" shutting it down.

"The concept that a protein that is normally protective and indispensable for cell survival and growth can turn into a killing machine, and just because of one specific oxidative modification, is amazing," said Maria C. Franco, a postdoctoral associate at UCF's Burnett School of Biomedical Sciences. She co-wrote the study. "Considering that this modified protein is present in a vast number of pathologies, it gives us hopes on finding new therapeutics approaches for several different diseases."

For example, researchers could devise a drug that stroke patients could take at the onset of their symptoms to prevent more healthy cells from dying, thus limiting the damage of the stroke. Because oxidation is linked to inflammation, researchers believe tyrosine nitration could also be related to other health problems including heart disease, cancer, aging and chronic pain.

"These are very exciting results and could begin a major shift in medicine," said Joseph Beckman, from Oregon State University Environmental Health Sciences Center, a collaborator on the study. "Preventing this process of tyrosine nitration may protect against a wide range of degenerative diseases."

"Most people think of things like heart disease, cancer, aging, liver disease, even the damage from spinal injury as completely different medical issues," Beckman said. "To the extent they can often be traced back to inflammatory processes that are caused by oxidative attack and cellular damage, they can be more similar than different. It could be possible to develop therapies with value against many seemingly different health problems."

Other contributors to the study include: Nicklaus A. Sparrow from UCF, Yaozu Ye from the University of Alabama at Birmingham, Christian A. Refakis, Jessica L. Feldman and Audrey L. Stokes from Franklin and Marshall College, Manuela Basso and Thong C. Ma from the Burke Medical Research Institute, Raquel M. Melero Fernández de Mera from Universidad de Castilla-La Mancha, Noel Y. Calingasan, Mahmoud Kiaei and M. Flint Beal from Weill Cornell Medical College, Timothy W. Rhoads, and Ryan Mehl from Oregon State University and Martin Grumet from Rutgers State University of New Jersey.

The National Institutes of Health, the Burke Medical Research Institute, the ALS Association and other agencies financially supported this study.

Estevez joined the UCF College of Medicine in 2010. Previously he worked as a postdoctoral investigator at the University of Alabama at Birmingham and then as an assistant professor. In 2005 Estevez joined the Burke Cornell Medical Research Institute a part of the Weill Cornell Medical College in New York. Estevez has several degrees including a doctorate in philosophy, biology and cell biology from the Instituto Clemente Estable in Montevideo Uruguay.


Story Source:

The above story is based on materials provided by University of Central Florida. The original article was written by Wendy Sarubbi. Note: Materials may be edited for content and length.


Journal Reference:

  1. Maria Clara Franco, Yaozu Ye, Christian A. Refakis, Jessica L. Feldman, Audrey L. Stokes, Manuela Basso, Raquel M. Melero Fernández de Mera, Nicklaus A. Sparrow, Noel Y. Calingasan, Mahmoud Kiaei, Timothy W. Rhoads, Thong C. Ma, Martin Grumet, Stephen Barnes, M. Flint Beal, Joseph S. Beckman, Ryan Mehl, and Alvaro G. Estévez. Nitration of Hsp90 induces cell death. PNAS, 2013 DOI: 10.1073/pnas.1215177110

Cite This Page:

University of Central Florida. "Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury." ScienceDaily. ScienceDaily, 4 March 2013. <www.sciencedaily.com/releases/2013/03/130304151850.htm>.
University of Central Florida. (2013, March 4). Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury. ScienceDaily. Retrieved April 24, 2014 from www.sciencedaily.com/releases/2013/03/130304151850.htm
University of Central Florida. "Discovery of 'executioner' protein opens door to new options for stroke ALS, spinal cord injury." ScienceDaily. www.sciencedaily.com/releases/2013/03/130304151850.htm (accessed April 24, 2014).

Share This



More Health & Medicine News

Thursday, April 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

More Coverage


Discovery Opens Door to New Drug Options for Serious Diseases

Mar. 4, 2013 — Researchers have discovered how oxidative stress can turn to the dark side a cellular protein that's usually benign, and make it become a powerful, unwanted accomplice in neuronal death. This ... read more
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins