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Novel 'ultra-deep de novo' assembly solution for heterozygous genomes

Date:
March 11, 2013
Source:
BGI Shenzhen
Summary:
Scientists have developed a novel assembly solution for facilitating heterozygous genomes research.

BGI Tech Solutions Co., Ltd., also referred to as "BGI Tech," introduced today its novel assembly solution for facilitating heterozygous genomes research. This marks another technological breakthrough for BGI in heterozygous genome assembly after the completed genome sequencing of oyster, diamondback moth and pear.

The availability of a reference genome for a species is the cornerstone for the in-depth understanding of its biological secrets and commercial values. However, a major obstacle that prevents scientists to easily crack the genome of a heterozygous species is the cost-intensive and time-consuming process through traditional assembly approaches.

To overcome the technical difficulties, researchers from BGI Tech developed a novel assembly solution, Ultra-Deep de novo, based upon high-throughput sequencing technology. The new solution adopts BGI's latest assembly software, SOAPdenovo2, and heterozygous sequence processing algorithm. After processing the genomic data produced by ultra-deep sequencing (>200X), the heterozygous regions within the genome can be entirely reserved and classified, with high quality and efficiency.

"Ultra-Deep de novo can serve as a robust tool for researchers to efficiently decode heterozygous genomes." said, Junyi Wang, Senior Vice President of BGI Tech, "BGI has completed the genome sequencing of more than 570 species to date. Some of the species have not been studied because of the challenges posed by high heterozygosis. We believe that this new solution will be a powerful tool for researchers to crack more heterozygous genomes, and boost the further development of agriculture and human health."


Story Source:

The above story is based on materials provided by BGI Shenzhen. Note: Materials may be edited for content and length.


Cite This Page:

BGI Shenzhen. "Novel 'ultra-deep de novo' assembly solution for heterozygous genomes." ScienceDaily. ScienceDaily, 11 March 2013. <www.sciencedaily.com/releases/2013/03/130311101746.htm>.
BGI Shenzhen. (2013, March 11). Novel 'ultra-deep de novo' assembly solution for heterozygous genomes. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2013/03/130311101746.htm
BGI Shenzhen. "Novel 'ultra-deep de novo' assembly solution for heterozygous genomes." ScienceDaily. www.sciencedaily.com/releases/2013/03/130311101746.htm (accessed August 21, 2014).

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