Featured Research

from universities, journals, and other organizations

Differences in bone healing in young vs. old mice may hold answers to better bone healing for seniors

Date:
March 21, 2013
Source:
Perelman School of Medicine at the University of Pennsylvania
Summary:
By studying the underlying differences in gene expression during healing after a bone break in young versus aged mice, scientists aim to find specific pathways of fracture healing in humans.

By studying the underlying differences in gene expression during healing after a bone break in young versus aged mice, Jaimo Ahn, MD, PhD, assistant professor of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania, and his colleagues aim to find specific pathways of fracture healing in humans. The team of researchers will present their findings in a poster presentation beginning Tuesday, March 19, 2013 at the 2013 American Academy of Orthopedic Surgeons annual meeting in Chicago.

Problems with healing after bone fractures in elderly patients can be attributed, in part, to the compromised function of certain stem cells, called MSCs, that participate in the mending of the fracture. MSCs (Mesenchymal stem cells), can differentiate into a variety of cell types: cartilage, fat and -- most notably in fractures -- bone cells.

An important pathway -- called Notch, for the name of the receptor that is critical in relaying the "signal" -- has been identified as a critical event in the healing of non-skeletal tissues in an age-dependent manner. In the new study, the Penn team suspected that Notch would play a vital role in healing aged broken bones.

The team characterized fracture healing as a function of age and time post fracture in laboratory mice. Five-month-old laboratory mice are reproductively and skeletally mature. At 25-months-old, mice of the same strain are considered "geriatric." The researchers looked for progression of tissue and healing and the expression of Notch pathway genes including the ligands (small molecules that bind Notch to spur it into action), as well as Notch receptors and their down-stream effects. They examined both the healing fracture itself as well as the MSCs from the two age groups.

The team found that young mice produce a more robust healing response (timing, quantity and quality) than geriatric mice which persisted throughout healing. Interestingly, base line levels of Notch signaling are reduced in MSCs from geriatric mice. However, MSCs from young and old mice are both able to be stimulated by Jagged1 (one of the main ligands of Notch).

"The Notch signaling pathway's importance in skeletogenesis combined with our data showing reduced baseline Notch activity in geriatric MSCs and the ability of the MSCs to respond to Jagged1 provides a rational basis for delivery of Jagged1 as a potential therapeutic option for aged fractures" says Dr Ahn.

Importantly, this model provides a validated system for further study of the age-dependent differences in fracture healing -- and to test alterations that will enhance that healing for years to come.

Additional Penn authors include Kurt Hankenson, DVM, PhD, Nicole Belkin, MD, Luke Lopas, Lorraine Mutyaba, and Lee McDaniel.


Story Source:

The above story is based on materials provided by Perelman School of Medicine at the University of Pennsylvania. Note: Materials may be edited for content and length.


Cite This Page:

Perelman School of Medicine at the University of Pennsylvania. "Differences in bone healing in young vs. old mice may hold answers to better bone healing for seniors." ScienceDaily. ScienceDaily, 21 March 2013. <www.sciencedaily.com/releases/2013/03/130321131927.htm>.
Perelman School of Medicine at the University of Pennsylvania. (2013, March 21). Differences in bone healing in young vs. old mice may hold answers to better bone healing for seniors. ScienceDaily. Retrieved August 2, 2014 from www.sciencedaily.com/releases/2013/03/130321131927.htm
Perelman School of Medicine at the University of Pennsylvania. "Differences in bone healing in young vs. old mice may hold answers to better bone healing for seniors." ScienceDaily. www.sciencedaily.com/releases/2013/03/130321131927.htm (accessed August 2, 2014).

Share This




More Health & Medicine News

Saturday, August 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Quintuplets Head Home

Texas Quintuplets Head Home

Reuters - US Online Video (Aug. 1, 2014) After four months in the hospital, the first quintuplets to be born at Baylor University Medical Center head home. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Patient Coming to U.S. for Treatment

Ebola Patient Coming to U.S. for Treatment

Reuters - US Online Video (Aug. 1, 2014) A U.S. aid worker infected with Ebola while working in West Africa will be treated in a high security ward at Emory University in Atlanta. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Ebola Vaccine Might Be Coming, But Where's It Been?

Ebola Vaccine Might Be Coming, But Where's It Been?

Newsy (Aug. 1, 2014) Health officials are working to fast-track a vaccine — the West-African Ebola outbreak has killed more than 700. But why didn't we already have one? Video provided by Newsy
Powered by NewsLook.com
Study Links Certain Birth Control Pills To Breast Cancer

Study Links Certain Birth Control Pills To Breast Cancer

Newsy (Aug. 1, 2014) Previous studies have made the link between birth control and breast cancer, but the latest makes the link to high-estrogen oral contraceptives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins