Featured Research

from universities, journals, and other organizations

Cervical cancer: DNA-based test more accurate than repeat smear ('Pap')

Date:
March 28, 2013
Source:
Wiley
Summary:
In women who have a potentially or mildly abnormal cervical smear, using a DNA-based test can identify those at higher risk of having precursors of cervical cancer, according to a new Cochrane systematic review. The authors found that the DNA-based test identified patients in possible need of treatment more accurately than a repeat smear test

In women who have a potentially or mildly abnormal cervical smear, using a DNA-based test can identify those at higher risk of having precursors of cervical cancer, according to a new Cochrane systematic review. The authors found that the DNA-based test identified patients in possible need of treatment more accurately than a repeat smear test.

Related Articles


Cervical smear ("Pap") tests are carried out to identify women who might be at high risk of developing cervical cancer. Cells collected in the smear test are examined under the microscope. If abnormalities are seen, a patient may be asked to undergo further tests to determine whether the abnormalities are serious and whether treatment of pre-cancer is required to prevent cancer developing. Sometimes the cells examined from the smear are not clearly normal or abnormal (referred to with the acronym 'ASCUS' or 'borderline nuclear changes'), whereas other types of cells identified are only mildly abnormal (referred to as 'LSIL' or mild dyskaryosis). The main cause of cervical cancer is the human papillomavirus, although only a small number of women who carry the virus go on to develop cervical cancer. The Hybrid Capture 2 (HC2) assay is a DNA-based method that tests for DNA from those strains of the virus that are higher risk for cervical cancer.

The authors compared the HC2 test with a repeat conventional smear test as a way of prioritising possible cases that have cervical pre- cancer. They reviewed 39 studies involving a total of 13,196 women. Compared to a repeat smear, the HC2 test more accurately identified women with pre- cancer.

"Based on these findings, the HC2 test can be recommended as a way of triaging women with an ASCUS smear," said lead researcher, Marc Arbyn of the Unit of Cancer Epidemiology at the Scientific Institute of Public Health in Brussels, Belgium.

However, the HC2 test over-called the risk of pre-cancer in women with LSIL abnormalities and the researchers conclude that more specific tests are needed to triage women with LSIL. "The use of the HC2 test in women with LSIL abnormalities in their smear test results should be carefully considered," said Arbyn. "It may be more accurate in older women with these abnormalities, but it is important to take into account the local cost of further, more invasive tests and to avoid unnecessary referrals and anxiety."


Story Source:

The above story is based on materials provided by Wiley. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marc Arbyn, Jolien Roelens, Cindy Simoens, Frank Buntinx, Evangelos Paraskevaidis, Pierre PL Martin-Hirsch, Walter J Prendiville. Human papillomavirus testing versus repeat cytology for triage of minor cytological cervical lesions. Cochrane Database of Systematic Reviews, 2013; DOI: 10.1002/14651858.CD008054.pub2

Cite This Page:

Wiley. "Cervical cancer: DNA-based test more accurate than repeat smear ('Pap')." ScienceDaily. ScienceDaily, 28 March 2013. <www.sciencedaily.com/releases/2013/03/130328075832.htm>.
Wiley. (2013, March 28). Cervical cancer: DNA-based test more accurate than repeat smear ('Pap'). ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2013/03/130328075832.htm
Wiley. "Cervical cancer: DNA-based test more accurate than repeat smear ('Pap')." ScienceDaily. www.sciencedaily.com/releases/2013/03/130328075832.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins