Featured Research

from universities, journals, and other organizations

New multiple myeloma treatment guidelines personalize therapy for patients

Date:
April 1, 2013
Source:
Mayo Clinic
Summary:
Researchers have developed new guidelines to treat recently diagnosed multiple myeloma patients who are not participating in clinical trials. The guidelines give physicians practical, easy to follow recommendations for providing initial therapy, stem cell transplant and maintenance therapy.

Researchers at Mayo Clinic Cancer Center have developed new guidelines to treat recently diagnosed multiple myeloma patients who are not participating in clinical trials. The guidelines give physicians practical, easy to follow recommendations for providing initial therapy, stem cell transplant and maintenance therapy. The guidelines are published in the current issue of the journal Mayo Clinic Proceedings and represent a consensus opinion of hematologists at Mayo Clinic Cancer Center sites in Minnesota, Florida and Arizona.

Related Articles


"Multiple myeloma is an incurable blood cancer that affects more than 20,000 people in the U.S. each year," says lead author Joseph Mikhael, M.D. a hematologist at Mayo Clinic in Arizona. "Over the past decade we have made great progress in understanding the disease, developing drug therapies and increasing overall survival. However, as a medical community we haven't done as good a job at optimizing therapy based on a patient's individual risk factors."

Dr. Mikhael says the new guidelines will help patients with low-risk disease avoid the harsh side effects of therapy and will reserve more intense therapy for patients with aggressive disease.

Among the guidelines:

  • A strong recommendation to enroll patients in clinical trials as the first option for therapy or supportive care.
  • Separating patients by risk into three groups to make the most of new drug therapy: high risk, intermediate risk and low risk. Previous guidelines included only two groups: high risk and standard risk.
  • Adding factors to assess the risk the multiple myeloma poses to the patient, including use of gene expression profiling to help identify patients with high-risk disease.
  • Greater emphasis on delaying stem cell transplants to take advantage of improved chemotherapy, resulting in better responses.
  • Maintenance therapy using drugs such as lenalidomide and bortezomib that balance benefit with short- and long-term toxicity.

Co-authors include David Dingli, M.D., Ph.D.; Vivek Roy, M.D.; Craig Reeder, M.D.; Francis Buadi, M.D.; Suzanne Hayman, M.D.; Angela Dispenzieri, M.D.; Rafael Fonseca, M.D.; Taimur Sher, M.D.; Robert Kyle, M.D.; Yi Lin, M.D., Ph.D.; Stephen Russell, M.D., Ph.D.; Shaji Kumar, M.D.; Leif Bergsagel, M.D.; Steven Zeldenrust, M.D., Ph.D.; Nelson Leung, M.D.; Matthew Drake, M.D., Ph.D.; Prashant Kapoor, M.D.; Stephen Ansell, M.D., Ph.D.; Thomas Witzig, M.D.; John Lust, M.D., Ph.D.; Robert Dalton, M.D.; Morie Gertz, M.D.; Keith Stewart, M.B.Ch.B.; Vincent Rajkumar, M.D.; Asher Chanan-Khan, M.D.; and Martha Lacy, M.D., all of Mayo Clinic.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Journal Reference:

  1. Joseph R. Mikhael, David Dingli, Vivek Roy, Craig B. Reeder, Francis K. Buadi, Suzanne R. Hayman, Angela Dispenzieri, Rafael Fonseca, Taimur Sher, Robert A. Kyle, Yi Lin, Stephen J. Russell, Shaji Kumar, P. Leif Bergsagel, Steven R. Zeldenrust, Nelson Leung, Matthew T. Drake, Prashant Kapoor, Stephen M. Ansell, Thomas E. Witzig, John A. Lust, Robert J. Dalton, Morie A. Gertz, Keith Stewart, S. Vincent Rajkumar, Asher Chanan-Khan, Martha Q. Lacy. Management of Newly Diagnosed Symptomatic Multiple Myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines 2013. Mayo Clinic Proceedings, 2013; 88 (4): 360 DOI: 10.1016/j.mayocp.2013.01.019

Cite This Page:

Mayo Clinic. "New multiple myeloma treatment guidelines personalize therapy for patients." ScienceDaily. ScienceDaily, 1 April 2013. <www.sciencedaily.com/releases/2013/04/130401131658.htm>.
Mayo Clinic. (2013, April 1). New multiple myeloma treatment guidelines personalize therapy for patients. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2013/04/130401131658.htm
Mayo Clinic. "New multiple myeloma treatment guidelines personalize therapy for patients." ScienceDaily. www.sciencedaily.com/releases/2013/04/130401131658.htm (accessed October 24, 2014).

Share This



More Health & Medicine News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Ebola Fears Keep Guinea Hospitals Empty

Ebola Fears Keep Guinea Hospitals Empty

AP (Oct. 23, 2014) Fears of Ebola are keeping doctors and patients alike away from hospitals in the West African nation of Guinea. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Despite Rising Death Toll, Many Survive Ebola

Despite Rising Death Toll, Many Survive Ebola

AP (Oct. 23, 2014) The family of a Dallas nurse infected with Ebola in the US says doctors can no longer detect the virus in her. Despite the mounting death toll in West Africa, there are survivors there too. (Oct. 23) Video provided by AP
Powered by NewsLook.com
Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Orthodontist Mom Jennifer Salzer on the Best Time for Braces

Working Mother (Oct. 22, 2014) Is your child ready? Video provided by Working Mother
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins