Featured Research

from universities, journals, and other organizations

Assessing insulin resistance can inform about breast cancer risk

Date:
April 4, 2013
Source:
Sbarro Health Research Organization (SHRO)
Summary:
The link between obesity and cancer seems now well established although the molecular mechanisms underlying this connection are still largely unexplored. Scientists have ow studied the correlation between breast cancer and insulin resistance — an obesity-related condition in which certain cells fail to respond to the glucose-lowering action of the insulin hormone.

In a previous work the authors analyzed a large cohort of breast cancer patients to look whether an association existed between the risk of tumor development and the presence of the metabolic syndrome -- a syndrome that predisposes to cardiovascular and other diseases, which is characterized by abdominal obesity, high levels of triglycerides and low concentrations of HDL cholesterol, increased blood pressure and insulin resistance.

Related Articles


The authors indeed found an higher prevalence of metabolic syndrome among women affected by breast cancer in postmenopause compared to healthy women. In the new study the scientists confirm their previous findings and expand on by zooming in the contribution of insulin resistance.

When tissues become resistant to the action of insulin -- which occurs often in obese people -- a balancing mechanism further increases insulin production leading to a chronic hyperinsulinemia. Such high insulin levels can be detrimental to the body because insulin not only regulates glucose metabolism but has more functions such as stimulating cell proliferation and survival. Therefore the continuous activation of insulin pathways can contribute to cancer development by fuelling cancer cell growth. Consistently, by analyzing a cohort of 410 patients and 565 healthy women, the researchers found that 49% of patients were insulin resistant compared with 34% of controls indicating that insulin resistance can indeed increase the risk of developing breast cancer. Most of the insulin resistant patients were postmenopausal but, interestingly, most of them had fasting plasma glucose and/or fasting plasma levels in the normal range. It was only through the application of the homeostasis model assessment of insulin resistance (HOMA-IR) that the authors were able to identify a subset of patients with a subclinical insulin resistance but an increased cancer risk.

The HOMA-IR method takes into account both fasting plasma glucose and fasting plasma levels and is widely used in epidemiological studies to determine insulin resistance.

Overall these findings, obtained through the collaboration of the National Cancer Institute of Naples "Pascale Foundation," with the Sbarro Institute and the University of Siena, further support the hypothesis that metabolic syndrome, and particularly abdominal fat (waist circumference more than 88cm) and insulin resistance, can be considered risk factors for developing breast cancer after menopause. "Remarkably, HOMA-IR proves to be a promising tool for the identification of subclinical insulin resistance and to inform on breast cancer risk" says the leading author of the study, Immacolata Capasso, M.D. of the National Cancer Institute of Naples "Pascale Foundation," Italy. "Powerful tools for primary prevention are needed to help focusing the efforts on modifiable variables, such as life style habits including food and drink consumption and physical activity, and reduce the tumor burden" says Francesca Pentimalli, PhD, of the Center for Oncology Research of Mercogliano (CROM), Italy and coauthor of the study.


Story Source:

The above story is based on materials provided by Sbarro Health Research Organization (SHRO). Note: Materials may be edited for content and length.


Journal References:

  1. Immacolata Capasso, Emanuela Esposito, Francesca Pentimalli, Maurizio Montella, Anna Crispo, Nicola Maurea, Massimiliano D¿Aiuto, Alfredo Fucito, Maria Grimaldi, Ernesta Cavalcanti, Giuseppe Esposito, Giuseppe Brillante, Sergio Lodato, Tonino Pedicini, Giuseppe D¿Aiuto, Gennaro Ciliberto, Antonio Giordano. Homeostasis model assessment to detect insulin resistance and identify patients at high risk of breast cancer development: national cancer institute of Naples experience. Journal of Experimental & Clinical Cancer Research, 2013; 32 (1): 14 DOI: 10.1186/1756-9966-32-14
  2. Immacolata Capasso, Emanuela Esposito, Francesca Pentimalli, Anna Crispo, Maurizio Montella, Maria Grimaldi, MariaRosaria De Marco, Ernestina Cavalcanti, Massimiliano D’Aiuto, Alfredo Fucito, Giuseppe Frasci, Nicola Maurea, Giuseppe Esposito, Tonino Pedicini, Aldo Vecchione, Giuseppe D’Aiuto, Antonio Giordano. Metabolic syndrome affects breast cancer risk in postmenopausal women: National Cancer Institute of Naples experience. Cancer Biology & Therapy, 2010; 10 (12): 1240 DOI: 10.4161/cbt.10.12.13473

Cite This Page:

Sbarro Health Research Organization (SHRO). "Assessing insulin resistance can inform about breast cancer risk." ScienceDaily. ScienceDaily, 4 April 2013. <www.sciencedaily.com/releases/2013/04/130404135200.htm>.
Sbarro Health Research Organization (SHRO). (2013, April 4). Assessing insulin resistance can inform about breast cancer risk. ScienceDaily. Retrieved February 26, 2015 from www.sciencedaily.com/releases/2013/04/130404135200.htm
Sbarro Health Research Organization (SHRO). "Assessing insulin resistance can inform about breast cancer risk." ScienceDaily. www.sciencedaily.com/releases/2013/04/130404135200.htm (accessed February 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, February 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) — People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) — Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) — A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) — Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins