Featured Research

from universities, journals, and other organizations

Obesity may influence heart function through sex hormones

Date:
April 28, 2013
Source:
European Society of Endocrinology
Summary:
New research suggests that changes in sex hormones as seen in obesity may have possible effects on the heart. The study suggests effects on heart function in healthy men with artificially raised estrogen levels and artificially lowered testosterone levels to mimic an obese state.

New research suggests that changes in sex hormones as seen in obesity may have possible effects on the heart. The study by researchers from Belgium, presented at the European Congress of Endocrinology in Copenhagen, Denmark, suggests effects on heart function in healthy men with artificially raised estrogen levels and artificially lowered testosterone levels to mimic an obese state.

Related Articles


Estradiol, an estrogen, is primarily known as a female hormone but it also circulates at very low levels in men. Testosterone is converted to estradiol by the enzyme aromatase, the activity of which might be increased in obesity leading to raised estradiol and reduced testosterone.

To determine whether obesity might alter heart function via changes in sex hormones, Drs Maarten De Smet and colleagues at Ghent University in Belgium recruited 20 healthy men aged 20-40 and used an aromatase inhibitor and an estrogen patch to artificially alter the hormone levels to mimic sex hormone concentrations in obesity (high estradiol and low testosterone) vs contrast by an aromatase inhibitor (low estradiol, high testosterone). Prof Dr T De Backer, Cardiologist, assessed the heart function before and seven days after the intervention using ultrasonographic imaging with strain analysis, which measures the deformation of the heart between the resting and contracted states.

The men with obesity-related changes in sex hormones exhibited altered heart function. At baseline the global circumferential strain was -17.1% +/-3.9, which decreased significantly to -14% +/-2.5 (p=0.01). The contrasting group did not show any difference.

By artificially altering sex hormones in a small number of healthy men, Drs De Smet and colleagues have shown that an altered sex hormone profile as seen in obesity might be relevant for heart function. Adequately powered clinical trials with sufficient duration may establish the role of sex hormones in the heart function of obese men.

Maarten De Smet, Masters student in Medicine at Ghent University, Belgium, and first author said:

"Obesity is a major contributor to heart disease. By giving an aromatase inhibitor and estrogen to healthy men we mimicked the effect of sex hormones in obesity alone, in isolation from the rest of the obese metabolic state.

"In order to pump blood around the body the heart must fill with blood and then contract, pushing the blood out. We found that after increasing the estrogen levels and decreasing the testosterone levels in men for one week the deformation of the left heart chamber was significantly altered.

"Because the contributing factors to obesity, as well as the underlying biology, are so complicated it's a real challenge to tease apart one single aspect, so we think this study is of particular interest. As these results are from a small number of healthy men over one week, we hope to investigate sex hormone changes and the heart in the obese in the long term."


Story Source:

The above story is based on materials provided by European Society of Endocrinology. Note: Materials may be edited for content and length.


Cite This Page:

European Society of Endocrinology. "Obesity may influence heart function through sex hormones." ScienceDaily. ScienceDaily, 28 April 2013. <www.sciencedaily.com/releases/2013/04/130428144857.htm>.
European Society of Endocrinology. (2013, April 28). Obesity may influence heart function through sex hormones. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2013/04/130428144857.htm
European Society of Endocrinology. "Obesity may influence heart function through sex hormones." ScienceDaily. www.sciencedaily.com/releases/2013/04/130428144857.htm (accessed October 31, 2014).

Share This



More Health & Medicine News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Melafind: Spotting Melanoma Without a Biopsy

Melafind: Spotting Melanoma Without a Biopsy

Ivanhoe (Oct. 31, 2014) The MelaFind device is a pain-free way to check suspicious moles for melanoma, without the need for a biopsy. Video provided by Ivanhoe
Powered by NewsLook.com
Battling Multiple Myeloma

Battling Multiple Myeloma

Ivanhoe (Oct. 31, 2014) The answer isn’t always found in new drugs – repurposing an ‘old’ drug that could mean better multiple myeloma treatment, and hope. Video provided by Ivanhoe
Powered by NewsLook.com
Chronic Inflammation and Prostate Cancer

Chronic Inflammation and Prostate Cancer

Ivanhoe (Oct. 31, 2014) New information that is linking chronic inflammation in the prostate and prostate cancer, which may help doctors and patients prevent cancer in the future. Video provided by Ivanhoe
Powered by NewsLook.com
Sickle Cell: Stopping Kids’ Silent Strokes

Sickle Cell: Stopping Kids’ Silent Strokes

Ivanhoe (Oct. 31, 2014) Blood transfusions are proving crucial to young sickle cell patients by helping prevent strokes, even when there is no outward sign of brain injury. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins