Featured Research

from universities, journals, and other organizations

Research shows advantage to nanotech delivery of therapy for breast cancer brain metastases

Date:
May 1, 2013
Source:
University of North Carolina School of Medicine
Summary:
Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease. Scientists now report pre-clinical research showing improved efficacy of a PEGylated liposomal (encapsulated) anti-cancer agent compared with a non-liposomal formulation of the same drug in an intracranial model of breast cancer.

Chapel Hill -- Breast cancer brain metastases present a challenge to clinicians because there are few systemic therapies capable of crossing the blood-brain barrier to control the disease. An international team, led by scientists at the University of North Carolina Lineberger Comprehensive Cancer Center, reports pre-clinical research showing improved efficacy of a PEGylated liposomal (encapsulated) anti-cancer agent compared with a non-liposomal formulation of the same drug in an intracranial model of breast cancer.

Related Articles


The study results were published online in the May 1, 2013 issue of PLOS ONE.

Carey Anders, MD, assistant professor of medicine and study first author, says, "To our knowledge this study is the first of its kind in brain cancer metastases and offers an informed foundation for the development of early-phase clinical trials. It also offers the potential to improve the current treatment paradigm for patients with intracranial breast cancer recurrence." Dr. Anders is co-director of the UNC Multidisciplinary Brain Metastases Specialty Clinic.

In this study, the scientists used an intracranial model of aggressive triple negative breast cancer to evaluate the pharmacokinetics of a chemotherapy drug, anthracycline doxorubicin in a PEGYlated liposomal-formulation, compared to a non-liposomal formulation. They augmented the liposomal doxorubicin with ABT-888, an inhibitor of an enzyme involved in many cellular functions, called poly (ADP-ribose) polymerase (PARP).

Their results showed that treatment with PEGylated liposomal doxorubicin resulted in a 1500-fold higher plasma and 20-fold higher intracranial tumor bioavailability compared with the non-liposomal doxorubicin. In addition, PEGylated liposomal doxorubicin was detected in in plasma and the intracranial tumor 96 hours following treatment compared to the drug being undetectable in plasma and the tumor after 24 hours in the non-liposomal doxorubicin. Survival rates for the PEGylated liposomal doxorubicin treatment were significantly prolonged as compared to non-liposomal doxorubicin.

UNC authors are: Olga Karginova, MS; Allison Deal, MS; Sumit Rawal, PhD; David Darr, MS; Allison Schorzman, PhD; Charlene Santos, BS; Ryan Bash, MS; Tal Kafri, PhD; Lisa Carey, MD; C. Ryan Miller, MD, PhD; Charles Perou, PhD; Norman Sharpless, MD; and William Zamboni, PharmD, PhD. Barbara Adamo, PhD, is affiliated with UNC and with the University of Messina, Italy.

The research was funded by the National Cancer Institute (K23 and Specialized Program of Research Excellence in Breast Cancer SPORE) and the Breast Cancer Research Foundation.


Story Source:

The above story is based on materials provided by University of North Carolina School of Medicine. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carey K. Anders, Barbara Adamo, Olga Karginova, Allison M. Deal, Sumit Rawal, David Darr, Allison Schorzman, Charlene Santos, Ryan Bash, Tal Kafri, Lisa Carey, C. Ryan Miller, Charles M. Perou, Norman Sharpless, William C. Zamboni. Pharmacokinetics and Efficacy of PEGylated Liposomal Doxorubicin in an Intracranial Model of Breast Cancer. PLoS ONE, 2013; 8 (5): e61359 DOI: 10.1371/journal.pone.0061359

Cite This Page:

University of North Carolina School of Medicine. "Research shows advantage to nanotech delivery of therapy for breast cancer brain metastases." ScienceDaily. ScienceDaily, 1 May 2013. <www.sciencedaily.com/releases/2013/05/130501192927.htm>.
University of North Carolina School of Medicine. (2013, May 1). Research shows advantage to nanotech delivery of therapy for breast cancer brain metastases. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2013/05/130501192927.htm
University of North Carolina School of Medicine. "Research shows advantage to nanotech delivery of therapy for breast cancer brain metastases." ScienceDaily. www.sciencedaily.com/releases/2013/05/130501192927.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins