Featured Research

from universities, journals, and other organizations

Protecting the heart health of diabetic patients

Date:
May 7, 2013
Source:
Cell Press
Summary:
Diabetics have an increased risk of developing coronary artery disease and plaque build-up in their arteries, even if they receive cholesterol-lowering therapies. New research reveals that high blood sugar levels also boost the production of inflammatory cells, which contribute to plaque in blood vessels.

Diabetics have an increased risk of developing coronary artery disease and plaque build-up in their arteries, even if they receive cholesterol-lowering therapies. New research published in the May 7th issue of the Cell Press journal Cell Metabolism reveals that high blood sugar levels also boost the production of inflammatory cells, which contribute to plaque build-up in blood vessels. The researchers identify the cause of this increased production in inflammatory cells and find that blocking this new pathway could help safeguard the heart health of diabetic patients.

"We have found that the bone marrow production of immune cells is affected by high blood sugar and have identified a possible molecule mediating this effect. Both this molecule and its receptor in the bone marrow could be targeted to prevent the inflammation that occurs with type 1 diabetes," says co-senior author Dr. Ira Goldberg of Columbia University College of Physician & Surgeons in New York City.

Dr. Goldberg and his team made their discovery by studying two mouse models of diabetes. In both diabetic models, high blood sugar levels caused a significant increase in the blood counts of certain immune cells called monocytes and neutrophils. The investigators also discovered that neutrophils secrete a molecule called S100A8/S100A9 that interacts with a receptor named RAGE (the Receptor for Advanced Glycation Endproducts) on bone marrow cells. Binding of S100A8/S100A9 to RAGE stimulated bone marrow cells to produce monocytes. This monocyte production created a vicious cycle whereby high blood sugar levels boosted neutrophil numbers, leading to excess secretion of S100A8/S100A9, which in turn stimulated bone marrow cells to produce more monocytes. These monocytes then migrated to blood vessel walls and prevented the healing of plaques.

The researchers found that treating the mice with a drug that lowers blood sugar levels not only reduced the numbers of circulating monocytes and neutrophils but also allowed plaques to normally heal after blood cholesterol was reduced. In addition, blood levels of S100A8/S100A9 in humans with type 1 diabetes correlated with immune cell counts and coronary artery disease.

"These findings illustrate a new marker for risk of vascular disease in patients with type 1 diabetes, and they suggest several new molecular targets for preventing diabetes complications," says Dr. Goldberg.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nagareddy et al. Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metabolism, 2013 DOI: 10.1016/j.cmet.2013.04.001

Cite This Page:

Cell Press. "Protecting the heart health of diabetic patients." ScienceDaily. ScienceDaily, 7 May 2013. <www.sciencedaily.com/releases/2013/05/130507134549.htm>.
Cell Press. (2013, May 7). Protecting the heart health of diabetic patients. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2013/05/130507134549.htm
Cell Press. "Protecting the heart health of diabetic patients." ScienceDaily. www.sciencedaily.com/releases/2013/05/130507134549.htm (accessed July 23, 2014).

Share This




More Health & Medicine News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Courts Conflicted Over Healthcare Law

Courts Conflicted Over Healthcare Law

AP (July 22, 2014) Two federal appeals courts issued conflicting rulings Tuesday on the legality of the federally-run healthcare exchange that operates in 36 states. (July 22) Video provided by AP
Powered by NewsLook.com
Why Do People Believe We Only Use 10 Percent Of Our Brains?

Why Do People Believe We Only Use 10 Percent Of Our Brains?

Newsy (July 22, 2014) The new sci-fi thriller "Lucy" is making people question whether we really use all our brainpower. But, as scientists have insisted for years, we do. Video provided by Newsy
Powered by NewsLook.com
Scientists Find New Way To Make Human Platelets

Scientists Find New Way To Make Human Platelets

Newsy (July 22, 2014) Boston scientists have discovered a new way to create fully functioning human platelets using a bioreactor and human stem cells. Video provided by Newsy
Powered by NewsLook.com
Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins