Featured Research

from universities, journals, and other organizations

Novel approach for influenza vaccination shows promise in early animal testing

Date:
May 22, 2013
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The new vaccine concept represents an important step forward in the quest to develop a universal influenza vaccine -- one that would protect against most or all influenza strains without the need for an annual vaccination.

When ferritin (gray) is fused with the influenza protein hemagglutinin (blue), it self-assembles into a sphere with 8 protruding spikes from its surface.
Credit: NIAID

A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The vaccine concept, which was developed by scientists at the National Institute of Allergy and Infectious Diseases (NIAID), represents an important step forward in the quest to develop a universal influenza vaccine -- one that would protect against most or all influenza strains without the need for an annual vaccination.

The scientists designed an experimental vaccine featuring the protein ferritin, which can self-assemble into microscopic pieces called nanoparticles, as a key component. Ferritin was fused genetically with hemagglutinin (HA), the protein found on the surface of the influenza virus, resulting in a nanoparticle with eight protruding viral spikes. Using this as the basis for the vaccine antigen, the researchers created an experimental vaccine using HA from a 1999 strain of H1N1 influenza virus and evaluated its ability to stimulate an immune response in mice. A single dose of the experimental vaccine both with and without the use of an adjuvant triggered an immune response in the mice comparable to two doses of the currently licensed seasonal influenza vaccine. The experimental vaccine was also active against a wider range of H1N1 influenza virus strains than the licensed vaccine.

The researchers also tested the experimental vaccine's ability to protect ferrets from infection with a 2007 strain of H1N1 influenza virus -- a strain it had not been specifically designed to prevent. One day after exposure to the virus, ferrets that had received the experimental vaccine had significantly lower influenza virus levels than those that were not immunized. According to the study authors, the novel vaccine concept works by stimulating antibodies that hitch themselves to the parts of the influenza virus that stay consistent across different strains. Although further testing is needed, the HA-ferritin nanoparticle approach shows promise for development of more broadly protective vaccines for influenza as well as for other infectious diseases, the authors note.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. Masaru Kanekiyo, Chih-Jen Wei, Hadi M. Yassine, Patrick M. McTamney, Jeffrey C. Boyington, James R. R. Whittle, Srinivas S. Rao, Wing-Pui Kong, Lingshu Wang, Gary J. Nabel. Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies. Nature, 2013; DOI: 10.1038/nature12202

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "Novel approach for influenza vaccination shows promise in early animal testing." ScienceDaily. ScienceDaily, 22 May 2013. <www.sciencedaily.com/releases/2013/05/130522160350.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2013, May 22). Novel approach for influenza vaccination shows promise in early animal testing. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2013/05/130522160350.htm
NIH/National Institute of Allergy and Infectious Diseases. "Novel approach for influenza vaccination shows promise in early animal testing." ScienceDaily. www.sciencedaily.com/releases/2013/05/130522160350.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins