Featured Research

from universities, journals, and other organizations

Circadian rhythms control body's response to intestinal infections

Date:
May 31, 2013
Source:
University of California - Irvine
Summary:
Circadian rhythms can boost the body's ability to fight intestinal bacterial infections, researchers have found.

Circadian rhythms can boost the body's ability to fight intestinal bacterial infections, UC Irvine researchers have found.

Related Articles


This suggests that targeted treatments may be particularly effective for pathogens such as salmonella that prompt a strong immune system response governed by circadian genes. It also helps explain why disruptions in the regular day-night pattern -- as experienced by, say, night-shift workers or frequent fliers -- may raise susceptibility to infectious diseases.

UC Irvine's Paolo Sassone-Corsi, one of the world's leading researchers on circadian rhythm genetics, and microbiologist Manuela Raffatellu led the study, which appears this week in the early online edition of Proceedings of the National Academy of Sciences. Marina Bellet, a postdoctoral researcher from Italy's University of Perugia also played a key role in the experiments.

"Although many immune responses are known to follow daily oscillations, the role of the circadian clock in the immune response to acute infections has not been understood," said Sassone-Corsi, the Donald Bren Professor of Biological Chemistry. "What we're learning is that the intrinsic power of the body clock can help fight infections."

Circadian rhythms of 24 hours govern fundamental physiological functions in almost all organisms. The circadian clock is an intrinsic time-tracking system in the human body that anticipates environmental changes and adapts to the appropriate time of day. Disruption of these normal rhythms can profoundly influence people's health.

Up to 15 percent of human genes are regulated by the day-night pattern of circadian rhythms, including those that respond to intestinal infections.

In tests on mice infected with salmonella, the researchers noted that circadian-controlled genes govern the immune response to the invading pathogen, leading to day-night differences in infection potential and in the immune system's ability to deal with pathogens.

Mice are nocturnal, with circadian rhythms opposite those of humans. While important differences exist in the immune response of mice and humans, Sassone-Corsi said, these test results could provide clues to how circadian-controlled intestinal genes regulate daily changes in the effectiveness of the human immune system.

"Salmonella is a good pathogen to study what happens during infection," said Raffatellu, assistant professor of microbiology & molecular genetics. "We think these findings may be broadly applicable to other infectious diseases in the gut, and possibly in other organs controlled by circadian patterns."

Sassone-Corsi added that it's important to understand the circadian genetics regulating immunity. "This gives us the ability to target treatments that supplement the power of the body clock to boost immune response," he said.

Elisa Deriu, Janet Liu, Benedetto Grimaldi, Christoph Blaschitz, Michael Zeller, Robert Edwards, Saurabh Sahar and Pierre Baldi of UC Irvine; and Satya Dandekar and Michael George of UC Davis contributed to the study, which was supported by the National Institutes of Health (grants R01-GM081634, LM010235-01A1, T32 AI60573, AI083619, AI083663 and 5T15LM007743), the National Science Foundation (grant MRI EIA-0321390), Sirtris Pharmaceuticals Inc. and an American Heart Association predoctoral fellowship.

Bellet, Grimaldi and Sahar are affiliated with UC Irvine's Center for Epigentics & Metabolism, which is directed by Sassone-Corsi.


Story Source:

The above story is based on materials provided by University of California - Irvine. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. M. Bellet, E. Deriu, J. Z. Liu, B. Grimaldi, C. Blaschitz, M. Zeller, R. A. Edwards, S. Sahar, S. Dandekar, P. Baldi, M. D. George, M. Raffatellu, P. Sassone-Corsi. Circadian clock regulates the host response to Salmonella. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1120636110

Cite This Page:

University of California - Irvine. "Circadian rhythms control body's response to intestinal infections." ScienceDaily. ScienceDaily, 31 May 2013. <www.sciencedaily.com/releases/2013/05/130531132623.htm>.
University of California - Irvine. (2013, May 31). Circadian rhythms control body's response to intestinal infections. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2013/05/130531132623.htm
University of California - Irvine. "Circadian rhythms control body's response to intestinal infections." ScienceDaily. www.sciencedaily.com/releases/2013/05/130531132623.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins