Featured Research

from universities, journals, and other organizations

Metastatic tumors: New path in immunotherapy

Date:
June 3, 2013
Source:
National Cancer Institute (NCI) at NIH
Summary:
Cancer immunotherapy is showing promise in treating patients with a variety of advanced, metastatic tumors, as evidenced by two newly unveiled studies.

Cancer immunotherapy is showing promise in treating patients with a variety of advanced, metastatic tumors, as evidenced by two newly unveiled studies from Yale Cancer Center. The research will be formally presented at the 2013 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago, but abstracts were made public by ASCO in advance of the meeting. Yale was a lead trial site for both studies.

Related Articles


Both are Phase 1 clinical trials. The first study involved an investigational antibody drug, known as MPDL3280A and manufactured by Roche Genentech, which was designed to prevent a cancer cell's overexpressed PD-L1 protein from putting the immune system to sleep. The overexpressed PD-L1 protein turns off the immune system's T-cells by binding to its PD-1 and B7.1 proteins. In doing so, it disguises itself and evades detection and destruction by the body's immune response.

This new drug is the latest advance in the burgeoning field of immunotherapy, which aims to boost the body's immune system to fight cancer. In blocking the cancer tumor's PD-L1 protein, MPDL3280A frees the immune system to do its job. This PD-L1 targeted antibody was specially engineered to increase safety and efficacy over earlier immunotherapy agents.

Yale oncologists report that the efficacy of MPDL3280A was evaluated in 140 patients with locally advanced or metastatic solid tumors who had exhausted other means of therapy. Tumor shrinkage was observed in patients with non-small cell lung cancer, melanoma, kidney cancer, colorectal cancer and gastric cancer. Yale oncologists say ongoing, durable responses were observed in nearly all patients who responded to the drug. Overall, 29 out of 140 patients (21 percent) experienced significant tumor shrinkage, and the highest number of responses were in patients with lung cancer and melanoma. MPDL3280A was generally well tolerated, they say, with few immune-related adverse events. Some patients were continuing to respond more than a year after starting treatment.

"We have been very impressed by the response in seriously ill patients whose cancer had metastasized. So far, almost none of those who showed tumor shrinkage have gotten worse, which is extraordinary," said lead investigator Dr. Roy Herbst, the Ensign Professor of Medical Oncology and chief of medical oncology at Yale Cancer Center and Smilow Cancer Hospital at Yale-New Haven. "Immunotherapy treatment is providing new hope for cancer patients," he added.

In the second Phase 1 study, researchers from Memorial Sloan-Kettering (lead author), Yale Cancer Center (senior author), and elsewhere, presented data that evaluated the safety and efficacy of combining immunotherapy drugs -- nivolumab and ipilimumab -- in treating advanced melanoma. Each drug had been known to prolong survival or produce durable tumor regressions in some patients when administered individually, but combining them produced superior clinical results, researchers report, with rapid and deep tumor regressions in many patients.

Both CTLA-4 and PD-1 are targets for cancer immunotherapy because they shut down the immune system's ability to respond to foreign invaders. Nivolumab targets the PD-1 receptor on the surface of T-cells, and ipilimumab targets the CTLA-4 receptors. Both nivolumab and ipilimumab are manufactured by Bristol Myers Squibb.

Researchers provided data for 86 patients in this Phase 1 trial. They report that responses were generally durable, even in patients whose treatment was terminated early.

According to senior author Dr. Mario Sznol, clinical research leader of the melanoma program at Yale Cancer Center, this early success in combining drugs may pave the way for large-scale combination immunotherapy trials. "After many years, we are finally realizing the promise of immunotherapy in providing real and durable benefit for advanced cancer patients. Although this trial was focused on melanoma, the combination will be studied in other cancer types. This is only one of many combinations of agents that will likely lead to even more significant advances in cancer treatment," Sznol said.

The first author on this study was Dr. Jedd Wolchok of Memorial Sloan-Kettering Cancer Center.


Story Source:

The above story is based on materials provided by National Cancer Institute (NCI) at NIH. Note: Materials may be edited for content and length.


Cite This Page:

National Cancer Institute (NCI) at NIH. "Metastatic tumors: New path in immunotherapy." ScienceDaily. ScienceDaily, 3 June 2013. <www.sciencedaily.com/releases/2013/06/130603113146.htm>.
National Cancer Institute (NCI) at NIH. (2013, June 3). Metastatic tumors: New path in immunotherapy. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2013/06/130603113146.htm
National Cancer Institute (NCI) at NIH. "Metastatic tumors: New path in immunotherapy." ScienceDaily. www.sciencedaily.com/releases/2013/06/130603113146.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins