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First dual-action compound kills cancer cells, stops them from spreading

Date:
June 5, 2013
Source:
American Chemical Society
Summary:
Scientists are reporting development and successful lab tests on the first potential drug to pack a lethal one-two punch against melanoma skin cancer cells. Hit number one destroys cells in the main tumor, and the second hit blocks the spread of the cancer to other sites in the body, according to their report.
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Scientists are reporting development and successful lab tests on the first potential drug, used in concert with a laser, to pack a lethal one- two punch against melanoma skin cancer cells.
Credit: National Cancer Institute, John Crawford

Scientists are reporting development and successful lab tests on the first potential drug to pack a lethal one-two punch against melanoma skin cancer cells. Hit number one destroys cells in the main tumor, and the second hit blocks the spread of the cancer to other sites in the body, according to their report in the journal ACS Chemical Biology.

Nathan Luedtke and colleagues explain that the spread of melanoma and other forms of cancer beyond the original location -- a process called metastasis -- makes cancer such a serious disease. Photodynamic therapy (PDT), which involves administering a drug that kills cancer cells when exposed to light, already is available. But PDT works only on the main tumor and has other drawbacks. Luedtke's team set out to find an improved approach to PDT.

The scientists describe successful tests in laboratory mice of one compound they synthesized that not only killed melanoma cells, but also stopped them from metastasizing by blocking a key signal inside the tumor cells. The compound "provides the first example of a preclinical candidate possessing both of these properties," the scientists state.

The authors acknowledge funding from the Swiss National Science Foundation.


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The above post is reprinted from materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Balayeshwanth R. Vummidi, Faiza Noreen, Jawad Alzeer, Karin Moelling, Nathan W. Luedtke. Photodynamic Agents with Anti-metastatic Activities. ACS Chemical Biology, 2013; 130528091646004 DOI: 10.1021/cb400008t

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American Chemical Society. "First dual-action compound kills cancer cells, stops them from spreading." ScienceDaily. ScienceDaily, 5 June 2013. <www.sciencedaily.com/releases/2013/06/130605130213.htm>.
American Chemical Society. (2013, June 5). First dual-action compound kills cancer cells, stops them from spreading. ScienceDaily. Retrieved July 28, 2015 from www.sciencedaily.com/releases/2013/06/130605130213.htm
American Chemical Society. "First dual-action compound kills cancer cells, stops them from spreading." ScienceDaily. www.sciencedaily.com/releases/2013/06/130605130213.htm (accessed July 28, 2015).

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