Featured Research

from universities, journals, and other organizations

Early exposure to bisphenol A might damage the enamel of teeth

Date:
June 10, 2013
Source:
INSERM (Institut national de la santé et de la recherche médicale)
Summary:
Are teeth the latest victims of bisphenol A? Yes, according to the conclusions of new work. Researchers have shown that the teeth of rats treated with low daily doses of BPA could be damaged by this.

Analysis of teeth of rats exposed to bisphenol A showed numerous characteristics in common with a tooth enamel pathology known as MIH (Molar Incisor Hypomineralisation) that selectively affects first molars and permanent incisors. This enamel pathology is found in roughly 18% of children between the ages of 6 and 8. Children affected by this pathology present with teeth that are hypersensitive to pain and liable to cavities.
Credit: © evasilchenko / Fotolia

Are teeth the latest victims of bisphenol A? Yes, according to the conclusions of work carried out by the research team led by Ariane Berdal of the Université Paris-Diderot and Sylvie Babajko, Research Director at Inserm Unit 872 "Centre des Cordeliers." The researchers have shown that the teeth of rats treated with low daily doses of BPA could be damaged by this.Analysis of the damage shows numerous characteristics that are common with a recently identified pathology of tooth enamel that affects roughly 18% of children between the ages of 6 and 8.

Bisphenol A (BPA) is a chemical compound used in the composition of plastics and resins. It is used for example to manufacture food containers such as bottles or babies' bottles. It is also used for the protective films inside drinks cans and food tins, or as developers on sales receipts. Significant amounts of BPA have also been found in human blood, urine, amniotic liquid and placentas. Recent studies have shown that this industrial compound has adverse effects on the reproduction, development and metabolism of laboratory animals. It is strongly suspected of having the same effects on humans.

As a precautionary measure, the manufacture and commercialisation of babies' bottles containing bisphenol A were prohibited in Europe in January 2011. The prohibition will be extended to all food containers in France as from July 2015.

So this study shows that teeth are the latest in an already long list of victims of BPA.

The Inserm researchers have shown that the incisors of rats treated with low daily doses of BPA (5 microgrammes/kg/day) could be damaged by this.

This effect has also been observed within a development window of no more than 30 days post-birth in rats, thus demonstrating a range of sensitivity to exposure.

Analysis of these teeth showed numerous characteristics that are common with a tooth enamel pathology known as MIH (Molar Incisor Hypomineralisation) that selectively affects first molars and permanent incisors. This enamel pathology is found in roughly 18% of children between the ages of 6 and 8. Children affected by this pathology present with teeth that are hypersensitive to pain and liable to cavities. It is interesting to note that the period during which these teeth are formed (the first years of life) correspond to the period during which humans are most sensitive to bisphenol A.

Amongst the earliest observations made was the appearance of "white marks" on the incisors of rats treated with endocrine disruptors, one of which was bisphenol A (BPA). The researchers decided to define the characteristics of incisors of rats treated with low doses of BPA and to compare these with the characteristics of teeth in humans suffering from MIH

Macroscopic observation of marks on both series of teeth showed similarities, in particular fragile and brittle enamel.

Microscope observation of the enamel showed a significant reduction of the Ca/P and the Ca/C ratios in affected teeth. This leads to mineral depletion, making the teeth more fragile and more liable to cavities.

Finally, analysis of the proteins present in the tooth matrix of rats showed an increased quantity of enamelin, a key protein for enamel formation, and a buildup of albumin leading to hypomineralisation. Analysis of the expression of key enamel genes highlighted two BPA target genes: enamelin and kallicrein 4.

According to Sylvie Babajko, the latest author of this article, "Insofar as BPA has the same mechanism of action in rats as in men, it could also be a causal agent of MIH. Therefore, teeth could be used as early markers of exposure to endocrine disruptors acting in the same way as BPA and so could help in early detection of serious pathologies that would otherwise have occurred several years later."


Story Source:

The above story is based on materials provided by INSERM (Institut national de la santé et de la recherche médicale). Note: Materials may be edited for content and length.


Journal Reference:

  1. Katia Jedeon, Muriel De la Dure-Molla, Steven J. Brookes, Sophia Loiodice, Clémence Marciano, Jennifer Kirkham, Marie-Chantal Canivenc-Lavier, Sofiane Boudalia, Raymond Bergès, Hidemitsu Harada, Ariane Berdal, Sylvie Babajko. Enamel Defects Reflect Perinatal Exposure to Bisphenol A. The American Journal of Pathology, 2013; DOI: 10.1016/j.ajpath.2013.04.004

Cite This Page:

INSERM (Institut national de la santé et de la recherche médicale). "Early exposure to bisphenol A might damage the enamel of teeth." ScienceDaily. ScienceDaily, 10 June 2013. <www.sciencedaily.com/releases/2013/06/130610133246.htm>.
INSERM (Institut national de la santé et de la recherche médicale). (2013, June 10). Early exposure to bisphenol A might damage the enamel of teeth. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2013/06/130610133246.htm
INSERM (Institut national de la santé et de la recherche médicale). "Early exposure to bisphenol A might damage the enamel of teeth." ScienceDaily. www.sciencedaily.com/releases/2013/06/130610133246.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) — Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins