Featured Research

from universities, journals, and other organizations

Stem cells reach standard for use in drug development

Date:
June 11, 2013
Source:
University of Edinburgh
Summary:
Drug development for a range of conditions could be improved with stem cell technology that helps doctors predict the safety and the effectiveness of potential treatments. Researchers in the UK have been able to generate cells in the laboratory that reach the gold standard required by the pharmaceutical industry to test drug safety.

Drug development for a range of conditions could be improved with stem cell technology that helps doctors predict the safety and the effectiveness of potential treatments.

University scientists have been able to generate cells in the laboratory that reach the gold standard required by the pharmaceutical industry to test drug safety.

Generating liver cells

The researchers used stem cell technology to generate liver cells -- which help our bodies to process drugs.

They found that the cells were equally effective, reaching the same standard, as cells from human liver tissue currently used to assess drug safety.

These human cells used in drug testing are in short supply and vary considerably due to different donors. As a result they are not an ideal source for drug development.

The stem cell based technique developed in Edinburgh, addresses these issues by offering a renewable production of uniform liver cells in the laboratory.

"Differing genetic information plays a key role in how patients' livers process drugs. We are now able to efficiently produce human liver cells in the laboratory from different people which model the functional differences in human genetics," said Dr David Hay, of the Medical Research Centre (MRC) for Regenerative Medicine at the University.

Researchers hope to generate liver cells, containing different DNA to reflect the genetic variations in metabolism found in the population

Such cells could be used to help identify differences in response among patients to certain drugs.

The laboratory-generated liver cells could also be used to screen certain drugs that need close monitoring, to optimise patient treatment.

Scientists are working with Edinburgh BioQuarter, with a view to forming a spin-out company to commercialise the research.

Research

The research is published in the journal Stem Cells Translational Medicine.

It involved collaboration between the MRC Centre for Regenerative Medicine, the MRC Centre for Inflammation Research and the School of Chemistry at the University of Edinburgh with Bristol-Myers Squibb.

The research received funding from the Engineering and Physical Sciences Research Council, Edinburgh BioQuarter and in kind support from Bristol-Myers Squibb.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Claire N. Medine, Baltasar Lucendo-Villarin, Christopher Storck, Faye Wang, Dagmara Szkolnicka, Ferdous Khan, Salvatore Pernagallo, James R. Black, Howard M. Marriage, James A. Ross, Mark Bradley, John P. Iredale, Oliver Flint, David C. Hay. Developing High-Fidelity Hepatotoxicity Models From Pluripotent Stem Cells. Stem Cells Translational Medicine, 2013; DOI: 10.5966/sctm.2012-0138

Cite This Page:

University of Edinburgh. "Stem cells reach standard for use in drug development." ScienceDaily. ScienceDaily, 11 June 2013. <www.sciencedaily.com/releases/2013/06/130611111712.htm>.
University of Edinburgh. (2013, June 11). Stem cells reach standard for use in drug development. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2013/06/130611111712.htm
University of Edinburgh. "Stem cells reach standard for use in drug development." ScienceDaily. www.sciencedaily.com/releases/2013/06/130611111712.htm (accessed July 22, 2014).

Share This




More Health & Medicine News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

Gilead's $1000-a-Pill Drug Could Cure Hep C in HIV-Positive People

TheStreet (July 21, 2014) New research shows Gilead Science's drug Sovaldi helps in curing hepatitis C in those who suffer from HIV. In a medical study, the combination of Gilead's Hep C drug with anti-viral drug Ribavirin cured 76% of HIV-positive patients suffering from the most common hepatitis C strain. Hepatitis C and related complications have been a top cause of death in HIV-positive patients. Typical medication used to treat the disease, including interferon proteins, tended to react badly with HIV drugs. However, Sovaldi's %1,000-a-pill price tag could limit the number of patients able to access the treatment. TheStreet's Keris Lahiff reports from New York. Video provided by TheStreet
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com
Tooth Plaque Provides Insight Into Diets Of Ancient People

Tooth Plaque Provides Insight Into Diets Of Ancient People

Newsy (July 19, 2014) Research on plaque from ancient teeth shows that our prehistoric ancestor's had a detailed understanding of plants long before developing agriculture. Video provided by Newsy
Powered by NewsLook.com
Contaminated Water Kills 3 Babies in South African Town

Contaminated Water Kills 3 Babies in South African Town

AFP (July 18, 2014) Contaminated water in South Africa's northwestern town of Bloemhof kills three babies and hospitalises over 500 people. The incident highlights growing fears over water safety in South Africa. Duration: 02:22 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins