Featured Research

from universities, journals, and other organizations

Stem cells reach standard for use in drug development

Date:
June 11, 2013
Source:
University of Edinburgh
Summary:
Drug development for a range of conditions could be improved with stem cell technology that helps doctors predict the safety and the effectiveness of potential treatments. Researchers in the UK have been able to generate cells in the laboratory that reach the gold standard required by the pharmaceutical industry to test drug safety.

Drug development for a range of conditions could be improved with stem cell technology that helps doctors predict the safety and the effectiveness of potential treatments.

University scientists have been able to generate cells in the laboratory that reach the gold standard required by the pharmaceutical industry to test drug safety.

Generating liver cells

The researchers used stem cell technology to generate liver cells -- which help our bodies to process drugs.

They found that the cells were equally effective, reaching the same standard, as cells from human liver tissue currently used to assess drug safety.

These human cells used in drug testing are in short supply and vary considerably due to different donors. As a result they are not an ideal source for drug development.

The stem cell based technique developed in Edinburgh, addresses these issues by offering a renewable production of uniform liver cells in the laboratory.

"Differing genetic information plays a key role in how patients' livers process drugs. We are now able to efficiently produce human liver cells in the laboratory from different people which model the functional differences in human genetics," said Dr David Hay, of the Medical Research Centre (MRC) for Regenerative Medicine at the University.

Researchers hope to generate liver cells, containing different DNA to reflect the genetic variations in metabolism found in the population

Such cells could be used to help identify differences in response among patients to certain drugs.

The laboratory-generated liver cells could also be used to screen certain drugs that need close monitoring, to optimise patient treatment.

Scientists are working with Edinburgh BioQuarter, with a view to forming a spin-out company to commercialise the research.

Research

The research is published in the journal Stem Cells Translational Medicine.

It involved collaboration between the MRC Centre for Regenerative Medicine, the MRC Centre for Inflammation Research and the School of Chemistry at the University of Edinburgh with Bristol-Myers Squibb.

The research received funding from the Engineering and Physical Sciences Research Council, Edinburgh BioQuarter and in kind support from Bristol-Myers Squibb.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. Claire N. Medine, Baltasar Lucendo-Villarin, Christopher Storck, Faye Wang, Dagmara Szkolnicka, Ferdous Khan, Salvatore Pernagallo, James R. Black, Howard M. Marriage, James A. Ross, Mark Bradley, John P. Iredale, Oliver Flint, David C. Hay. Developing High-Fidelity Hepatotoxicity Models From Pluripotent Stem Cells. Stem Cells Translational Medicine, 2013; DOI: 10.5966/sctm.2012-0138

Cite This Page:

University of Edinburgh. "Stem cells reach standard for use in drug development." ScienceDaily. ScienceDaily, 11 June 2013. <www.sciencedaily.com/releases/2013/06/130611111712.htm>.
University of Edinburgh. (2013, June 11). Stem cells reach standard for use in drug development. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2013/06/130611111712.htm
University of Edinburgh. "Stem cells reach standard for use in drug development." ScienceDaily. www.sciencedaily.com/releases/2013/06/130611111712.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com
Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins