Featured Research

from universities, journals, and other organizations

Chemical in antibacterial soap fed to nursing rats harms offspring, study finds

Date:
June 17, 2013
Source:
Endocrine Society
Summary:
A mother's exposure to triclocarban, a common antibacterial chemical, while nursing her babies shortens the life of her female offspring, a new study in rats finds.

A mother’s exposure to triclocarban, a common antibacterial chemical, while nursing her babies shortens the life of her female offspring, a new study in rats finds.
Credit: © Elenathewise / Fotolia

A mother's exposure to triclocarban, a common antibacterial chemical, while nursing her babies shortens the life of her female offspring, a new study in rats finds.

Related Articles


The results were presented Monday at The Endocrine Society's 95th Annual Meeting in San Francisco.

Commonly used in antibacterial soap and other personal care products, triclocarban has the potential for a large portion of the public to be exposed to it, said the study's lead author, Rebekah Kennedy, a graduate student in the Department of Public Health at the University of Tennessee, Knoxville.

"Our study provides supporting evidence for the potential adverse effects of triclocarban exposure during early life, specifically during the lactation period," Kennedy said. "The results indicate that a mother's long-term use of this compound might affect the early development of her offspring, at least according to our animal model."

Past studies by the senior investigator, Jiangang Chen, PhD, an assistant professor at the University of Tennessee, showed that triclocarban enhances the growth of sex organs in the adult male rat. In this study, the researchers sought to learn if exposure to the same compound, either in the womb or during lactation, would affect rat pups.

Beginning on pregnancy day 5 and continuing until 21 days after giving birth, maternal rats continuously had free access to regular rat chow (the control rats) or chow supplemented with either 0.2 or 0.5 percent triclocarban. The doses found in the blood of maternal rats exposed to triclocarban correspond to blood levels of triclocarban in humans after a 15-minute whole-body shower using a bar soap containing 0.6 percent triclocarban, Chen said.

After birth, some littermates were moved to other groups so that each rat mother nursed two of her own pups and two pups from each of the other two groups. The offspring were weighed daily.

Body weight did not differ at birth among rat pups from the three groups, but by day 3, pups nursed by control rats were heavier than either triclocarban-exposed group, Kennedy reported. Pups nursed by rats that received 0.2 percent triclocarban were about half as heavy at weaning on day 21 as pups nursed by controls, and only 4 of 30 pups survived.

The investigators found that all pups nursed by the control rats survived until weaning, including those born to triclocarban-fed maternal rats but nursed by control rats. No pups nursed by rats that received the larger triclocarban dose, 0.5 percent, survived until day 6. Among pups nursed by rats that received the 0.2 percent dose of triclocarban, 57 percent reportedly lived to nine days after birth, and only 13% survived after weaning.

"Our data suggest that the critical exposure window affecting rat pup survival is related to lactation, as all pups raised by control rats survived regardless of triclocarban exposure status during gestation," Kennedy said.

Although the researchers did not measure triclocarban levels in the offspring, they speculate that the chemical entered the gastrointestinal tract through the mother's milk and affected the pups' growth and development.

The National Institutes of Health's National Institute of Environmental Health Sciences supported this research.


Story Source:

The above story is based on materials provided by Endocrine Society. Note: Materials may be edited for content and length.


Cite This Page:

Endocrine Society. "Chemical in antibacterial soap fed to nursing rats harms offspring, study finds." ScienceDaily. ScienceDaily, 17 June 2013. <www.sciencedaily.com/releases/2013/06/130617122146.htm>.
Endocrine Society. (2013, June 17). Chemical in antibacterial soap fed to nursing rats harms offspring, study finds. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2013/06/130617122146.htm
Endocrine Society. "Chemical in antibacterial soap fed to nursing rats harms offspring, study finds." ScienceDaily. www.sciencedaily.com/releases/2013/06/130617122146.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) — Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins