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Protocells may have formed in a salty soup

Date:
July 2, 2013
Source:
Radboud University Nijmegen
Summary:
The first cell may have originated in a salty soup in which large biomolecules cluster spontaneously to form a protocell, chemists in the Netherlands have discovered.
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Artist's illustration of cells (stock image).
Credit: © Jezper / Fotolia

The first cell may have originated in a salty soup in which large biomolecules cluster spontaneously to form a protocell, chemists at Radboud University Nijmegen discovered.

The research is published in the Proceedings of the National Academy of Sciences.

How did the first cell originate in evolution? It is a chicken or the egg causality dilemma: a cell doesn't function without a cell wall, but how does the cell wall form if there is no cell? Research by chemist Wilhelm Huck, professor at Radboud University Nijmegen, suggests that the cell came first.

In a solution containing the biomolecules that are normally locked in a cell (like DNA, RNA, enzymes, proteins) these large biomolecules clustered together spontaneously when the salt concentration was increased. This indicates that a cell wall is not a prerequisite for a cell-like structure .

Huck thinks the macro molecules in our cells evolved to do their work while packed closely together. By using tiny droplets, he explores how this works exactly. "When biomolecules are packed together, we expect reactions to proceed much faster. They perform their chemistry much more efficiently. In this study, we measure a fifty-fold increase in the DNA transcription rate."

A working cell is more than the sum of its parts. "A functioning cell must be entirely correct at once, in all its complexity," said Huck. "We are now closer to building a synthetic cell than anyone ever before us."


Story Source:

The above story is based on materials provided by Radboud University Nijmegen. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Sokolova, E. Spruijt, M. M. K. Hansen, E. Dubuc, J. Groen, V. Chokkalingam, A. Piruska, H. A. Heus, W. T. S. Huck. Enhanced transcription rates in membrane-free protocells formed by coacervation of cell lysate. Proceedings of the National Academy of Sciences, 2013; DOI: 10.1073/pnas.1222321110

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Radboud University Nijmegen. "Protocells may have formed in a salty soup." ScienceDaily. ScienceDaily, 2 July 2013. <www.sciencedaily.com/releases/2013/07/130702100115.htm>.
Radboud University Nijmegen. (2013, July 2). Protocells may have formed in a salty soup. ScienceDaily. Retrieved May 5, 2015 from www.sciencedaily.com/releases/2013/07/130702100115.htm
Radboud University Nijmegen. "Protocells may have formed in a salty soup." ScienceDaily. www.sciencedaily.com/releases/2013/07/130702100115.htm (accessed May 5, 2015).

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