Featured Research

from universities, journals, and other organizations

Single men, smokers at higher risk for oral human papillomavirus infection

Date:
July 3, 2013
Source:
Moffitt Cancer Center
Summary:
Smokers and single men are more likely to acquire cancer-causing oral human papillomavirus (HPV), according to new results from the HPV Infection in Men (HIM) Study. Researchers also report that newly acquired oral HPV infections in healthy men are rare and when present, usually resolve within one year.

Smokers and single men are more likely to acquire cancer-causing oral human papillomavirus (HPV), according to new results from the HPV Infection in Men (HIM) Study. Researchers from Moffitt Cancer Center, the National Cancer Institute, Mexico and Brazil also report that newly acquired oral HPV infections in healthy men are rare and when present, usually resolve within one year.

The study results appeared in the July issue of The Lancet.

HPV infection is known to cause virtually all cervical cancers, most anal cancers and some genital cancers. It has recently been established as a cause of the majority of oropharyngeal cancers, a malignancy of the tonsils and base of tongue.

HPV-related oropharyngeal cancer is rare, but rates have been increasing rapidly, especially among men. To determine the pattern of HPV acquisition and persistence in the oral region, researchers evaluated the HPV infection status in oral mouthwash samples collected as part of the HIM Study, which was originally designed to evaluate the natural history of genital HPV infections in healthy men.

"Some types of HPV, such as HPV16, are known to cause cancer at multiple places in the body, including the oral cavity," said study lead author Christine M. Pierce Campbell, Ph.D., M.P.H., a postdoctoral fellow in Moffitt's Center for Infection Research in Cancer. "We know that HPV infection is associated with oropharyngeal cancer, but we don't know how the virus progresses from initial infection to cancer in the oral cavity. One aspect of the HIM Study is to gather data to help us understand the natural history of these infections."

During the first 12 months, nearly 4.5 percent of men in the study acquired an oral HPV infection. Less than 1 percent of men in the study had an HPV16 infection, the most commonly acquired type, and less than 2 percent had a cancer-causing type of oral HPV.

Their findings are consistent with previous studies showing a low prevalence of oral HPV cancers. However, this study shows the acquisition of cancer-causing oral HPV appeared greater among smokers and unmarried men.

"Additional HPV natural history studies are needed to better inform the development of infection-related prevention efforts," said Anna R. Giuliano, Ph.D., director of Moffitt's Center for Infection Research in Cancer. "HPV16 is associated with the rapid increase in incidence of oropharyngeal cancer, most noticeably in the United States, Sweden and Australia, where it is responsible for more than 50 percent of cases. Unfortunately, there are no proven methods to prevent or detect these cancers at an early stage."

The researchers note that persistent oral HPV16 infection may be a precursor to oropharyngeal cancer, similar to how persistent cervical HPV infection leads to cervical pre-cancer.

Funding for the study was provided by National Cancer Institute grants (CA R01CA098803, R25T CA147832) and the National Cancer Institute Intramural Research Program.


Story Source:

The above story is based on materials provided by Moffitt Cancer Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Aimιe R Kreimer, Christine M Pierce Campbell, Hui-Yi Lin, William Fulp, Mary R Papenfuss, Martha Abrahamsen, Allan Hildesheim, Luisa L Villa, Jorge J Salmerσn, Eduardo Lazcano-Ponce, Anna R Giuliano. Incidence and clearance of oral human papillomavirus infection in men: the HIM cohort study. The Lancet, 2013; DOI: 10.1016/S0140-6736(13)60809-0

Cite This Page:

Moffitt Cancer Center. "Single men, smokers at higher risk for oral human papillomavirus infection." ScienceDaily. ScienceDaily, 3 July 2013. <www.sciencedaily.com/releases/2013/07/130703100912.htm>.
Moffitt Cancer Center. (2013, July 3). Single men, smokers at higher risk for oral human papillomavirus infection. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/07/130703100912.htm
Moffitt Cancer Center. "Single men, smokers at higher risk for oral human papillomavirus infection." ScienceDaily. www.sciencedaily.com/releases/2013/07/130703100912.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) — An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) — America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) — The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) — The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins