Featured Research

from universities, journals, and other organizations

Novel chemistry for new class of antibiotic

Date:
July 3, 2013
Source:
University of Adelaide
Summary:
Research out of Australia has produced a potential new antibiotic which could help in the battle against bacterial resistance to antibiotics.

University of Adelaide research has produced a potential new antibiotic which could help in the battle against bacterial resistance to antibiotics.

The potential new antibiotic targets a bacterial enzyme critical to metabolic processes.

The compound is a protein inhibitor which binds to the enzyme (called biotin protein ligase), stopping its action and interrupting the life cycle of the bacteria.

"Existing antibiotics target the bacterial cell membranes but this potential new antibiotic operates in a completely different way," says Professor Andrew Abell, project leader and Acting Head of the University's School of Chemistry and Physics.

Professor Abell says the compound, although at a very early stage of development -- it has not yet been tested on an animal model -- has the potential to become the first of a new class of antibiotics.

"Bacteria quickly build resistance against the known classes of antibiotics and this is causing a significant global health problem," he says. "Preliminary results show that this new class of compound may be effective against a wide range of bacterial diseases, including tuberculosis which has developed a strain resistant to all known antibiotics."

Developing the new protein inhibitor involved a novel approach called 'in situ click chemistry'. A selection of small molecules, or 'precursor fragments', are presented to the bacteria in a way so that the target protein enzyme itself builds the inhibiting compound and also binds with it.

"In a sense the bacteria unwittingly chooses a compound that will stop its growth and assembles it -- like building a weapon and using it against itself," says Professor Abell. "We've gone a step further to specifically engineer the enzyme so that it builds the best and most potent weapon."

"Our results are promising. We've made the compounds; we know they bind and inhibit this enzyme and we've shown they stop the growth of a range of bacteria in the laboratory. The next critical step will be investigating their efficacy in an animal model."

"Thanks to this new approach what might have taken a year or more with a range of sequential experiments, we can now do in one single experiment," Professor Abell says.

The research has been published in the journal Chemical Science and is in collaboration with researchers at Monash University and Adelaide's Women's and Children's Hospital.


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. William Tieu, Tatiana P. Soares da Costa, Min Y. Yap, Kelly L. Keeling, Matthew C. J. Wilce, John C. Wallace, Grant W. Booker, Steven W. Polyak, Andrew D. Abell. Optimising in situ click chemistry: the screening and identification of biotin protein ligase inhibitors. Chemical Science, 2013; DOI: 10.1039/C3SC51127H

Cite This Page:

University of Adelaide. "Novel chemistry for new class of antibiotic." ScienceDaily. ScienceDaily, 3 July 2013. <www.sciencedaily.com/releases/2013/07/130703100918.htm>.
University of Adelaide. (2013, July 3). Novel chemistry for new class of antibiotic. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2013/07/130703100918.htm
University of Adelaide. "Novel chemistry for new class of antibiotic." ScienceDaily. www.sciencedaily.com/releases/2013/07/130703100918.htm (accessed September 1, 2014).

Share This




More Plants & Animals News

Monday, September 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Washington Wildlife Center Goes Nuts Over Baby Squirrels

Washington Wildlife Center Goes Nuts Over Baby Squirrels

Reuters - US Online Video (Aug. 30, 2014) An animal rescue in Washington state receives an influx of orphaned squirrels, keeping workers busy as they nurse them back to health. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins