Featured Research

from universities, journals, and other organizations

New technology will improve neuron activation induced by cochlear implants

Date:
July 17, 2013
Source:
Neural Regeneration Research
Summary:
Cochlear implants, electrical prosthetic devices that stimulate inner ear neurons of individuals who have lost their cochlear sensory cells, restore usable hearing to deaf patients.

These are confocal images of spiral ganglion neurites co-cultured with neurotrophin-producing fibroblasts. As above, neurites were immunostained for neurofilament 200 (Texas Red) and FITC phalloidin was used to visualize actin in non-neuronal cells (green) under co-culture condition, spiral ganglion neurites appeared thicker in the presence of neurotrophin-producing fibroblasts. NT-3: Neurotrophin-3; BDNF: brain-derived neurotrophic factor.
Credit: Neural Regeneration Research

Cochlear implants, electrical prosthetic devices that stimulate inner ear neurons of individuals who have lost their cochlear sensory cells, restore usable hearing to deaf patients. Cochlear implant electrodes are placed in the fluid-filled scala tympani of the cochlea, at a significant distance from the spiral ganglion and even from the spiral ganglion dendrites.

Related Articles


Stimulation via a cochlear implant electrode pair is therefore likely to activate large numbers of neurons concurrently. This may decrease the resolution and dynamic range of information transmitted in patients with cochlear implants. The low precision of electrical neural activation, compared to the precise activation that occurs in the normal cochlea, may explain why increasing the number of electrodes on a cochlear implant beyond 8–10 does not improve functionality.

However, if cochlear neurons could be induced to extend neurites toward a cochlear implant, it might be possible to stimulate more discrete subpopulations, and to increase the resolution of the device. Prof. Allen F. Ryan and colleagues from University of California exposed spiral ganglion explants from neonatal rats to soluble neurotrophins, cells transfected to secrete neurotrophins, and/or collagen gels.

Researchers found that cochlear neurites grew readily on collagen surfaces and in three-dimensional collagen gels. Co-culture with cells producing neurotrophin-3 resulted in increased numbers of neurites, and neurites that were longer than when explants were cultured with control fibroblasts stably transfected with green fluorescent protein.

It is suggested that extracellular matrix molecule gels and cells transfected to produce neurotrophins offer an opportunity to attract spiral ganglion neurites toward a cochlear implant.


Story Source:

The above story is based on materials provided by Neural Regeneration Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xie J, Pak K, Evans A, Kamgar-Parsi A, Fausti S, Mullen L, Ryan AF. Neurotrophins differentially stimulate the growth of cochlear neurites on collagen surfaces and in gels. Neural Regen Res., 2013;8(17):1541-1550 DOI: 10.3969/j.issn.1673-5374.2013.17.001

Cite This Page:

Neural Regeneration Research. "New technology will improve neuron activation induced by cochlear implants." ScienceDaily. ScienceDaily, 17 July 2013. <www.sciencedaily.com/releases/2013/07/130717095526.htm>.
Neural Regeneration Research. (2013, July 17). New technology will improve neuron activation induced by cochlear implants. ScienceDaily. Retrieved October 30, 2014 from www.sciencedaily.com/releases/2013/07/130717095526.htm
Neural Regeneration Research. "New technology will improve neuron activation induced by cochlear implants." ScienceDaily. www.sciencedaily.com/releases/2013/07/130717095526.htm (accessed October 30, 2014).

Share This



More Health & Medicine News

Thursday, October 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Mind-Controlled Prosthetic Arm Restores Amputee Dexterity

Reuters - Innovations Video Online (Oct. 29, 2014) A Swedish amputee who became the first person to ever receive a brain controlled prosthetic arm is able to manipulate and handle delicate objects with an unprecedented level of dexterity. The device is connected directly to his bone, nerves and muscles, giving him the ability to control it with his thoughts. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Google To Use Nanoparticles, Wearables To Detect Disease

Google To Use Nanoparticles, Wearables To Detect Disease

Newsy (Oct. 29, 2014) Google X wants to improve modern medicine with nanoparticles and a wearable device. It's all an attempt to tackle disease detection and prevention. Video provided by Newsy
Powered by NewsLook.com
Can Drinking Milk Lead To Early Death?

Can Drinking Milk Lead To Early Death?

Newsy (Oct. 29, 2014) Researchers in Sweden released a study showing heavy milk drinkers face an increased mortality risk from a variety of causes. Video provided by Newsy
Powered by NewsLook.com
Obama: The US Will Not 'run and Hide' From Ebola

Obama: The US Will Not 'run and Hide' From Ebola

AP (Oct. 29, 2014) Surrounded by health care workers in the White House East Room, President Barack Obama said the U.S. will likely see additional Ebola cases in the weeks ahead. But he said the nation can't seal itself off in the fight against the disease. (Oct. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins