Featured Research

from universities, journals, and other organizations

Team of proteins could have implications for fight against cancer

Date:
August 7, 2013
Source:
University of Warwick
Summary:
Researchers have identified the key role played by a team of proteins in the process of mitosis. Working out how to control them may give scientists a way to destroycancerous cells.

The mitotic spindle in a human cell: showing TACC 3 in green, clathrin in red and chromosomes in blue.
Credit: Royle

Researchers at Warwick Medical School have identified the key role played by a team of proteins in the process of mitosis. Working out how to control them may give scientists a way to destroy cancerous cells.

The study, published in The Journal of Cell Biology, highlights the role of a newly identified team of proteins, TACC3-ch-TOG-clathrin, in forming inter-microtubule bridges that stabilise the kinetochore fibres (K-fibres) used in mitosis.

When a cell divides, it produces a mitotic spindle which then makes sure that the chromosomes are divided equally between the two new cells. Failure to do so efficiently can lead to problems; those cells with either too few or too many chromosomes are at risk of becoming cancerous.

In order to do this the mitotic spindle uses K-fibres to allow for chromosome movement around the cell. These fibres are composed of even smaller microtubules, bundled together via what may be termed 'bridges' -- which is where the team of proteins comes in.

Clathrin is a protein that is involved in the process of membrane trafficking in interphase cells, but it switches role during mitosis and localises to the mitotic spindle where it works alongside TACC3 and ch-TOG to form these bridges.

When TACC3 is removed from the cell, the clathrin is no longer able to bind the microtubules. Other bridges do exist but they only represent about 40% of the total so the microtubules, and as a result the mitotic spindle, are significantly weaker.

By developing methods to rapidly remove the team of proteins, the researchers have been able to determine that removing TACC3 allows us to make the cells arrest and die.

Professor Royle explained, "That sounds like a negative, the idea of a cell dying. However it's vital to remember that most adult cells are no longer dividing and what we are suggesting is being able to shut down mitosis in those that are multiplying."

There are other functions associated with cell division that would need to be considered, such as repairing damage, but Royle firmly believes that this is still an important step in tackling cancerous cells.

He added, "Though it isn't yet capable of being fully targeted to kill only cancerous cells, neither are the current treatments. Existing drugs like taxanes, for example, do not discriminate between cancerous cells and normal cells. Hopefully the next development will allow us to use a greater understanding of how this team of proteins can be used in a more clinical environment."


Story Source:

The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.


Journal Reference:

  1. F. E. Hood, S. J. Williams, S. G. Burgess, M. W. Richards, D. Roth, A. Straube, M. Pfuhl, R. Bayliss, S. J. Royle. Coordination of adjacent domains mediates TACC3-ch-TOG-clathrin assembly and mitotic spindle binding. The Journal of Cell Biology, 2013; 202 (3): 463 DOI: 10.1083/jcb.201211127

Cite This Page:

University of Warwick. "Team of proteins could have implications for fight against cancer." ScienceDaily. ScienceDaily, 7 August 2013. <www.sciencedaily.com/releases/2013/08/130807094350.htm>.
University of Warwick. (2013, August 7). Team of proteins could have implications for fight against cancer. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2013/08/130807094350.htm
University of Warwick. "Team of proteins could have implications for fight against cancer." ScienceDaily. www.sciencedaily.com/releases/2013/08/130807094350.htm (accessed July 24, 2014).

Share This




More Health & Medicine News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Idaho Boy Helps Brother With Disabilities Complete Triathlon

Newsy (July 23, 2014) An 8-year-old boy helped his younger brother, who has a rare genetic condition that's confined him to a wheelchair, finish a triathlon. Video provided by Newsy
Powered by NewsLook.com
Thousands Who Can't Afford Medical Care Flock to Free US Clinic

Thousands Who Can't Afford Medical Care Flock to Free US Clinic

AFP (July 23, 2014) America may be the world’s richest country, but in terms of healthcare, the World Health Organisation ranks it 37th. Thousands turned out for a free clinic run by "Remote Area Medical" with a visit from the Governor of Virginia. Duration: 2:40 Video provided by AFP
Powered by NewsLook.com
Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins