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Material in dissolvable sutures could treat brain infections, reducing hospital stays

Date:
August 7, 2013
Source:
American Chemical Society
Summary:
A plastic material already used in absorbable surgical sutures and other medical devices shows promise for continuous administration of antibiotics to patients with brain infections. Use of the material, placed directly on the brain's surface, could reduce the need for weeks of costly hospital stays now required for such treatment.

A plastic material already used in absorbable surgical sutures and other medical devices shows promise for continuous administration of antibiotics to patients with brain infections, scientists are reporting in a new study. Use of the material, placed directly on the brain's surface, could reduce the need for weeks of costly hospital stays now required for such treatment, they say in the journal ACS Chemical Neuroscience.

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Shih-Jung Liu and colleagues explain that infections are life-threatening complications that occur in about 5-10 percent of patients who have brain surgery. Current treatment involves intravenous antibiotics for up to eight weeks and extended, costly hospital stays. Previous studies showed that drug-delivering plastics could release antibiotics directly into the brain. However, additional surgery was needed to remove the plastic when treatment finished. Liu's team sought to develop a biodegradable version using a dissolvable plastic called PLGA.

They describe development of PLGA fibers that release vancomycin, a powerful antibiotic that kills many microbes, including the infamous "MRSA," which shrugs off most other known antibiotics. They tested the fibers in rats, which are stand-ins for humans in these types of studies. The fibers successfully released vancomycin for more than eight weeks in the brain and did so without apparent side effects.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yuan-Yun Tseng, Yu-Chun Kao, Jun-Yi Liao, Wei-An Chen, Shih-Jung Liu. Biodegradable Drug-Eluting Poly[lactic-co-glycol acid] Nanofibers for the Sustainable Delivery of Vancomycin to Brain Tissue: In Vitro and in Vivo Studies. ACS Chemical Neuroscience, 2013; 130712092219001 DOI: 10.1021/cn400108q

Cite This Page:

American Chemical Society. "Material in dissolvable sutures could treat brain infections, reducing hospital stays." ScienceDaily. ScienceDaily, 7 August 2013. <www.sciencedaily.com/releases/2013/08/130807134135.htm>.
American Chemical Society. (2013, August 7). Material in dissolvable sutures could treat brain infections, reducing hospital stays. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2013/08/130807134135.htm
American Chemical Society. "Material in dissolvable sutures could treat brain infections, reducing hospital stays." ScienceDaily. www.sciencedaily.com/releases/2013/08/130807134135.htm (accessed November 24, 2014).

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