Featured Research

from universities, journals, and other organizations

Scientists make new discoveries in the transmission of viruses between animals and humans

Date:
August 12, 2013
Source:
DOE/Lawrence Livermore National Laboratory
Summary:
Outbreaks such as the severe acute respiratory syndrome (SARS), and Middle East respiratory syndrome coronavirus (MERS), have afflicted people around the world, yet many people think these trends are on the decline.

Outbreaks such as the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS) have afflicted people around the world, yet many people think these trends are on the decline.

Quite the opposite is true.

The efforts to combat this epidemic are being spearheaded by a team of Lawrence Livermore National Laboratory (LLNL) scientists. Led by Monica Borucki of LLNL's Biosciences and Biotechnology Division, the Lab researchers have made promising new discoveries that provide insight into the emergence of inter-species transmittable viruses.

They discovered that the genetic diversity of a viral population within a host animal could allow a virus to adapt to certain conditions, which could help it reach a human host. This discovery advances the scientific understanding of how new viruses produced from animal reservoirs can infect people. An animal reservoir is an animal species that harbors an infectious agent, which then goes on to potentially infect humans or other species. Borucki's team is investigating viruses related to SARS and MERS, but not the actual viruses themselves.

"The team's findings are the first steps in developing methods for predicting which viral species are most likely to jump from animals to humans and potentially cause outbreaks of diseases," Borucki said.

Borucki's LLNL multidisciplinary research team includes Jonathan Allen, Tom Slezak, Clinton Torres and Adam Zemla from the Computation Directorate; Haiyin Chen from the Engineering Directorate; and Pam Hullinger, Gilda Vanier and Shalini Mabery from the Physical and Life Sciences Directorate.

Coronaviruses are one of the groups of viruses that most commonly jump to new host species as evidenced by SARS and MERS, according to Borucki. These viruses appear to have jumped from animals to humans and are capable of causing severe diseases in humans.

"Our discoveries indicate that the next generation of genetic sequencing technology, combined with advance computational analysis, can be used to characterize the dynamics of certain viral populations," she said.

The team's work on coronaviruses received funding from LLNL's Laboratory Directed Research and Development (LDRD) program and the Defense Threat Reduction Agency (DTRA).

In June, a research paper published in the Journal of General Virology by other scientists cited the Borucki team's findings as pioneering, and it recommended their methodology for studying viral evolution.

Borucki said her team's research findings eventually could be used to influence how vaccines and antivirals are designed and tested.

"Deep Illumina sequencing (a type of genetic sequencing that involves sequencing reads in parallel) is already being used extensively to understand HIV and hepatitis C resistance to antivirals," she said. "We plan to follow up our findings by examining how animal host traits such as nutritional status (being malnourished or obese) influence how viruses evolve."

This latest discovery is part of a string of achievements for Borucki's team.

In 2010, they secured a three-year, $1.4 million contract from DTRA to fund a research project to study how to better determine the origins of a virus.

For more information, see:https://www.llnl.gov/news/newsreleases/2013/Aug/NR-13-08-01.html#.UiuxObzgKMI


Story Source:

The above story is based on materials provided by DOE/Lawrence Livermore National Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

DOE/Lawrence Livermore National Laboratory. "Scientists make new discoveries in the transmission of viruses between animals and humans." ScienceDaily. ScienceDaily, 12 August 2013. <www.sciencedaily.com/releases/2013/08/130812155105.htm>.
DOE/Lawrence Livermore National Laboratory. (2013, August 12). Scientists make new discoveries in the transmission of viruses between animals and humans. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2013/08/130812155105.htm
DOE/Lawrence Livermore National Laboratory. "Scientists make new discoveries in the transmission of viruses between animals and humans." ScienceDaily. www.sciencedaily.com/releases/2013/08/130812155105.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Study Links Male-Pattern Baldness To Prostate Cancer

Study Links Male-Pattern Baldness To Prostate Cancer

Newsy (Sep. 16, 2014) New findings suggest men with a certain type of baldness at age 45 are 39 percent more likely to develop aggressive prostate cancer. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins