Featured Research

from universities, journals, and other organizations

How bacteria found in mouth may cause colorectal cancer

Date:
August 14, 2013
Source:
Cell Press
Summary:
Gut microbes have recently been linked to colorectal cancer, but it has not been clear whether and how they might cause tumors to form in the first place. Two studies reveal how gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors. The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

Gut microbes have recently been linked to colorectal cancer, but it has not been clear whether and how they might cause tumors to form in the first place. Two studies published by Cell Press on August 14th in the journal Cell Host & Microbe reveal how gut microbes known as fusobacteria, which are found in the mouth, stimulate bad immune responses and turn on cancer growth genes to generate colorectal tumors. The findings could lead to more effective strategies for the early diagnosis, prevention, and treatment of colorectal cancer.

"Fusobacteria may provide not only a new way to group or describe colon cancers but also, more importantly, a new perspective on how to target pathways to halt tumor growth and spread," says senior study author Wendy Garrett of the Harvard School of Public Health and the Dana-Farber Cancer Institute.

Colorectal cancer is the second leading cause of cancer-related death in the United States. Recent studies have shown that fusobacteria from the mouth are also abundant in tissues from colorectal cancer patients. But until now, it was not known whether these microbes directly contribute to the formation of tumors.

In one of the new studies, Garrett, Matthew Meyerson of the Dana-Farber Cancer Institute, and their collaborators found that fusobacteria are prevalent in human adenomas -- benign tumors that can become malignant over time -- suggesting that these microbes contribute to early stages of tumor formation. In a mouse model of colorectal cancer, these bacteria accelerated the formation of tumors by attracting immune cells called myeloid cells, which invade tumors and stimulate inflammatory responses that can cause cancer.

In the second study, Yiping Han of Case Western Reserve University School of Dental Medicine and her collaborators discovered that fusobacteria rely on a molecule called Fusobacterium adhesin A (FadA), which is found on the surface of these bacterial cells, to attach to and invade human colorectal cancer cells. FadA then turns on cancer growth genes and stimulates inflammatory responses in these cells and promotes tumor formation.

Han and her team also found that FadA levels were much higher in tissues from patients with adenomas and colorectal cancer compared with healthy individuals. Moreover, they identified a compound that can prevent FadA's effects on cancer cells. "We showed that FadA is a marker that can be used for the early diagnosis of colorectal cancer and identified potential therapeutic targets to treat or prevent this common and debilitating disease," Han says.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal References:

  1. MaraRoxana Rubinstein, Xiaowei Wang, Wendy Liu, Yujun Hao, Guifang Cai, YipingW. Han. Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin. Cell Host & Microbe, 2013; 14 (2): 195 DOI: 10.1016/j.chom.2013.07.012
  2. AleksandarD. Kostic, Eunyoung Chun, Lauren Robertson, JonathanN. Glickman, CareyAnn Gallini, Monia Michaud, ThomasE. Clancy, DanielC. Chung, Paul Lochhead, GeorginaL. Hold, EmadM. El-Omar, Dean Brenner, CharlesS. Fuchs, Matthew Meyerson, WendyS. Garrett. Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment. Cell Host & Microbe, 2013; 14 (2): 207 DOI: 10.1016/j.chom.2013.07.007

Cite This Page:

Cell Press. "How bacteria found in mouth may cause colorectal cancer." ScienceDaily. ScienceDaily, 14 August 2013. <www.sciencedaily.com/releases/2013/08/130814124329.htm>.
Cell Press. (2013, August 14). How bacteria found in mouth may cause colorectal cancer. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2013/08/130814124329.htm
Cell Press. "How bacteria found in mouth may cause colorectal cancer." ScienceDaily. www.sciencedaily.com/releases/2013/08/130814124329.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins