Featured Research

from universities, journals, and other organizations

Major study links aging gene to blood cancer

Date:
August 18, 2013
Source:
Institute of Cancer Research
Summary:
A gene that helps control the ageing process by acting as a cell's internal clock has been linked to cancer by a major new study. Scientists found a genetic variant that influences the ageing process among four new variants they linked to myeloma -- one of the most common types of blood cancer. The study more than doubles the number of genetic variants linked to myeloma.

A gene that helps control the ageing process by acting as a cell's internal clock has been linked to cancer by a major new study.

Related Articles


Scientists at The Institute of Cancer Research, London, found a genetic variant that influences the ageing process among four new variants they linked to myeloma -- one of the most common types of blood cancer.

The study more than doubles the number of genetic variants linked to myeloma, bringing the total number to seven, and sheds important new light on the genetic causes of the disease.

The research, published in the journal Nature Genetics August 18, was mainly funded by charities Leukaemia & Lymphoma Research and Myeloma UK, with additional support from Cancer Research UK.

Myeloma affects around 4,700 patients each year, and is caused by genetic mutations in white blood cells, which normally help fight infection and injury. Less than four in 10 sufferers survive the disease for more than five years, and three in 10 die within a year (1).

One genetic marker found by the researchers is linked to a gene called TERC, which regulates the length of the telomere 'caps' on the ends of DNA. In healthy cells, these caps erode over time -- causing tissues to age -- but some cancer cells seem able to ignore the ageing trigger in order to keep on dividing. If further studies confirm the link, TERC could be a target for future myeloma treatments.

The team found the new markers by comparing the genetic make-up of a total of 4,692 myeloma patients with DNA from 10,990 people without the disease. A previous UK study led by the team, from The Institute of Cancer Research (ICR) and funded by Myeloma UK, found three genetic variants, or 'spelling mistakes' in DNA, which lead to increased risk of developing myeloma.

The team found the new batch of genetic variants by combining their samples with others from researchers in Germany. The combined results gave the scientists more data and therefore greater statistical accuracy.

All of the four new genetic variants are close to genes which are likely to play important roles in causing myeloma.

Study co-leader Professor Richard Houlston, Professor of Molecular and Population Genetics at The Institute of Cancer Research, said:

"Our study has taken an important step forward in understanding the genetics of myeloma, and suggested an intriguing potential link with a gene that acts as a cell's internal timer.

"We know cancer often seems to ignore the usual controls over ageing and cell death, and it will be fascinating to explore whether in blood cancers that is a result of a direct genetic link. Eventually, understanding the complex genetics of blood cancers should allow us to assess a person's risk or identify new avenues for treatment."

In people affected by myeloma, white blood cells called plasma cells grow uncontrollably in the bone marrow and become stuck there, disrupting normal blood production. It can be very painful, and affects bones in multiple parts of the body.

Professor Chris Bunce, Research Director at Leukaemia & Lymphoma Research, said: "The identification of these risk gene variants offers more compelling evidence that susceptibility to myeloma can be inherited. Myeloma remains incurable and the effect on patients' quality of life can be devastating.

"By showing how these specific genes influence the cancer's development, this research could potentially lead to the development of targeted myeloma drugs in the future. In addition we know that a common condition called MGUS predisposes to the development of myeloma. The identification of additional genetic risk factors in these patients could revolutionise their future management and prospects."

Heather McKinnon, Clinical Research Programme Manager for Myeloma UK,, said: "We are delighted the original study funded by Myeloma UK two years ago into genetic inheritance in myeloma has now led to further important research. The study published today in Nature Genetics identifies four more genetic variations in myeloma and for the first time demonstrates an association with ageing. Myeloma UK is committed to supporting this important research and invests in a programme of work at The Institute of Cancer Research."


Story Source:

The above story is based on materials provided by Institute of Cancer Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Daniel Chubb, Niels Weinhold, Peter Broderick, Bowang Chen, David C Johnson, Asta Försti, Jayaram Vijayakrishnan, Gabriele Migliorini, Sara E Dobbins, Amy Holroyd, Dirk Hose, Brian A Walker, Faith E Davies, Walter A Gregory, Graham H Jackson, Julie A Irving, Guy Pratt, Chris Fegan, James A L Fenton, Kai Neben, Per Hoffmann, Markus M Nöthen, Thomas W Mühleisen, Lewin Eisele, Fiona M Ross, Christian Straka, Hermann Einsele, Christian Langer, Elisabeth Dörner, James M Allan, Anna Jauch, Gareth J Morgan, Kari Hemminki, Richard S Houlston, Hartmut Goldschmidt. Common variation at 3q26.2, 6p21.33, 17p11.2 and 22q13.1 influences multiple myeloma risk. Nature Genetics, 2013; DOI: 10.1038/ng.2733

Cite This Page:

Institute of Cancer Research. "Major study links aging gene to blood cancer." ScienceDaily. ScienceDaily, 18 August 2013. <www.sciencedaily.com/releases/2013/08/130818144426.htm>.
Institute of Cancer Research. (2013, August 18). Major study links aging gene to blood cancer. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2013/08/130818144426.htm
Institute of Cancer Research. "Major study links aging gene to blood cancer." ScienceDaily. www.sciencedaily.com/releases/2013/08/130818144426.htm (accessed October 25, 2014).

Share This



More Health & Medicine News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com
WHO: Millions of Ebola Vaccine Doses by 2015

WHO: Millions of Ebola Vaccine Doses by 2015

AP (Oct. 24, 2014) — The World Health Organization said on Friday that millions of doses of two experimental Ebola vaccines could be ready for use in 2015 and five more experimental vaccines would start being tested in March. (Oct. 24) Video provided by AP
Powered by NewsLook.com
Doctor in NYC Quarantined With Ebola

Doctor in NYC Quarantined With Ebola

AP (Oct. 24, 2014) — An emergency room doctor who recently returned to the city after treating Ebola patients in West Africa has tested positive for the virus. He's quarantined in a hospital. (Oct. 24) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins