Featured Research

from universities, journals, and other organizations

How women achieve a healthier weight may impact long-term health of offspring

Date:
August 21, 2013
Source:
University of Cincinnati Academic Health Center
Summary:
New research suggests that the healthy weight and glucose control women achieve through weight-loss surgery don't necessarily translate into health benefits for their future children.

New research from the University of Cincinnati (UC) suggests that the healthy weight and glucose control women achieve through weight-loss surgery don't necessarily translate into health benefits for their future children.

Related Articles


An animal study featured in the Aug. 21, 2013, edition of the journal Science Translational Medicine suggests that treatment with vertical sleeve gastrectomy (VSG) weight loss surgery of a female rat prior to conception has no positive impact on -- and could even impact negatively -- the metabolic health of her offspring.

The study was led by Bernadette Grayson, PhD, postdoctoral fellow in the laboratory of Randy Seeley, PhD, UC professor and Donald C. Harrison Endowed Chair in Medicine and director of the Cincinnati Diabetes and Obesity Center.

"Maternal obesity and diabetes have long-term negative health consequences for offspring in both rodents and humans," says Grayson. "Bariatric surgical procedures like vertical sleeve gastrectomy are still the most effective way to achieve sustained weight loss and improvements in glucose levels."

Knowing this, Grayson, Seeley and team set out to determine if improving maternal obesity by treating with VSG pre-pregnancy could improve the metabolic health of the offspring.

Female rats were given high-fat diets to induce obesity and then some were treated with the VSG procedure. (During VSG, a portion of the stomach is removed to leave a much smaller "sleeve"-like section.) The female rats that underwent VSG lost weight, had improved glucose control and even showed some improvements in reproductive health when compared with obese rats that did not have the same procedure. But metabolic health of the VSG rats' offspring did not improve.

"On some measures the health of these offspring, in fact, got worse," Seeley says. "Their birth weights were lower when compared to rats whose mothers didn't receive the surgery. And when they were given access to a high-fat diet following puberty, offspring of VSG rats showed a greater propensity to gain body fat and develop glucose intolerance."

There are many causes for small-for-gestational age births, Seeley says.

"In the case of VSG, the hormonal changes induced by the surgery, which aid in weight loss, may be the very same culprits for the reduced growth. This is something we will be looking at in future research," he says.

"It may not be sufficient enough just to get mom healthier before she conceives; how she gets healthier seems to matter," says Seeley, adding that the diet the mom consumed during pregnancy in these studies also played a huge role. "The interaction between diet and the maternal environments -- the uterus and placenta, for example -- may impact susceptibility to metabolic disease in offspring."

These findings, the authors say, could have implications for the clinical use of surgical weight loss procedures, but more work is needed before clear guidelines can be determined.

The next steps, say Grayson and Seeley, are to determine the direct cause of the effect on the offspring and find out if other types of surgical weight loss procedures have similar effects.

This work, they say, also has the potential to help in our understanding of how the maternal environment can increase or decrease the risk for obesity and diabetes in future generations.


Story Source:

The above story is based on materials provided by University of Cincinnati Academic Health Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. B. E. Grayson, K. M. Schneider, S. C. Woods, R. J. Seeley. Improved Rodent Maternal Metabolism But Reduced Intrauterine Growth After Vertical Sleeve Gastrectomy. Science Translational Medicine, 2013; 5 (199): 199ra112 DOI: 10.1126/scitranslmed.3006505

Cite This Page:

University of Cincinnati Academic Health Center. "How women achieve a healthier weight may impact long-term health of offspring." ScienceDaily. ScienceDaily, 21 August 2013. <www.sciencedaily.com/releases/2013/08/130821152102.htm>.
University of Cincinnati Academic Health Center. (2013, August 21). How women achieve a healthier weight may impact long-term health of offspring. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2013/08/130821152102.htm
University of Cincinnati Academic Health Center. "How women achieve a healthier weight may impact long-term health of offspring." ScienceDaily. www.sciencedaily.com/releases/2013/08/130821152102.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins