Featured Research

from universities, journals, and other organizations

Pre-pregnancy hormone testing may indicate gestational diabetes risk

Date:
August 29, 2013
Source:
Kaiser Permanente
Summary:
Overweight women with low levels of the hormone adiponectin prior to pregnancy are nearly seven times more likely to develop gestational diabetes. Research now indicates that Adiponectin protects against insulin resistance, inflammation and heart disease.

Overweight women with low levels of the hormone adiponectin prior to pregnancy are nearly seven times more likely to develop gestational diabetes, according to a Kaiser Permanente study published today in the journal Diabetes Care. Adiponectin protects against insulin resistance, inflammation and heart disease.

Using Kaiser Permanente HealthConnectฎ, an electronic health records system, the researchers retrospectively identified about 4,000 women who gave voluntary blood samples between 1985 and 1996 during routine care and subsequently delivered an infant. Among that group, 256 women developed gestational diabetes during pregnancy and 497 did not. Researchers found that normal-weight women with low levels of adiponectin were 3.5 times more likely to develop gestational diabetes than their normal-weight peers with normal levels of the hormone. Additionally, overweight women with high levels of adiponectin were 1.7 times as likely to develop gestational diabetes during pregnancy, while those with the lowest levels were 6.8 times more likely.

"Our findings indicate important pregnancy interventions may be possible before a woman even conceives," said Monique M. Hedderson, PhD, principal investigator of the study and research scientist with the Kaiser Permanente Division of Research in Oakland, Calif. "Adiponectin levels are easy and inexpensive to measure and could potentially be used to identify women who are at risk for gestational diabetes."

The relationship between low adiponectin levels prior to pregnancy and the risk of diabetes was highly significant among the study group, according to the researchers, and it increased among women with higher body mass indexes, even after the data was adjusted for confounding factors such as family history of diabetes, race, smoking and blood glucose and insulin levels. This study included women who volunteered to participate in Kaiser Permanente's multiphasic health check-up exam, therefore the population may be more health conscious than the general population. However, the study cohort was very diverse in terms of race-ethnicity and education level. The researchers noted that they expect the observed associations between adiponectin and gestational diabetes would be applicable to the general population.

Gestational diabetes, or glucose intolerance during pregnancy, is common and can lead to adverse outcomes including larger-than-normal babies and subsequent delivery complications. Women with gestational diabetes are seven times more likely to develop type 2 diabetes later in life, and their children are at greater risk of becoming obese and developing diabetes themselves.

"Low adiponectin levels were linked with gestational diabetes even for women without traditional diabetes risk factors such as being overweight, so this could be an important clinical marker for women who may become pregnant. Adiponectin testing early in pregnancy may also help identify high-risk women who would benefit from early diagnosis and treatment of gestational diabetes," Hedderson said. "Future research is needed to determine whether lifestyle interventions targeting diet and physical activity can increase adiponectin levels."


Story Source:

The above story is based on materials provided by Kaiser Permanente. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. M. Hedderson, J. Darbinian, P. J. Havel, C. P. Quesenberry, S. Sridhar, S. Ehrlich, A. Ferrara. Low Prepregnancy Adiponectin Concentrations Are Associated With a Marked Increase in Risk for Development of Gestational Diabetes Mellitus. Diabetes Care, 2013; DOI: 10.2337/dc13-0389

Cite This Page:

Kaiser Permanente. "Pre-pregnancy hormone testing may indicate gestational diabetes risk." ScienceDaily. ScienceDaily, 29 August 2013. <www.sciencedaily.com/releases/2013/08/130829110158.htm>.
Kaiser Permanente. (2013, August 29). Pre-pregnancy hormone testing may indicate gestational diabetes risk. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2013/08/130829110158.htm
Kaiser Permanente. "Pre-pregnancy hormone testing may indicate gestational diabetes risk." ScienceDaily. www.sciencedaily.com/releases/2013/08/130829110158.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Microneedle Patch Promises Painless Pricks

Microneedle Patch Promises Painless Pricks

Reuters - Innovations Video Online (Oct. 18, 2014) — Researchers at The National University of Singapore have invented a new microneedle patch that could offer a faster and less painful delivery of drugs such as insulin and painkillers. Video provided by Reuters
Powered by NewsLook.com
Raw: Nurse Nina Pham Arrives in Maryland

Raw: Nurse Nina Pham Arrives in Maryland

AP (Oct. 17, 2014) — The first nurse to be diagnosed with Ebola at a Dallas hospital walked down the stairs of an executive jet into an ambulance at an airport in Frederick, Maryland, on Thursday. Pham will be treated at the National Institutes of Health. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Raw: Cruise Ship Returns to US Over Ebola Fears

Raw: Cruise Ship Returns to US Over Ebola Fears

AP (Oct. 17, 2014) — A Caribbean cruise ship carrying a Dallas health care worker who is being monitored for signs of the Ebola virus is heading back to Texas, US, after being refused permission to dock in Cozumel, Mexico. (Oct. 17) Video provided by AP
Powered by NewsLook.com
Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

Spanish Govt: Four Suspected Ebola Cases in Spain Test Negative

AFP (Oct. 17, 2014) — All four suspected Ebola cases admitted to hospitals in Spain on Thursday have tested negative for the deadly virus in a first round of tests, the government said Friday. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins