Featured Research

from universities, journals, and other organizations

Cell study offers more diabetic patients chance of transplant

Date:
August 29, 2013
Source:
University of Edinburgh
Summary:
Diabetic patients could benefit from a breakthrough that enables scientists to take cells from the pancreas and change their function to produce insulin. The research could reduce waiting times for patients with type 1 Diabetes who need islet cell transplants. These transplants are carried out to prevent life-threatening complications resulting from diabetes, such as seizures resulting from low blood sugar levels.

Diabetic patients could benefit from a breakthrough that enables scientists to take cells from the pancreas and change their function to produce insulin.

Related Articles


The research could reduce waiting times for patients with Type 1 Diabetes who need islet cell transplants. These transplants are carried out to prevent life-threatening complications resulting from diabetes, such as seizures resulting from low blood sugar levels.

Islet cells -- which occur naturally in the pancreas -- produce insulin, which enables the body to store glucose. However, not enough of these cells can be provided by a single donor for a successful islet transplant to take place.

This means that patients can wait months before a second pancreas becomes available so that a sufficient number of islet cells to be transplanted.

The breakthrough, published in the journal Diabetes, could enable pancreatic cells -- other than islets -- to be developed in the laboratory for transplant operations.

It was carried out by the University of Aberdeen, the Medical Research Council Centre for Regenerative Medicine at the University of Edinburgh and the Scottish National Blood Transfusion Service.

Only one pancreas donation would be needed to enable the successful transplantation of insulin-producing cells, which would save months waiting for a second donor to become available as well as make more organs available for other patients.

This would involve an islet cell transplant once an organ becomes available, followed by a second transplant soon after when enough pancreatic cells have been developed to produce insulin.

The effects of the operations would also be longer lasting than currently as more cells would be transplanted.

Islet cell transplants are given to Type 1 diabetics -- who are unable to make insulin and are dependent on insulin injections -- to treat severe hypoglycemic unawareness.

This condition can cause potentially fatal seizures as patients have no warning signals that their blood sugar has reached dangerously low levels.

Almost 20 per cent of patients with Type 1 diabetes suffer from hypoglycemic unawareness.

John Casey, of the University of Edinburgh and also lead clinician for the National Islet Transplant Programme in Scotland, said: "There is a shortage of organ donors, which is not helped by the need for two pancreases to be donated to treat each patient. Developing previously unusable cells to produce insulin means that fewer donors would be needed, which would make a huge difference to patients waiting for transplants operations."

The research was funded by the Medical Research Council.

Professor Kevin Docherty, of the University of Aberdeen, said: "This is an example of how reprogramming, -- the ability to change one cell type into another -- can have a huge impact on the development of cell based therapy for diabetes and many other diseases."

An islet cell transplant programme was introduced in the UK in 2008. Since then, over 90 islet transplants have been successfully carried out in the UK with some patients now completely free of insulin injections.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. J. Lima, K. R. Muir, H. M. Docherty, R. Drummond, N. W. A. McGowan, S. Forbes, Y. Heremans, I. Houbracken, J. A. Ross, S. J. Forbes, P. Ravassard, H. Heimberg, J. Casey, K. Docherty. Suppression of Epithelial-to-Mesenchymal Transitioning Enhances Ex Vivo Reprogramming of Human Exocrine Pancreatic Tissue Toward Functional Insulin-Producing  -Like Cells. Diabetes, 2013; 62 (8): 2821 DOI: 10.2337/db12-1256

Cite This Page:

University of Edinburgh. "Cell study offers more diabetic patients chance of transplant." ScienceDaily. ScienceDaily, 29 August 2013. <www.sciencedaily.com/releases/2013/08/130829110200.htm>.
University of Edinburgh. (2013, August 29). Cell study offers more diabetic patients chance of transplant. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2013/08/130829110200.htm
University of Edinburgh. "Cell study offers more diabetic patients chance of transplant." ScienceDaily. www.sciencedaily.com/releases/2013/08/130829110200.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins