Featured Research

from universities, journals, and other organizations

New 'artificial nose' device can speed diagnosis of sepsis

Date:
September 9, 2013
Source:
American Chemical Society (ACS)
Summary:
Disease-causing bacteria stink — literally — and the odor released by some of the nastiest microbes has become the basis for a faster and simpler new way to diagnose serious blood infections and finger the specific microbe, scientists have reported.

Color changes in a simple new “artificial nose” device can detect and identify blood-borne infections faster than current tests.
Credit: James Carey

Disease-causing bacteria stink -- literally -- and the odor released by some of the nastiest microbes has become the basis for a faster and simpler new way to diagnose blood infections and finger the specific microbe, scientists reported in Indianapolis today at the 246th National Meeting & Exposition of the American Chemical Society (ACS).

The new test produces results in 24 hours, compared to as much as 72 hours required with the test hospitals now use, and is suitable for use in developing countries and other areas that lack expensive equipment in hospital labs.

"We have a solution to a major problem with the blood cultures that hospitals have used for more than 25 years to diagnose patients with blood-borne bacterial infections," said James Carey, Ph.D., who presented the report. "The current technology involves incubating blood samples in containers for 24-48 hours just to see if bacteria are present. It takes another step and 24 hours or more to identify the kind of bacteria in order to select the right antibiotic to treat the patient. By then, the patient may be experiencing organ damage, or may be dead from sepsis."

Sepsis, or blood poisoning, is a toxic response to blood-borne infections that kills more than 250,000 people each year in the United States alone. The domestic health-care costs to treat sepsis exceed $20 billion. In such a medical emergency, every minute counts, Carey explained, and giving patients the right antibiotics and other treatment can save lives.

That's why a research team at the University of Illinois that included chemistry professor Ken Suslick, and Carey, set out to develop a faster, simpler test. Carey, of the National University of Kaohsiung in Taiwan in the Republic of China, described a completely new way to identify bacteria compared to an earlier version of such a test developed at Illinois.

The new device consists of a plastic bottle, small enough to fit in the palm of a hand, filled with nutrient solution for bacteria to grow. Attached to the inside is a chemical sensing array (CSA), an "artificial nose," with 36 pigment dots. The dots change color in response to signature odor chemicals released by bacteria.

Using the device is simple, Carey said. A blood sample from a patient is injected into the bottle, which goes onto a simple shaker device to agitate the nutrient solution and encourage bacterial growth. Any bacteria present in the blood sample will grow and release a signature odor that changes the colors of pigment dots on the sensor. The test is complete within a day, and the results can be read in a pattern of color changes unique to each strain of bacteria.

The earlier device could detect odors given off by bacteria only after the bacteria were first grown in laboratory culture dishes. That device used a solid nutrient culture material, which takes longer to grow bacteria than the liquid in the improved test. It also was less sensitive and worked only when larger numbers of bacteria were previously cultivated.

Carey said the new device can identify eight of the most common disease-causing bacteria with almost 99 percent accuracy under clinically relevant conditions. Other microbes can cause sepsis, and the scientists are working to expand the test's capabilities. But Carey said the device could make an impact now in reducing the toll of sepsis, especially in developing countries or other medically underserved areas.

"Our CSA blood culture bottle can be used almost anywhere in the world for a very low cost and minimal training," Carey noted. "All you need is someone to draw a blood sample, an ordinary shaker, incubator, a desktop scanner and a computer."

Carey's research was funded by ChemSensing, Inc., Oklahoma City University, the National Kaohsiung University and the National Science Council of Taiwan. It builds upon Suslick's research funding from the Genes, Environment and Health Initiative of the National Institutes of Health.


Story Source:

The above story is based on materials provided by American Chemical Society (ACS). Note: Materials may be edited for content and length.


Cite This Page:

American Chemical Society (ACS). "New 'artificial nose' device can speed diagnosis of sepsis." ScienceDaily. ScienceDaily, 9 September 2013. <www.sciencedaily.com/releases/2013/09/130909092338.htm>.
American Chemical Society (ACS). (2013, September 9). New 'artificial nose' device can speed diagnosis of sepsis. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2013/09/130909092338.htm
American Chemical Society (ACS). "New 'artificial nose' device can speed diagnosis of sepsis." ScienceDaily. www.sciencedaily.com/releases/2013/09/130909092338.htm (accessed July 30, 2014).

Share This




More Plants & Animals News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Otters Enjoy Water Slides at Japan Zoo

Raw: Otters Enjoy Water Slides at Japan Zoo

AP (July 30, 2014) River otters were hitting the water slides to beat the summer heatwave on Wednesday at Ichikawa City's Zoological and Botanical Garden. (July 30) Video provided by AP
Powered by NewsLook.com
In Virginia, the Rise of a New Space Coast

In Virginia, the Rise of a New Space Coast

AP (July 30, 2014) Every summer, tourists make the pilgrimage to Chincoteague Island, Va. to see wild ponies cross the Assateague Channel. But, it's the rockets sending to supplies to the International Space Station that are making this a year-round destination. (July 30) Video provided by AP
Powered by NewsLook.com
Rodents Rampant in Gardens Around Louvre

Rodents Rampant in Gardens Around Louvre

AP (July 29, 2014) Food scraps and other items left on the grounds by picnickers brings unwelcome visitors to the grounds of the world famous and popular Louvre Museum in Paris. (July 29) Video provided by AP
Powered by NewsLook.com
Jane Goodall Warns Great Apes Face Extinction

Jane Goodall Warns Great Apes Face Extinction

AFP (July 29, 2014) The world's great apes face extinction within decades, renowned chimpanzee expert Jane Goodall warned Tuesday in a call to arms to ensure man's closest relatives are not wiped out. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins