Featured Research

from universities, journals, and other organizations

DNA repair could lead to improved cancer treatments

Date:
September 10, 2013
Source:
University of Alberta Faculty of Medicine & Dentistry
Summary:
Medical researchers made a basic science discovery that advances the understanding of how DNA repairs itself. When DNA becomes too damaged it ultimately leads to cancer.

Medical researchers at the University of Alberta have made a basic science discovery that advances the understanding of how DNA repairs itself. When DNA becomes too damaged it ultimately leads to cancer.

Faculty of Medicine & Dentistry researcher Mark Glover and his colleagues published their findings in the peer-reviewed journal, Structure (Cell Press), earlier this summer. For years, scientists thought two key proteins involved in DNA repair operated in exactly the same way. Glover's team discovered how the proteins operate and communicate is vastly different -- information that could lead to improved cancer treatments.

Glover explains that a protein known as BRCA1 acts like a hallway monitor -- constantly scanning DNA for damage. At the first sign of problems, this protein figures out what kind of help is needed, and "radios" in a cleanup crew of other proteins.

A second protein, known as TopBP1, ensures that DNA can copy itself when needed. When this process stalls due to DNA damage, this protein also calls in a cleanup crew. But Glover likens its method of communication to tweets, rather than radio.

"The two proteins may be related and look very similar, but their roles and the way they communicate are in fact very different, which was surprising to us," Glover says. "Each protein plays a role in recognizing damaged regions of DNA, but the problem they each solve is different.

"The question now is how can we use this information to try to improve cancer therapies? Could we temporarily knock out cancer DNA's ability to repair itself from radiation damage? Could we administer radiation at a point that prevents cancer DNA from copying itself? Could we inhibit the activity of proteins that are normally trying to run around and fix the damage?

"Maybe some of these ideas could ultimately translate into less radiation or chemotherapy needed for patients, if the treatment can be more targeted," says Glover, who works in the Department of Biochemistry.

His team is continuing its research in this area, and wants to learn more about the role of the TopBP1 protein and why it favours communicating with a specific protein. They also want to conduct tests in their lab to see if the use of certain medications could alter the way these proteins work in a way that could result in new or improved cancer treatments.

Glover's lab members make 3-D images of proteins, making it easier to understand and see how proteins work.


Story Source:

The above story is based on materials provided by University of Alberta Faculty of Medicine & Dentistry. The original article was written by Raquel Maurier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Charles Chung Yun Leung, Luxin Sun, Zihua Gong, Michael Burkat, Ross Edwards, Mark Assmus, Junjie Chen, J.N. Mark Glover. Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control. Structure, 2013; 21 (8): 1450 DOI: 10.1016/j.str.2013.06.015

Cite This Page:

University of Alberta Faculty of Medicine & Dentistry. "DNA repair could lead to improved cancer treatments." ScienceDaily. ScienceDaily, 10 September 2013. <www.sciencedaily.com/releases/2013/09/130910171442.htm>.
University of Alberta Faculty of Medicine & Dentistry. (2013, September 10). DNA repair could lead to improved cancer treatments. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2013/09/130910171442.htm
University of Alberta Faculty of Medicine & Dentistry. "DNA repair could lead to improved cancer treatments." ScienceDaily. www.sciencedaily.com/releases/2013/09/130910171442.htm (accessed August 21, 2014).

Share This




More Health & Medicine News

Thursday, August 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Possible Ebola Patient in Isolation at California Hospital

Possible Ebola Patient in Isolation at California Hospital

Reuters - US Online Video (Aug. 20, 2014) — A patient who may have been exposed to the Ebola virus is in isolation at the Kaiser Permanente South Sacramento Medical Center. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Raw: World's Oldest Man Lives in Japan

Raw: World's Oldest Man Lives in Japan

AP (Aug. 20, 2014) — A 111-year-old Japanese was certified as the world's oldest man by Guinness World Records on Wednesday. Sakari Momoi, a native of Fukushima in northern Japan, was given a certificate at a hospital in Tokyo. (Aug. 20) Video provided by AP
Powered by NewsLook.com
Do More Wedding Guests Make A Happier Marriage?

Do More Wedding Guests Make A Happier Marriage?

Newsy (Aug. 20, 2014) — A new study found couples who had at least 150 guests at their weddings were more likely to report being happy in their marriages. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Freetown a City on Edge

Ebola-Hit Sierra Leone's Freetown a City on Edge

AFP (Aug. 19, 2014) — Residents of Sierra Leone's capital voice their fears as the Ebola virus sweeps through west Africa. Duration: 00:56 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins