Featured Research

from universities, journals, and other organizations

Thyroid hormone key part in the vascular regulation of body temperature

Date:
September 16, 2013
Source:
Karolinska Institutet
Summary:
Researchers have discovered a reason why people with disorders of the thyroid gland may be more sensitive to environmental temperature. According to the study, a previously unknown link has been found between the effects of thyroid hormone on blood vessels, and how this in turn affects body temperature.

Infrared image of a mouse
Credit: Karolinska Institutet

Researchers at Karolinska Institutet have discovered a reason why people with disorders of the thyroid gland may be more sensitive to environmental temperature. According to the study, published in the Proceedings of the National Academy of Sciences (PNAS), a previously unknown link has been found between the effects of thyroid hormone on blood vessels, and how this in turn affects body temperature.

Related Articles


Patients with hyperthyroidism (an overactive thyroid) or hypothyroidism (an underactive thyroid) often feel that they are too hot or too cold, respectively. The cause of this phenomenon has so far been attributed to the thyroid hormones' general effect on the metabolism in the cells themselves.

The thyroid produces hormones that can influence how much the blood vessels dilate and therefore how much heat can escape.

"Our study shows that the temperature sensitivity experienced by thyroid disorder patients might be due to vascular effects, and this knowledge may help future treatment of these patients who are particularly affected," says Dr Amy Warner, researcher at the Department of Cell and Molecular Biology, and the paper's first author.

The researchers studied mice with a defective type of thyroid hormone receptor, meaning that they are hypothyroid in certain tissues, including in the smooth muscle of blood vessels. It was known from previous studies that these mice have an overactive metabolism, caused by the energy needed to generate heat from brown fat, which might seem contradictory given their impaired thyroid hormone function. When the team behind the study took infrared images of the animals, they noticed that they were losing a considerable amount of heat through their tails. Their conclusion was that mice with defective thyroid hormone receptors are unable to properly regulate the constriction of their blood vessels.

"At room temperature, the mice in our study were unable to properly control the blood flow to their tails, which caused heat loss," says Dr Jens Mittag, senior author on the paper. "They therefore needed a backup plan to keep themselves warm and so they produced heat through their brown fat. This tells us that people with a thyroid disorder also might be feeling the cold, but unlike mice, they can partially compensate with extra clothing or turning up the thermostat at home."

The thyroid gland, located in the throat, is subject to a wide range of functional disorders. The findings of this study can add to what is already known about the temperature oversensitivity experienced by patients with thyroid disorders. In the long run, the discovery might possibly lead to treatments that correct dysfunctional vascular regulation.


Story Source:

The above story is based on materials provided by Karolinska Institutet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Amy Warner, Awahan Rahman, Peter Solsj๖, Kristina Gottschling, Benjamin Davis, Bj๖rn Vennstr๖m, Anders Arner, and Jens Mittag. Inappropriate heat dissipation ignites brown fat thermogenesis in mice with a mutant thyroid hormone receptor {alpha}1. PNAS, September 2013 DOI: 10.1073/pnas.1310300110

Cite This Page:

Karolinska Institutet. "Thyroid hormone key part in the vascular regulation of body temperature." ScienceDaily. ScienceDaily, 16 September 2013. <www.sciencedaily.com/releases/2013/09/130916161735.htm>.
Karolinska Institutet. (2013, September 16). Thyroid hormone key part in the vascular regulation of body temperature. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2013/09/130916161735.htm
Karolinska Institutet. "Thyroid hormone key part in the vascular regulation of body temperature." ScienceDaily. www.sciencedaily.com/releases/2013/09/130916161735.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) — As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) — A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) — Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins