Featured Research

from universities, journals, and other organizations

Chronic inflammation of blood vessels connected to childhood mortality in malaria regions

Date:
September 18, 2013
Source:
Wellcome Trust
Summary:
Recurrent episodes of malaria cause chronic inflammation in blood vessels that might predispose to future infections and may increase susceptibility to cardiovascular disease, a study in Malawian children finds.

Small blood vessel in alveoli.
Credit: David Gregory and Debbie Marshall, Wellcome Images.

Recurrent episodes of malaria cause chronic inflammation in blood vessels that might predispose people to future infections and may increase susceptibility to cardiovascular disease, a Wellcome Trust study in Malawian children has found.

The findings could explain the indirect burden of malaria on childhood deaths in areas where the disease is highly prevalent and children experience multiple clinical episodes of malaria in a year.

Malaria is caused when people become infected with a parasite that starts by infecting the liver and then moves into the red blood cells. The most deadly of the malaria parasites is Plasmodium falciparum because of its ability to cause inflammation in blood vessel walls, making them more sticky so that the infected red blood cells can cling to the sides.

Being able to stick to the blood vessels in vital organs allows the parasite to hide away from the immune system, a process called sequestration. When it occurs in the brain it causes a more severe form of the disease called cerebral malaria, which is associated with seizures, coma and sometimes death.

It was thought that the changes in the blood vessel walls that enable the infected red blood cells to stick would resolve quickly once the cells had been cleared; however, the new findings show that inflammation is still present up to one month later.

Researchers from the Malawi-Liverpool-Wellcome Clinical Research Programme at the University of Malawi College of Medicine in Blantyre, Malawi, looked at 190 children with uncomplicated, mild or cerebral malaria and healthy children of the same age. They found that the changes were most pronounced in children with cerebral malaria: the levels of one inflammatory molecule remained 22 times higher than in healthy controls one month after the initial infection.

Dr Chris Moxon, a Wellcome Trust Clinical PhD Fellow and first author of the study, explains: "These findings suggest that children who live in areas of high malaria transmission have persistently inflamed blood vessels, and that could have significant effects on their long-term health.

"It could leave them more susceptible to repeated and more severe infections with malaria, but also with other bacteria and viruses, and chronic changes to the blood vessels like these could be an important contributing factor to cardiovascular disease later in life."

Professor Rob Heyderman, lead author and director of MLW, added: "If follow-up studies in other populations confirm these findings, we should consider whether existing anti-inflammatory drugs such as statins may be able to limit these effects. Short courses of statins could be targeted to children with severe and recurrent disease to try and limit the severity of future infections, but this would need to be evaluated in well-conducted clinical trials."

Around 300 million clinical episodes of malaria are caused by infection with the parasite P. falciparum each year. The disease is transmitted by mosquitoes, and children living in areas where the parasite is particularly prevalent may receive more than one infective bite per day, resulting in repeated clinical episodes of malaria over the course of the year.

Studies have shown that reducing malaria transmission in a population such as this can reduce the number of childhood deaths from any cause by up to 70 per cent, an effect that is much greater than can be explained by reducing malaria alone. The findings from this new study, published today in the Journal of Infectious Diseases, could offer some explanation for the unexplained mortality in areas where malaria transmission is high.


Story Source:

The above story is based on materials provided by Wellcome Trust. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher A. Moxon, Ngawina V. Chisala, Samuel C. Wassmer, Terrie E. Taylor, Karl B. Seydel, Malcolm E. Molyneux, Brian Faragher, Neil Kennedy, Cheng-Hock Toh, Alister G. Craig, and Robert S. Heyderman. Persistent Endothelial Activation and Inflammation After Plasmodium falciparum Infection in Malawian Children. Journal of Infectious Diseases, September 2013 DOI: 10.1093/infdis/jit419

Cite This Page:

Wellcome Trust. "Chronic inflammation of blood vessels connected to childhood mortality in malaria regions." ScienceDaily. ScienceDaily, 18 September 2013. <www.sciencedaily.com/releases/2013/09/130918101950.htm>.
Wellcome Trust. (2013, September 18). Chronic inflammation of blood vessels connected to childhood mortality in malaria regions. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2013/09/130918101950.htm
Wellcome Trust. "Chronic inflammation of blood vessels connected to childhood mortality in malaria regions." ScienceDaily. www.sciencedaily.com/releases/2013/09/130918101950.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins