Featured Research

from universities, journals, and other organizations

Landmark study provides key to improved survival in peritoneal dialysis patients

Date:
September 23, 2013
Source:
Keele University
Summary:

Clinicians and scientists from Keele and Cardiff universities have published data from a landmark study that explains why survival in patients on peritoneal dialysis is low. The paper, entitled ‘Independent Effects of Systemic and Peritoneal Inflammation on Peritoneal Dialysis Survival" is published today in the Journal of the American Society of Nephrology.

Related Articles


Peritoneal dialysis (PD) is a treatment for over 250,000 patients with chronic kidney disease worldwide, using the patient's peritoneum in the abdomen. Currently, only one in ten PD patients survives beyond 10 years on dialysis. For each one-year increase in the patient's age, the risk of death increases by 4% and patients with diabetes have a 30% increased risk of death.

Scientists have now discovered that inflammation in the body and in the peritoneal cavity (where dialysis is performed) are a separate process, which has implications for both the ability to perform dialysis and patient survival. In effect, systemic (whole body) inflammation controls the outcome (survival) whilst peritoneal inflammation controls membrane survival.

Professor Nicholas Topley from Cardiff University and Professor Simon Davies from Keele University designed the study that has taken 12 years to complete:

"Improving survival and doing better dialysis to improve quality of life is the key goal of our research," said Professor Topley from Cardiff University's School of Medicine. "This study was a hard one to bring home because of its length of follow up and the logistics of collecting patient samples worldwide. The importance of the results is self-evident -- this is a big leap forward for PD."

Professor Simon Davies, lead investigator from Keele University, said: "We will now be able to target inflammation to improve survival and recovery. Of course there is more to be done but this will form the basis of understanding that to holistically treat the patient one needs to define the clinical problem."

The 12-year international study, with 10 centres in the UK, Korea and Canada, is the longest and largest of its kind. Researchers recruited more than 1500 patients to the study over a 10-year period and then performed a detailed clinical and immunological analysis of samples obtained from PD patients. This for the first time characterised inflammation in these patients and linked it directly to patient outcomes.

The data will enable clinicians who treat PD patients to be able to target treatment where it is needed, thereby improving and extending the therapy, quality of life and reducing treatment failure.

Dialysis treatment is a daily reality for patients with kidney failure which can last for many years and incurs a huge annual cost for the NHS. A UK estimate suggests that renal disease costs the NHS in England 1.45 billion and 800million in Wales, annually.

More than 250,000 patients worldwide use peritoneal dialysis as their primary form of renal replacement therapy.


Story Source:

The above story is based on materials provided by Keele University. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Lambie, J. Chess, K. L. Donovan, Y. L. Kim, J. Y. Do, H. B. Lee, H. Noh, P. F. Williams, A. J. Williams, S. Davison, M. Dorval, A. Summers, J. D. Williams, J. Bankart, S. J. Davies, N. Topley. Independent Effects of Systemic and Peritoneal Inflammation on Peritoneal Dialysis Survival. Journal of the American Society of Nephrology, 2013; DOI: 10.1681/ASN.2013030314

Cite This Page:

Keele University. "Landmark study provides key to improved survival in peritoneal dialysis patients." ScienceDaily. ScienceDaily, 23 September 2013. <www.sciencedaily.com/releases/2013/09/130923092607.htm>.
Keele University. (2013, September 23). Landmark study provides key to improved survival in peritoneal dialysis patients. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2013/09/130923092607.htm
Keele University. "Landmark study provides key to improved survival in peritoneal dialysis patients." ScienceDaily. www.sciencedaily.com/releases/2013/09/130923092607.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Adults Only Get The Flu Twice A Decade, Researchers Say

Adults Only Get The Flu Twice A Decade, Researchers Say

Newsy (Mar. 4, 2015) Researchers found adults only get the flu about once every five years. Scientists analyzed how a person&apos;s immunity builds up over time as well. Video provided by Newsy
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com
Mount Everest Has a Poop Problem

Mount Everest Has a Poop Problem

Buzz60 (Mar. 4, 2015) With no bathrooms to use, climbers of Mount Everest have been leaving human waste on the mountain for years, and it&apos;s becoming a health issue. Mike Janela (@mikejanela) has more. Video provided by Buzz60
Powered by NewsLook.com
The Best Tips to 'Skinny' Your Home

The Best Tips to 'Skinny' Your Home

Buzz60 (Mar. 4, 2015) If you&apos;re looking to reach your health goals this season, there are a few simple tips to help you spring clean your space and improve your nutrition. Krystin Goodwin (@krystingoodwin) has the skinny on keeping a healthy home. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins